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Compaction Behaviour Modelling of Metal-Ceramic Powder Mixtures. A Review

Abstract

Powder mixtures compaction behavior can be quantitatively expressed by densification equations that describe the relationship between densities - applied pressure during the compaction stages, using correction factors. The modelling of one phase (metal/ceramic) powders or two-phase metal-ceramic powder composites was studied by many researchers, using the most commonly compression equations (Balshin, Heckel, Cooper and Eaton, Kawakita and Lüdde) or relative new ones (Panelli - Ambrózio Filho, Castagnet-Falcão- Leal Neto, Ge Rong-de, Parilák and Dudrová, Gerdemann and Jablonski. Also, for a better understanding of the consolidation process by compressing powder blends and for better prediction of compaction behavior, it's necessary the modeling and simulation of the powder pressing process by computer numerical simulation. In this paper are presented the effect of ceramic particles additions in metallic matrix on the compressibility of composites made by P/M route, taking into account (a) the some of above mentioned powder compression equations and also (b) the compaction behavior modeling through finite element method (FEM) and discrete element modeling (DEM) or combined finite/ discrete element (FE/DE) method.

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Development of directly compressible metformin hydrochloride by the spray-drying technique

-168. J. Staniforth, Powder flow , in Pharmaceutics: The Science of Dosage Form Design (Ed. M. E. Aulton), 2nd ed., Churchill Livingstone, London 2002, pp. 197-210. R. W. Heckel, Density-pressure relationship in powder compaction, Trans. Metal. Soc. AIME   221 (1961) 671-675. R. W. Heckel, An analysis of powder compaction phenomena, Trans. Metal. Soc. AIME   221 (1961) 1001-1008. K. Kawakita and K. H. Ludde, Some consideration of powder compression equations, Powder Tehnol.   4 (1971

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Analysis of Pharmaceutical Excipient MCC Avicel PH102 Using Compaction Equations

-33 [12] GABAUDE, C., GUILLOT, M., GAUTIER, J.C.: Effects of true density, compacted mass, compression speed, and punch deformation on the mean yield pressure. Journal of Pharmaceutical Sciences, 88 , 1999, pp. 725-730 [13] HAN, L.H., ELLIOT, J.A., BENTHAM, A.C., MILLS, A. AMIDON, G.E.: A modified Drucker-Prager Cap model for die compaction simulation of pharmaceutical powders. International Journal of Solid and Structures , 45 , 2008, pp. 3088-3106 [14] KAWAKITA, K.: Some considerations on powder compression equations. Powder Technology, 4 , 1971

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Compressional, mechanical and release properties of a novel gum in paracetamol tablet formulations

. Matrix properties of a new plant gum in controlled drug delivery. Arch. Pharmacal Res., 30(7), 884, 2007. 24. Kawakita K., Lüdde K. H. Some considerations on powder compression equations. Powder Tech., 4, 61, 1970/71. 25. Kitazawa S., et al.: Effects of hardness on the disintegration and dissolution rate of uncoated caffeine tablets. J. Pharm. Pharmacol., 27(10), 765, 1975. 26. Luangtana-Ana M, Fell J T.: Bonding mechanisms in tabletting. Int. J. Pharm., 60, 197, 1990. 27. Noyes A. A., Whitney W. R.: The

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Application of instrumented nanoindentation in preformulation studies of pharmaceutical active ingredients and excipients

.09.080. 20. R. W. Heckel, An analysis of powder compaction phenomena, Trans. Metall. Soc. AIME 221 (1961a) 1001-1008. 21. R. W. Heckel, Density-pressure relationships in powder compaction, Trans. Metall. Soc. AIME 221 (1961b) 671-675. 22. E. E. Walker, The properties of powders VI: The compressibility of powders. Trans. Faraday Soc. 19 (1923) 73-82; DOI: 0.1039/tf9231900073. 23. K. Kawakita and K. H. Ludde, Some consideration on powder compression equations, Powder Technol. 4 (1971) 61-68; DOI: 10

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