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Prunella vulgaris L. belongs to the genus Prunella, Lamiaceae family, Nepetoideae subfamily. In Romania, the genus Prunella includes Prunella vulgaris L., Prunella grandiflora (L.) Jacq and Prunella laciniata L.. Amongst these, Prunella vulgaris is of particular importance, having numerous pharmacological actions. The purpose of this study is to analyze macroscopically and microscopically the main characters by which Prunellae spica can be identified and distinguished from other fruit-spikes from species of the Lamiaceae family.