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the recent years that help in the advancement of biological research through the use of different algorithms and databases ( 18 ). Many researches about the role of CDC73 gene in the development of (HPT-JT) syndrome have focused in the deletion type of mutation ( 5 , 19 , 20 ), yet few of them have study single nucleotides polymorphisms (SNPs). This study is unique because it is the first in silico analysis of CDC73 gene associating it with jaw tumor syndrome. Therefore, the aim of this study is to assess the effect of mutational SNPs on CDC73 gene on the

cold damage in a warming world. BioScience 58: 253-262. HALL, T. A. (1999): BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95/98/NT. Nucleic Acids Symposium Series 41: 95-98. HELYAR, S. J., J. HEMMER-HANSEN, D. BEKKEVOLD, M. I. TAYLOR, R. OGDEN, M. T. LIMBORG, A. CARIANI, G. E. MAES, E. DIOPERE, G. R. CARVALHO and E. E. NIELSEN (2011): Application of SNPs for population genetics of nonmodel organisms: new opportunities and challenges. Molecular Ecology Resources 11: 123-136. HEMMER-HANSEN, J., E. E. G. NIELSEN, D

References Lang UE, Puls I, Muller DJ, Strutz-Seebohm N, Gallinat J. Molecular mechanisms of schizophrenia. Cell Physiol Biochem 2007; 20(6): 687-702. McGuffin P. Gene polymorphisms and behaviour. Pediatr Blood Cancer 2007; 48(7): 736-737. Kurland L, Liljedahl U, Lind L. Hypertension and SNP genotyping in antihypertensive treatment. Cardiovasc Toxicol 2005; 5(2): 133-142. Ayme S. Bridging the gap between molecular genetics and metabolic medicine: access to genetic information. Eur J Pediatr 2000; 159(Suppl 3): S183-185. Shi MM. Enabling large

References Baird NA, Etter PD, Atwood TS, Currey MC, Shiver AL, Lewis ZA, Selker EU, Cresko WA, Johnson EA (2008) Rapid SNP discovery and genetic mapping using sequenced RAD markers. PLoS One 3(10). Bastow M (2018) Quercus mongolica. The IUCN Red List of Threatened Species 2018. Blanc-Jolivet C, Yanbaev Y, Kersten B, Degen B (2018) A set of SNP markers for timber tracking of Larix spp. in Europe and Russia. Forestry 91(5):614-628

. Landbauforschung - vTI Agriculture and Forestry Research 321: 6-14. ECKENWALDER, J. E. (1996): Systematics and evolution of Populus, pp 7-32. In: Biology of Populus and its Implications for Management and Conservation Part I, Chapter 1, edited by R. F. STETTLER, H. D. BRADSHAW JR, P. E. HEILMAN and T. M. HINCKLEY, NRC Research Press, National Research Council of Canada, Ottawa, ON, Canada. FLADUNG, M. and J. BUSCHBOM (2009): Identification of Single Nucleotide Polymorphisms (SNPs) in different Populus species. Trees 23: 1199-1212. GARCIA-GIL, M. R., M. MIKKONEN and O. SAVOLAINEN

References A chere , V., P. F aivre R ampant , L. E. P aques and D. P rat (2004): Chloroplast and mitochondrial molecular tests identify European x Japanese larch hybrids. Theoretical Applied Genetics 108 : 1643–1649. A itken , N., S. S mith , C. S chwarz and P. A. M orins (2004): Single nucleotide polymorphism (SNP) discovery in mammals: a targeted-gene approach. Molecular Ecology 13 : 1423–1431. B atley , J., R. M ogg , D. E dwards , H. O’S ullivan and K. J. E dwards (2003): A high-throughput SNuPE assay for genotyping SNPs in the flanking regions of

SNPs affecting bovine leukemia virus infection level in dairy cattle. BMC Genomics., 19: 142. Choi J.W., Liao X., Stothard P., Chung W.H., Jeon H.J., Miller S.P., Choi S.Y., Lee J.K., Yang B., Lee K.T., Han K.J., Kim H.C., Jeong D., Oh J.D., Kim N., Kim T.H., Lee H.K., Lee S.J. (2014). Whole-genome analyses of Korean native and Holstein cattle breeds by massively parallel sequencing. PLoS One., 9: e101127. Ciani E., Crepaldi P., Nicoloso L., Lasagna E., Sarti F.M., Moioli B., Napolitano F., Carta A., Usai G., D’Andrea M., Marletta D., Ciampolini R., Riggio V

nicotine-dependence may affect the development of COPD. In addition, nicotine-dependence can be considered as the most significant factor for smoking cessation [ 4 ]. Nicotinic acetylcholine receptors, or nAChRs, are receptor polypeptides that respond to the neurotransmitter acetylcholine [ 5 ]. Nicotine, a major component of tobacco, is the main cause of tobacco addiction that acts through nAChRs. At present, genome-wide association studies have proved that several single nucleotide polymorphisms (SNPs) (rs1051730, rs16969968, rs8034191 and rs4950) in two nAChRs ( CHRNA Lima BM (2014) Bridging genomics and quantitative genetics of Eucalyptus: genome-wide prediction and genetic parameter estimation for growth and wood properties using high-density SNP data. PhD (Disertation) – Escola Superior de Agricultura “Luiz de Queiroz”, Universidade de São Paulo, Piracicaba. Available at http://10.11606/T.11.2014.tde-25062014-085814 Maia M, Resende MDV, Paiva JR, Cavalcanti JJV, Barros LM (2009) Seleção simultânea para produção, adaptabilidade e estabilidade genotípicas em clones de cajueiro, via

properties in natural populations and land races of Pinus radiata. Genet 185: 1477-1487. DILLON, S. K., M. NOLAN, P. MATTER, J. BRAGG, W. J. GAPARE and S. G. SOUTHERTON (2013): Signatures of adaptation and genetic structure among the mainland populations of Pinus radiata D. Don inferred from SNP loci. Tree Genet. Genomes 9: 1447-1463. DOYLE, J. J. and J. L. DOYLE (1990): Isolation of plant DNA from fresh tissue. Focus 12: 13-15. DUNGEY, H. S., J. T. BRAWNER, F. BURGER, M. CARSON, M. HENSON, P. JEFFERSON and A. C. MATHESON (2009): A new breeding strategy for Pinus radiata