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Acute Lymphoblastic Leukemia after previously treated, relapsed Chronic Lymphocytic Leukemia: A Case Report

Abstract

We present the case of a 71-year-old woman diagnosed with chronic lymphocytic leukemia who received multiple chemotherapeutic lines and evolved to acute lymphoblastic leukemia. The patient was Rai stage 0 at the time of the diagnosis and was monitored for almost 9 years. After that, the disease progressed and the patient began chemotherapy (fludarabine/cyclophosphamide combination), obtained complete remission and relapsed one year later after finishing treatment. She received multiple therapeutic regimens, accompanied by multiple infectious complications. After 8 years of evolution since she started chemotherapy, bone marrow aspirate and immunophenotyping revealed acute lymphoblastic leukemia. The occurrence of acute leukemia in CLL is rare and may arise from the same clone; however, most cases appear after patients have received chemotherapy, suggesting that they are therapy-related.

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Chromosomal Abnormalities in Endometrial and Ovarian Carcinomas

-106. Stock AD, Dennis TR. A translocation breakpoint at chromosome band 12q13 associated with B-cell chronic lymphocytic leukemia. Cancer Genet Cytogenet 1999; 111(2): 166-168. Santulli B, Kazmierczak B, Napolitano R, Caliendo I, Chiappetta G, Rippe V, Bullerdiek J, Fusco A. A 12q13 translocation involving the HMGI-C gene in richter transformation of a chronic lymphocytic leukemia. Cancer Genet Cytogenet 2000; 119(1): 70-73. Yeh YA, Rao PH, Cigna CT; Middlesworth W, Lefkowitch JH, Murty VVVS. Trisomy 1q, 2 and 20 in a

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Diagnostyka gorączki u pacjentki z rozpoznaniem przewlekłej białaczki limfocytowej

R Fernandes J et al Fludarabine (FAMP) and risk of occurrence of Richter’s syndrome among B-CLL Blood 2000 96 295 17 Wang Y, Tschautscher M, Rabe K, et al. Clinical characteristics and outcomes of Richter transformation: experience of 204 patients from a single center. Haematol 2019.224121 [Epub ahead of print]. Wang Y Tschautscher M Rabe K et al Clinical characteristics and outcomes of Richter transformation: experience of 204 patients from a single center Haematol 2019 224121 Epub ahead of print 18 Parikh S, Rabe K, Call T

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