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prevention. Hypertension. 2009;54:3-10. 9. Cameron JD, McGrath BP, Dart AM. Use of radial artery applanation tonometry and a generalized transfer function to determine aortic pressure augmentation in subjects with treated hypertension. JACC. 1998;32 (5):1214-20. 10. Chen CH, Nevo E, Fetics B, Pak PH, Yin FC, Maughan WL, et al. Estimation of central aortic pressure waveform by mathematical transformation of radial tonometry pressure. Validation of generalized transfer function. Circulation. 1997;95:1827-36. 11. London GM, Pannier B. Arterial functions: how to interpret the

blood pressure measurement and pulse wave analysis - their role in enhancing cardiovascular assessment," Physiological Measurement, 31, R1-R47, 2010. [9] Millasseau S.C., Patel S.J., Redwood S.R., Ritter J.M., Chowienczyk P.J., "Pressure wave reflection assessed from the peripheral pulse: is a transfer function necessary," Hypertension, 41, pp. 1016-1020, 2003. [10] da Fonseca L.J.S., Mota-Gomes M.A., Rabelo L.A., "Radial applanation tonometry as an adjuvant tool in the noninvasive arterial sti_ness and blood pressure assessment," World Journal of Cardiovascular

Abstract

Introduction. Cardiovascular events represent an important cause of morbidity and mortality in the entire population. Arterial stiffness is currently considered one of the most important risk factors for the development of cardiovascular events. The gold-standard for evaluating arterial stiffness is pulse wave velocity (PWV). Recent studies have demonstrated that PWV is an independent risk factor regarding the development of cardiovascular events, especially in certain categories of patients.

Material and Methods. The development of cardiovascular events was assessed in 174 patients admitted in the Center of Internal Medicine, Fundeni Clinical Institute, between January 2011 – May 2012. Arterial stiffness was evaluated by measuring PWV using the Sphygmocor system (AtCor, Australia), which is based on the principle of applanation tonometry. The patients were monitored for the development of cardiovascular events (ischemic heart disease, heart failure, stroke, acute myocardial infarction) and for death of cardiovascular cause, over a median period of 51.5 months (43-60 months).

Results. Of the 174 patients, 81 (46.6%) were women and 93 (53.4%) were men. Mean age was 55.96 years. 93 of the 174 patients had chronic kidney failure in different stages (47.3% in stage V). Regarding PWV in the patient group, we obtained a mean score of 9.382. We observed a significant difference regarding the PWV level only for acute myocardial infarction and death between patients who developed these events and those who did not.

Conclusions. Our study demonstrates that PWV increase can be positively associated with the occurrence of cardiovascular events, particularly in certain groups of patients

. “The influence of central corneal thickness and age on intraocular pressure measured by pneumotonometry, noncontact tonometry, the Tono-Pen XL, and Goldmann applanation tonometry”, Br. J. Ophthalmology 89, pp. 851 – 854, 2005 . [4] Garcia-Porta, N., Fernandes, P., Queiros, A., Salgado-Borges, J., Parafita-Mato, M., González-Méijome, J. M. “Corneal Biomechanical Properties in Different Ocular Conditions and New Measurement Techniques”, ISRN Ophthalmology, Article ID 724546, 19 pages, 2014 . DOI: 10.1155/2014/724546 [5] Liu, J., He, X. “Corneal Stiffness Affects IOP

, Zidek W, Tepel M, Scholze A. Noninvasive cardiac output determination using applanation tonometry-derived radial artery pulse contour analysis in critically ill patients. Anesth Analg. 2008; 106:171-4. 10.1213/01.ane.0000297440.52059.2c 37. Lind L, Pettersson K, Johansson K. Analysis of endothelium-dependent vasodilation by use of the radial artery pulse wave obtained by applanation tonometry. Clin Physiol Funct Imaging. 2003; 23:50-7. 10.1046/j.1475-097X.2003.00469.x 38. Jiang D, Huang J, Zhang Y. The cross-validated AUC for MCP-logistic regression with high

to benefits and disadvantages. Even though it is the oldest, the Schiotz tonometer still remains in use with animals. Nowadays it is very rarely used in humans, having been replaced be applanation tonometry and non-contact methods like air-puff tonometry. It can be still used in particular cases like post keratoplasty patients ( 3 ). According to our findings, it is also used in veterinary medicine in many centres dealing with small animal ophthalmology; however, recent studies on its use and results obtained with it are lacking. In the study, the mean results for