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Multidrug resistance gene 1 polymorphisms in pediatric patients with leukemia at a national referral hospital in Indonesia

[ 2 ]. The most common malignancy in the pediatric population worldwide is acute lymphoblastic leukemia (ALL). ALL is a heterogeneous group of leukemias that result from the clonal proliferation of cancerous lymphoblasts in bone marrow, and in secondary lymphoid organs. Children 1–10 years old are at particular risk of developing ALL. The overall cure rate is approximately 80% [ 3 ]. The Indonesian Paediatric Oncology Foundation stated that 2%-3% cancer cases in Indonesia occur in children [ 4 ]. Based on Cipto Mangunkusumo Hospital data from 2000-2006, there were

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Relevant nursing measures for the adverse reactions associated with chimeric antigen receptor T cells (CAR-T) immunotherapy: a systematic review of case reports

immunotherapy for refractory acute lymphocytic leukemia. Chin J Blood Transfusion. 2016;29:1104-1107 (in Chinese). Chen XL Feng YM Zeng YJ Exploration of integrated nursing care on CAR-T cell immunotherapy for refractory acute lymphocytic leukemia Chin J Blood Transfusion 2016 29 1104 1107 (in Chinese) 15 Feng N, Du X, Zhang C, Hao J, Zeng L. Nursing care of patients with recurrent refractory acute lymphoblastic leukemia treated with chimeric antigen receptor. Chongqing Med. 2016;45:140-141 (in Chinese). Feng N Du X Zhang C Hao J Zeng

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Original article. Efficacy of intravenous dexamethasone for the prevention of vomiting associated with intrathecal chemotherapy and ketamine sedation in children: a randomized, double-blinded, crossover, placebocontrolled trial

References 1. Onciu M. Acute lymphoblastic leukemia. Hematol Oncol Clin North Am. 2009; 23:655-74. 2. Pui CH, Campana D, Pei D, Bowman WP, Sandlund JT, Kaste SC, et al. Treating childhood acute lymphoblastic leukemia without cranial irradiation N Engl J Med. 2009; 360:2730-41. 3. Holdsworth MT, Raisch DW, Winter SS, Chavez CM. Assessment of the emetogenic potential of intrathecal chemotherapy and response to prophylactic treatment with ondansetron. Support Care Cancer. 1998; 6:132-8. 4. Langston

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Gene polymorphisms and diseases in Asians

varies between different ethnic groups. These are explained by genetic variation and susceptibility to disease process. Because variations in the genome occur randomly, certain types of mutation and polymorphism exist in particular ethnic groups. Therefore, when a particular genomic variation and disease association is identified, there is a need to verify usefulness in ethnic groups. Two examples from this issue of the journal illustrate this topic. Acute lymphoblastic leukemia (ALL) is one of the most curable cancers of childhood. The cure is attributed to risk

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Radiation dose from CT scanning: can it be reduced?

; 29: A43-59. 15. Hoffman DA, Lonstein JE, Morin MM, Visscher W, Harris BS 3 rd , Boice JD Jr. Breast cancer in women with scoliosis exposed to multiple diagnostic X-rays. J Natl Cancer Inst. 1989, 81: 1307-12. 16. Doody M, Lonstein JE, Stovall M, Hacker DJ, Luckyanov N, Land CE. Breast cancer mortality after diagnostic radiography: findings from the U.S. Scoliosis Cohort Study. Spine. 2000; 25: 2052-63. 17. Infante-Rivard C. Diagnostic x rays, DNA repair genes and childhood acute lymphoblastic leukemia. Health Phys

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MicroRNAs: potential regulators of airway smooth muscle cell plasticity involved in asthma-induced airway remodeling

, Chen S, et al. miR-155 and its star-form partner miR-155* cooperatively regulate type I interferon production by human plasmacytoid dendritic cells. Blood. 2010; 116:5885-94. 33. Zhang Y, Liu D, Chen X, Li J, Li L, Bian Z, et al. Secreted monocytic miR-150 enhances targeted endothelial cell migration. Mol Cell. 2010; 39:133-44. 34. Rainer J, Ploner C, Jesacher S, Ploner A, Eduardoff M, Mansha M, et al Glucocorticoid-regulated microRNAs and mirtrons in acute lymphoblastic leukemia. Leukemia. 2009; 23:746-52. 35. Havens

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