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4. MURARO A, PAPADOPOULOS NG. Skin prick test at the European Parliament and Written Declaration on Recognising the Burden of Allergic Diseases . EAACI 2014; Newsletter 34 ;1.
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6. CHIVATO T, VALOVIRTA E, DAHL R, DE MONCHY J, BLOCH THOMSEN A, PALKONEN S, et al . Allergy, Living and Learning: Diagnosis and treatment of allergic
Polliana Mihaela Leru, Ana-Maria Eftimie and Michel Thibaudon
Conference of Romanian Society of Allergology and Clinical Immunology, 2013.
5. BURBACH GJ, HEINZERLING LM, EDENHARTER G, BACHERT C, BINDSLEV-JENSEN C, BONINI S et al . GA2LEN skin test study II: Clinical relevance of inhalant allergen sensitizations in Europe . Allergy 2009, 64(10), 1507-1515.
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8. IANOVICI N. Research Report “Aerobiological analysis
Miroslav Ž. Dinić, Lidija Kandolf-Sekulović and Radoš D. Zečević
One hundred years of dermatovenereology of the Serbian Army was celebrated on November 7, 2009, in the amphitheatre of the Military Medical Academy (MMA). The oldest document in possession of the Serbian Armed ForcesMedical Services is dated on St. George’s Day, May 6th, 1869 and represents a “Daily report of military hospitals”. This document clearly shows the number of patients, and what they suffered from. Moreover, this document shows, among other things, how many patients were suffering from “venereal diseases, red wind, mechanical injuries, base wounds, ulcers, lichen and mange“. Until 1909, the Department of Dermatovenereology did not exist as an independent. Today, the Clinic has 2 divisions (a total of 36 beds), as well as the Laboratory for immunodermatology, Surgical unit, GeneralDermatology Outpatient Clinic, Allergology Section, Phototherapy Section, Dermoscopy and Melanoma Outpatient Clinic. The Clinic is the leader in the treatment of psoriasis, autoimmune skin diseases (pemphigus, pemphigoid), severe forms of atopic dermatitis, erythroderma, skin lymphomas and cutaneous manifestations of connective tissue diseases (lupus, dermatomyositis, sclerodermia), and a dermatologic oncology section is being developed, where systemic therapy of melanoma and follow-up of these patients will be done. Regarding the vision of the future, the main task of the Clinic is to ensure continuous improvement in the field of dermatology in Serbia. The plan is to develop the area of photodiagnostics and phototherapy, which are insufficient in the region. Also, further development of dermatological surgery is planned. Further development of Allergology Service is mandatory, as well as establishment of Pediatric Dermatology, Phlebology and Trichology Outpatient Clinic. Continued scientific research is essential for the development of an academic institution and a prerequisite for continuous diagnostic and therapeutic progress, and a permanent pursuit.
1. Samoliński B, Raciborski F, Lipiec A i wsp. Epidemiologia chorób alergicznych w Polsce (ECAP). Alergologia Polska-Polish Journal of Allergology. 2014;1(1): 10-18. doi: https://doi.org/10.1016/j.alergo.2014.03.008 .
2. The European Academy of Allergy and Clinical Immunology 2015. Pobrane z: https://www.eaaci.org/documents/EAACI_Advocacy_Manifesto.pdf (dostęp: 1.09.2019)
3. Gawlik R, Zagórny G, Bożek A. Farmakoekonomiczne aspekty zastosowania immunoterapii alergenowej w leczeniu alergicznego nieżytu nosa i astmy
Svetlan M. Dermendzhiev, Radostina Simeonova and Marianna A. Murdjeva
INTRODUCTION: Systemic allergic reactions, which include angioedema, are very common in clinical practice. There is great diversity in the etiological factors known to trigger angioedema, and in the pathogenetic mechanisms defi ning this condition. Beside the broad spectrum of immuno-allergic reactions involved in the angioedemic pathogenesis, this condition is known to also develop on the background of other disorders. These disorders may be of different etiology and have different pathogenesis (either non-immune or immune) but have one common feature referred to as “serological overlap”. From research and clinical perspective, it is interesting to explore the combination of some rare neurological diseases, such as myopathies and in particular muscular dystrophies with systemic allergic reactions such as angioedema, urticaria and others. It is known that progressive muscular dystrophies (PMD) are hereditary diseases with different types of inheritance - X-chromosome recessive, X-chromosome dominant, autosomal dominant and others. In some forms, such as Duchenne muscular dystrophy (DMD), an increased expression of perforin in muscle is found which is evidence for involvement of the cellular immune response in the pathogenesis of myopathy. It is in this sense that it is interesting to explore and discuss a clinical case diagnosed as a facioscapulohumeral form of PMD, which also manifests angioedema with urticaria.
CASE PRESENTATION: We present a 41-year-old male hospitalized in the Division of Occupational Diseases and Allergology at St. George University Hospital in Plovdiv who suffered two incidents of massive angioedema on the face, back and chest, accompanied by an itchy urticarial rash. In 1985, after hospitalization to the Clinic of Neurology, he was diagnosed with PMD of facioscapulohumeral type. The medical history could not reveal any of the most common etiologic factors such as drugs, food, insects and other allergens that may be associated with the systemic allergic reactions. The abnormalities we found (although they are only of specifi c indices of humoral immunity) give some reasons to assume the hypothesis of possible causation between the primary neurological disorder as a trigger for this kind of allergy.
CONCLUSION: The reported case demonstrates that in addition to the cellular immunity abnormalities we identifi ed, the abnormalities in some components of humoral immunity should also be taken into consideration. Good knowledge of the allergic factors and the mechanisms of allergic reactions is of paramount importance for an effi cacious approach to the problems faced by patients with such rare pathology.
A. I. Onishchenko, A. S. Tkachenko, I. M. Kalashnyk, V. L. Tkachenko, O. A. Nakonechna and G. I. Gubina-Vakulyck
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: A clinical diagnosis. Otolaryngology – Head and Neck Surgery 2009; 141(3): 418–419.
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