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Sci Sports, 2005 Aug; 15(4): 252-9. Almdahl SM, Veel T, Halvorsen P, Vold MB, Molstad Pl. Randomized prospective trial of saphenous vein harvest site infection after wound closure with and without topical application of autologous platelet-rich plasma. Eur J Cardiothorac Surg, 2011 Jan; 39(1): 44-48. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost, 2004 Jan; 91: 4-15. Bielecki TM, Gazdzik TS, Arendt J, Szczepanski T, Król W, Wielkoszynski T. Antibacterial effect of

References 1. Sokolov, T., А. Manukova, S. Karakoleva, B. Valentinov, N. Petrova. Analysis of the Results of Applying the Method Platelet-Rich Plasma (PRP) for the Treatment of Problematic Skin Wounds. – J. of IMAB, Vol. 23 , 2017, No 1, pp. 1460-1465. 2. Gottrup, F., T. Karlsmark. Leg Ulcers: Uncommon Presentations. – Clin. Dermatol., Vol. 23 , November-December 2005, No 6, pp. 601-611. 3. Anitua, E., J. J. Aguirre, J. Algorta, E. Ayerdi, A. Cabezas, G. Orive, I. Andia. Effectiveness of Autologous Preparation Rich in Growth Factors for the Treatment of

References 1. Pratt CH, King LE Jr, Messenger AG, Christiano AM, Sundberg JP. Alopecia areata. Nat Rev Dis Primers. 2017;3:17011. 2. Falto-Aizpurua L, Choudhary S, Tosti A. Emerging treat ments in alopecia. Expert Opin Emerg Drugs. 2014; 19(4):545-56. 3. Maria-Angeliki G, Alexandros-Efstratios K, Dimitris R, Konstantinos K. Platelet-rich plasma as a potential treatment for noncicatricial alopecias. Int J Trichology. 2015;7(2):54-63. 4. Uebel CO, da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery

. Cecillio C.A., Costa E.H., Simioni P.U., Gabriel D.L., Tamashiro W.M.S.C.: Aging alters the production of iNOS, arginase, and cytokines in murine macrophages. Braz J Med Biol Res 2011, 44, 671–681. 7. Corraliza I.M., Campo M.L., Soler G., Modolell M.: Determination of arginase activity in macrophages: a micromethod. J Immunol Methods 1994, 174, 231–235. 8. Czakai K., Dittrich M., Kaltdorf M., Müller T., Krappmann S., Schedler A., Bonin M., Dühring S., Schuster S., Speth C., Rambach G., Einsele H., Dandekar T., Löffler K.J.: Influence of platelet-rich plasma on the immune

., 59, 936–944. 4. Hayami T. (2008). Osteoarthritis of the knee joint as a cause of musculoskeletal ambulation disability symptom complex (MADS) , Clin. Calcium, 18,1574–80. 5. Filardo G., Kon E., Roffi A., Di Matteo B., Merli M.L., Marcacci M. (2015). Platelet-rich plasma: why intraarticular? A systematic review of preclinical studies and clinical evidence on PRP for joint degeneration , Knee Surg. Sports Traumatol. Arthrosc., 23(9), 2459–2474. 6. Sakata R., McNary S.M., Miyatake K., et al. (2015). Stimulation of the superficial zone protein and lubrication in the

of growth. J Cell Physiol Suppl 1987; Suppl 5: 31-4. 8. Anitua E, Andia I, Ardanza B, Nurden P, Nurden AT. Autologous platelets as a source of proteins for healing and tissue regeneration. Thromb Haemost 2004; 91: 4-15. 9. Mehta S, Watson JT. Platelet rich concentrate: basic science and current clinical applications. J Orthop Trauma 2008; 22: 432-8. 10. Marx RE. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant dent 2001; 10: 225-8. 11. Weiler A, Forster C, Hunt P, Falk R, Jung T, Unterhauser FN, et al. The influence of locally

REFERENCES 1. Попов Н. Кинезиология и патокинезиология на опорнодвигателния апарат, НСА – Прес, София, 2009, 311. 2. Guney Ah., M. Akar, I. Karaman et al. Clinical outcomes of platelet-rich plasma (PRP) as an adjunct to microfracture surgery in osteochondral lesions of the talus; Knee surgery; Sports traumatology, Arthroscopy, August 2015, Volume 23, Issue 8, pp: 2384-2389. 3. Levangie P., C. Norkin. Joint Structure and Function, fifth edition; A Comprehensive Analysis; F.A Davis Company, 2011, 440. 4. Looze Ch., J. Capo, M. Ryan. Evaluation and Management of

randomized trial of treatment for acute anterior cruciate ligament tears. N Engl J Med. 2010; 363: 331-42. 4. Anitua M, Sanchez E, Nurden A, Orive G, Andía I. New insights into and novel applications for platelet - rich fibrin therapies. Trends Biotechnol. 2006; 24: 227-34. 5. Gibbs N, Diamond R, Sekyere EO, Thomas WD. Management of knee osteoarthritis by combined stromal vascular fraction cell therapy, platelet-rich plasma, and musculoskeletal exercises: a case series. J Pain Res. 2015; 8: 799-806. 6. Duif C, Vogel T, Topcuoglu F, Spyrou G, von Schulze Pellengahr C

Reference 1. Curl WW, Krome J, Gordon ES, et al. Cartilage injuries: a review of 31,516 knee arthroscopies. Arthroscopy. 1997;13:456–460. 2. Widuchowski W, Widuchowski J, Trzaska T. Articular cartilage defects: study of 25,124 knee arthroscopies. Knee. 2007;14:177–182. 3. Han B, Woodell-May J, Ponticiello M, et al. The effect of thrombin activation of platelet-rich plasma on demineralized bone matrix osteoinductivity. J Bone Joint Surg Am. 2009;91:1459Y70 4. Landesberg R, Roy M, Glickman RS. Quantification of growth factor levels using a simplified method of

Reference 1. Aglietti P, Buzzi R, D’Andria S, et al. Patellofemoral problems after intraarticular anterior cruciate ligament reconstruction. ClinOrthop.1993;288:195–204. 2. Anderson K, Seneviratne A, Izawa K, et al. Augmentation of tendon healing in an intraarticular bone tunnel with use of a bone growth factor. Am J Sports Med. 2001;29:689–698. 3. Woo SL-Y, Suh J-K, Parsons IM, et al. Biologic intervention in ligament healing Sports. Med Arthrosc Rev.1998;6:74–82. 4. Cervellin M, de Girolamo L, Bait C, Denti M, Volpi P. Autologous platelet-rich plasma gel to