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Analysis in silico of the single nucleotide polymorphism G–152A in the promoter of the angiotensinogen gene of Indonesian patients with essential hypertension

transcriptional activity of the gene. The promoter is the center for regulation of gene transcription because it contains numerous transcription factor-binding sites [ 4 ]. Several SNPs in the promoter of the angiotensinogen gene ( AGT ) have also been implicated in the pathogenesis of high blood pressure, including those at nucleotides –6, –20, –217, –517, and –792 [ 5 , 6 ]. Human AGT , which is an important component of the renin–angiotensin system (RAS), is located on chromosome 1 (1q42–q43) and comprises 5 exons [ 7 ]. Angiotensinogen ( AGT ) is an important substrate

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Sex and salt intake dependent renin-angiotensin plasticity in the liver of the rat

. Iwai M, Horiuchi M. Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis. Hypertens Res 32, 533–536, 2009. Kammerl MC, Richthammer W, Kurtz A, Kramer BK. Angiotensin II feedback is a regulator of renocortical renin, COX-2, and nNOS expression. Am J Physiol Regul Integr Comp Physiol 282, 1613–1617, 2002. Kobori H, Harrison-Bernard LM, Navar LG. Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension. J Am Soc Nephrol 12, 431–439, 2001

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The angiotensinogen gene polymorphism, lifestyle factors, associated diseases and gastric areas of inflammatory and preneoplastic lesions in a Romanian sample of patients

-Pantoja A, Mejía-Pérez SI, Reynoso-Noverón N, Gómez-Flores-Ramos L, Soto-Reyes E, Sánchez-Correa TE, et al. Angiotensinogen rs5050 germline genetic variant as potential biomarker of poor prognosis in astrocytoma. PLoS One. 2018 Nov 1;13(11):e0206590; DOI: 10.1371/journal.pone.0206590 13. Lanza FL, Collaku A, Liu DJ. Endoscopic comparison of gastroduodenal injury with over-the-counter doses of new fast-dissolving ibuprofen and paracetamol formulations: a randomized, placebo-controlled, 4-way crossover clinical trial. Clin Exp Gastroenterol. 2018 Apr;11:169-77; DOI

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The role of eNOS and AGT gene polymorphisms in secondary pulmonary arterial hypertension in Romanian children with congenital heart disease

the migration of cultured vascular smooth muscle cells. Circ. Res. 1996; 78(2):225-230. 11. Garg UC, Hassid A. Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989; 83(5):1774-1777. 12. Say YH, Ling KH, Duraisamy G, Isaac S, Rosli R. Angiotensinogen M235T gene variants and its association with essential hypertension and plasma renin activity in Malaysian subjects: A case control study. BMC Cardiovascular

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Prognostic value of soluble angiotensin II receptor 1 and soluble angiotensin converting enzyme (CD 143) in patients with acute leukemia

primarily via angiotensinogen, angiotensin I (Ang I), and Ang II. The enzyme renin converts angiotensinogen to the decapeptide Ang I, which is transformed into the octapeptide Ang II by the exopeptidase angiotensin I-converting enzyme (ACE) [ 4 ]. Components of RAS are expressed in several adult organs including the liver, kidney, pancreas, brain and reproductive organs. It is the paracine mechanisms of locally expressed RAS, not in its circulating counterpart, that appear important for tumourigenesis [ 5 , 6 ]. Ang II is the main effector of the RAS and it alternatively

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Protective Effects of Aliskiren, Enalapril and Valsartan on Hypertension Target Organs in Spontaneously Hypertensive Rats

, Cumin F, et al. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens. 2005;23:417-26. Ganten D, Wagner J, Zeh K, et al. Species specificity of renin kinetics in transgenic rats harboring the human renin and angiotensinogen genes. Proc Natl Acad Sci USA. 1992;89:7806-10. Fukamizu A, Sugimura K, Takimoto E, et al. Chimeric reninangiotensin system demonstrates sustained increase in blood pressure of transgenic mice carrying both human

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Linkage Analysis by a Transmission/Disequilibrium Test of Russian Sibling Pairs with Coronary Artery Disease

-180. Caulfield M, Lavender P, Farrall M, Munroe P, Lawson M, Turner P, Clark AJ. Linkage of the angiotensinogen gene to essential hypertension. N Engl J Med 1994; 330(23): 1629-1633. Caulfield M, Lavender P, Newell-Price J, Farrall M, Kamdar S, Daniel H, Lawson M, De Freitas P, Fogarty P, Clark AJ. Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans. J Clin Invest 1995; 96(2): 687-692. Walker WG, Whelton PK, Saito H, Russell RP, Hermann J. Relationship between blood pressure and

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Association between angiotensin II type-1 receptor A1166C polymorphism and the presence of angiographically-defined coronary artery disease in an Iranian population

receptor gene and cardiovascular disorders. Ter Arkh. 2000; 72:27-30. 8. Chapman CML, Palmer LJ, McQuillan BM, Hung J, Burley J, Hunt C, et al. Polymorphisms in the angiotensinogen gene are associated with carotid intimal-medial thickening in females from a communitybased population. Atherosclerosis. 2001; 159:209-17. 9. Takami S, Imai Y, Katsuya T, Ohkubo T, Tsuji I, Nagai K, et al. Gene polymorphism of the renin-angiotensin system associates with risk for lacunar infarction: the Ohasama study. Am J Hypertens. 2000; 13

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Effects of Interactions among Gene Polymorphisms of the Renin–Angiotensin-Aldosterone System on Hypertension in Turkish People from Southeast Anatolia

References 1. Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Hibino T, et al. Assessment of the genetic component of hypertension. Am J Hypertens. 2006; 19(11):1158-65. DOI: 10.1016/j.amjhyper.2006.04.010 2. Tabassum N, Ahmad F. Role of natural herbs in the treatment of hypertension. Pharmacogn Rev. 2011; 5(9):30-40. DOI: 10.4103/0973-7847.79097 3. Bonfim-Silva R, GuimarAes LO, Souza Santos J, Perei-ra JF, Leal Barbosa AA, Souza Rios DL. Case-control association study of polymorphisms in the angioten-sinogen and angiotensin-converting enzyme

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Angiotensin-Converting Enzyme Genotype and Acute Pancreatitis in Turkey

Framingham Heart Study. Circulation 1998; 97(18): 1766-1772. Bengtsson K, Orho-Melander M, Lindblad U, Melander O, Bøg-Hansen E, Ranstam J, Råstam L, Groop L. Polymorphism in the angiotensin converting enzyme but not in the angiotensinogen gene is associated with hypertension and type 2 diabetes: the Skaraborg Hypertension and Diabetes Project. J Hypertens 1999; 17(11): 1569-1575.

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