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Spatial relationship between the c-Fos distribution and enkephalinergic, substance P, and tyrosine hydroxylase innervation fields after acute treatment with neuroleptics olanzapine, amisulpride, quetiapine, and aripiprazole in the rat septum

strategies beyond dopamine receptor antagonism. CNS Drugs 29, 773–799, 2015. DeVries GJ, Buijs RM. The origin of the vasopressinergic and oxytocinergic innervation of the rat brain with special reference to the lateral septum. Brain Res 273, 307–317, 1983. Gall C, Moore RY. Distribution of enkephalin, substance P, tyrosine hydroxylase, and 5-hydroxytriptamine immunoreactivity in the septal region of the rat. J Comp Neurol 225, 212–227, 1984. Goodnick PJ, Jerry JM. Aripiprazole: profile on efficacy and safety. Expert Opin Pharmacother 3, 1773–1781, 2002

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Eff ect of a single asenapine treatment on Fos expression in the brain catecholamine-synthesizing neurons: impact of a chronic mild stress preconditioning

References Asmus SE, Newman SW. Colocalization of tyrosine hydroxylase and Fos in the male Syrian hamster brain following diff erent states of arousal. J Neurobiol 25, 156-168, 1994. Berridge CW, Waterhouse BD. Th e locus coeruleus-noradrenergic system: modulation of behavioral state and statedependent cognitive processes. Brain Res Rev 42, 33-84, 2003. Bjorklund A, Nobin A. Fluorescence histochemical and microspectrofl uorometric mapping of dopamine and noradrenaline cell groups in the rat diencephalon. Brain

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Biomolecular changes and cortical neurodegenerative lesions in Trichinella spiralis infected BALB/c mice: a preliminary study elucidating a potential relationship between systemic helminthic infections and idiopathic Parkinson’s

Parkinson Disease. J. Parkinsons Dis., 5(1):1 - 19. Doi: 10.3233/Jpd-140491 Andersen, J.K. (2004): Oxidative Stress In Neurodegeneration: Cause Or Consequence? Nat. Med., 2004: S18 - 25. Doi: 10.1038/Nrn1434 Asmus, S.E., Anderson, E.K., Ball, M.W., Barnes, B.A., Bohnen, A.M., Brown, A.M., Hartley, L.J., Lally, M.C., Lundblad, T.M., Martin, J.B., Moss, B.D., Phelps, K.D., Phillips, L.R., Quilligan, C.G., Steed, R.B., Terrell, S.L., Warner, A.E. (2008): Neurochemical Characterization Of Tyrosine Hydroxylase-Immunoreactive Interneurons In The

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Continuous cold exposure induces an anti-inflammatory response in mesenteric adipose tissue associated with catecholamine production and thermogenin expression in rats

Abstract

Objective. Continuous exposure to cold leads to an activation of adaptive thermogenesis in the brown adipose tissue and induction of brown/beige cell phenotype in the white adipose tissue. Thermogenic response is associated with alternatively activated macrophages producing catecholamines, which subsequently activate the uncoupling protein 1 (UCP-1). The aim of this work was to elucidate the effect of cold exposure on catecholamine and immune responses associated with adipocyte browning in the mesenteric adipose tissue (mWAT) of rat.

Methods. The rats were exposed to continuous cold (4 °C) for 1 or 7 days. Catecholamines production and gene expressions of inflammatory and other factors, related to adipocyte “browning”, were analyzed in the homogenized mWAT samples using 2-CAT ELISA kits.

Results. Cold exposure induced a sympathetic response in the mWAT, evidenced by the tyrosine hydroxylase (TH) protein level rise. Induction of non-sympathetical catecholamine production was observed 7 days after cold exposure by elevated TH and phenylethanolamine-N-methyltransferase (PNMT) expression, leading to an increased epinephrine levels. Cold exposure for 7 days stimulated the infiltration of macrophages, evaluated by F4/80 and CD68 expressions, and expression of anti-inflammatory mediators, while pro-inflammatory cytokines were inhibited. Anti- inflammatory response, accompanied by de novo catecholamine production and up-regulation of β3-adrenergic receptors, led to the stimulation of UCP-1 and PGC1α expression, suggesting a cold-induced “browning” of the mWAT, mediated by alternatively activated macrophages.

Conclusions. The present data indicate that prolonged cold exposure may induce anti-inflammatory response in mWAT associated with induction of UCP-1 expression. Although functional thermogenesis in the mWAT is most likely redundant, a highly efficient dissipation of energy by UCP1 may affect the energy homeostasis in this visceral fat.

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Antidepressant effects of valproic acid in an animal model of depression

] Lima IVA, Almeida-Santos AF, Ferreira-Vieira TH, Aguiar DC, Ribeiro FM, Campos AC, de Oliveira ACP. Antidepressant-like effect of valproic acid-Possible involvement of PI3K/Akt mTOR pathway. Behav Brain Res. 2017; 329:166-171. [7] Pistovcakova J, Dostalek M, Sulcova A, Jezova D. Tiagabine treatment is associated with neurochemical, immune and behavioural alterations in the olfactory bulbectomized rat model of depression. Pharmacopsychiatry. 2008; 41(2):54-9. [8] Qiu HM, Yang JX, Jiang XH, Hu XY, Liu D, Zhou QX. Enhancing tyrosine hydroxylase and

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Modulating Effects of Cholecalciferol Treatment on Estrogen Deficiency-Induced Anxiety-Like Behavior of Adult Female Rats

increases glial cell line-derived neurotrophic factor and partially restores tyrosine hydroxylase expression in substantia nigra and striatum. J Neurosci Res 2009;87:723-32. 30. Stanzione P, Calabresi P, Mercuri N, et al. Dopamine modulates CA1 hippocampal neurones by elevating the threshold for spike generation: an in vitro study. Neuroscience 1984;13:1105-16. 31. Pick U, Haramaki N, Constantinescu A, et al. Glutathione reductase and lipoamide dehydrogenase have opposite stereospecificities for α-lipoic acid enantiomers. Biochem Biophys Res Commun 1995

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Developmental study of mercury effects on the fruit fly (Drosophila melanogaster)

activation of the JNK signaling pathway by mechanical stress. PLoS ONE 6 : e26182. Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR .(2009). Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells. J Neurochem 110 : 848-856. Rand MD, Dao JC, Clason TA. (2009). Methylmercury disruption of embryonic neural development in Drosophila. Neurotoxicology 30 : 794-802. Sackton KL, Buehner NA, Wolfner MF. (2007). Modulation of MAPK activities during egg activation

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Effect of chronic treatment with angiotensin receptor ligands on water-salt balance in wistar and spontaneously hypertensive rats

+-K+-ATPase activity via a NO/cGMP-dependent pathway. Am J Physiol Renal Physiol 2006;290:1430. 24. Macova M, Pavel J, Saavedra JM. A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH. Brain Res 2009;1250:130-40. 25. Giebisch G. Renal potassium transport: mechanisms and regulation. Am J Physiol Renal Physiol 1998;274:817-33. 26. Reilly RF, Ellison DH. Mammalian distal tubule

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Catha Edulis Active Principle, Cathinone, Suppresses Motor Coordination, Accelerates Anxiety and Alters the Levels of Dopamine and its Metabolites in the Limbic Areas of Male Swiss Albino Mice

.1016/0376-8716(82)90067-9 15. N. D. Volkow, J. S. Fowler, G. J. Wang, J. M. Swanson and F. Telang. Dopamine in drug abuse and addiction: results of imaging studies and treatment implications, Arch. Neurol. 64 (2007) 1575-1579. 16. J. Nielsen, Cathinone affects dopamine and 5-hydroxytryptamine neurons in vivo as measured by changes in metabolites and synthesis in four forebrain regions in the rat, Neuropharmacology 24 (1985) 845-852; https://doi.org/10.1016/0028-3908(85)90035-8 17. S. C. Daubner, T. Le and S. Wang, Tyrosine hydroxylase and regulation of

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Enkephalinase activity is modified and correlates with fatty acids in frontal cortex depending on fish, olive or coconut oil used in the diet

, Lacort M, Matorras R, Ruiz-Larrea MB. 17beta-estradiol affects in vivo the low density lipoprotein composition, particle size, and oxidizability. Free Radic Biol Med 31, 391–397, 2001. Schommer J, Marwarha G, Nagamoto-Combs K, Ghribi O. Palmitic acid-enriched diet increases α-sSynuclein and tyrosine hydroxylase expression levels in the mouse brain. Front Neurosci 12, 552, 2018. Segarra AB, Ramirez M, Banegas I, Alba F, Vives F, de Gasparo M, Ortega E, Ruiz E, Prieto I. Dietary fat influences testosterone, cholesterol, aminopeptidase A, and blood pressure in

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