Elena Andrus, Anca Nicolescu, H. Bumbea and Ana-Maria Vlădăreanu
We present the case of a 71-year-old woman diagnosed with chronic lymphocytic leukemia who received multiple chemotherapeutic lines and evolved to acute lymphoblastic leukemia. The patient was Rai stage 0 at the time of the diagnosis and was monitored for almost 9 years. After that, the disease progressed and the patient began chemotherapy (fludarabine/cyclophosphamide combination), obtained complete remission and relapsed one year later after finishing treatment. She received multiple therapeutic regimens, accompanied by multiple infectious complications. After 8 years of evolution since she started chemotherapy, bone marrow aspirate and immunophenotyping revealed acute lymphoblastic leukemia. The occurrence of acute leukemia in CLL is rare and may arise from the same clone; however, most cases appear after patients have received chemotherapy, suggesting that they are therapy-related.
A Pazarbaşi, M Kasap, O Demirhan, M Vardar, D Suleymanova-Karahan and F Doran
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Santulli B, Kazmierczak B, Napolitano R, Caliendo I, Chiappetta G, Rippe V, Bullerdiek J, Fusco A. A 12q13 translocation involving the HMGI-C gene in richtertransformation of a chronic lymphocytic leukemia. Cancer Genet Cytogenet 2000; 119(1): 70-73.
Yeh YA, Rao PH, Cigna CT; Middlesworth W, Lefkowitch JH, Murty VVVS. Trisomy 1q, 2 and 20 in a
Emilia Rymkiewicz, Agnieszka Piebiak, Beata Chrapko, Justyna Szumiło, Norbert Grząśko and Krzysztof Giannopoulos
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