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Quercetin is a natural polyphenol with proven health beneficial activities. In this study 15 new quercetin derivatives were prepared with the aim to enhance their bioavailability. Modification of their physicochemical properties could herewith improve the action in cells. The prepared compounds were tested for their antioxidant and cytotoxic activity. The ability to scavenge free radicals as well as ferric reducing antioxidant power of the new derivatives was not better than that of unmodified quercetin. But for acetylated esters a better cytotoxic activity was found on human cervical cancer cells HeLa than for the initial molecule. The best effect revealed chloronaphtoquinone quercetin (IC50=13.2 μM). For this compound comparable cytotoxic action on non-cancer murine fibroblast cells was detected (IC50=16.5 μM). The obtained results indicate that appropriate lipophilization of the quercetin molecule could improve its cytotoxic action in cells, probably due to its enhanced bioavailability

alkaloids isolated from Stephania rotunda in vitro, cytotoxic activity of cepharanthine. Phytother Res 23 (4): 587–590. Danihelova M, Veverka M, Sturdik E, Jantova S. (2013). Antioxidant action and cytotoxicity on HeLa and NIH-3T3 cells of new quercetin derivatives. Inter-discip Toxicol 6 (4): 209–216. Furr M, Mahlberg P G. (1981). Histochemical analyses of laticifers and glandular trichomes in Cannabis sativa . J Nat Prod 44 (2): 153–159. Grzybek J, Zgorniak-Nowosielska I, Kasprowicz A, Zawilinska B, Kohlmunzer S. (1994). Antitumor activity of a fungal glucan

- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells. Toxicol Lett 2008, 179, 130-139. 19. Hussain S.M, Hess K.L, Gearhart J.M, Geiss K.T, Schlager J.J.: In vitro toxicity of nanoparticles in BRL 3A rat liver cells. Toxicol In Vitro 2005, 19, 975-983. 20. Karlsson H.L, Cronholm P, Hedberg Y, Tornberg M, De Battice L, Svedhem S, Wallinder I.O.: Cell membrane damage and protein interaction induced by copper containing nanoparticles - importance of the metal release process. Toxicology 2013, 313, 59-69. 21. Kim Y.S, Kim J.S, Cho H.S, Rha D

interaction with the nuclear factor of interleukin 6. J Biol Chem. 2002; 277: 11802-10. 17. Yu FX, Zhang HL, Chen GW, Wang QP, Shi YZ, Liu Y, et al. Screen of inflammatory genes regulated by heat shock factor 1 and corroboration with SOCS3 gene. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2006; 31: 167-73. 18. Sugisawa N, Matsuoka M, Okuno T, Igisu H. Suppression of cadmium-induced JNK/p38 activation and HSP70 family gene expression by LL-Z1640-2 in NIH3T3 cells. Toxicol Appl Pharmacol. 2004; 196: 206-14.

.3109/03602538508991430 PMid:3905315 9. Russell DH , Snyder SH.Amine synthesis in regenerating rat liver: Extremely rapid turnover of ornithine decarboxylase. Mol Pharmacol 1969; 5: 253-262 PMid:5783961 10. Shayovits A, Bachrach U. Ornithine decarboxylase: an indicator for growth of NIH 3T3 fibroblasts and their c- Ha-ras transformants. Biochim Biophys Acta 1995; 1267: 107-14 11. Pegg AE. Recent advances in the biochemistry of polyamines in eukaryotes. Biochem J 1986; 234: 249-62 PMid:3087344 PMCid:1146560 12. Pegg AE, Shantz LM, Coleman CS

., 132 , 60–66. Hitomi, M., Stacey, D. W. (1999). Cellular ras and cyclin D1 are required during different cell cycle periods in cycling NIH 3T3 cells. Mol. Cell. Biol. , 19 (7), 4623–4632. Hundemer, U., Klein, D. Hose, Raab, M. S., Cremer, F. W., Jauch, A., Benner, A., Heiss, C., Moos, M., Ho, A. D., Goldschmidt, H. (2007). Lack of CD56 expression on myeloma cells is not a marker for poor prognosis in patients treated by high-dose chemotherapy and is associated with translocation t(11;14). Bone Marrow Transplant. , 40 , 1033–1037. Lokhorst, H. (2002). Clinical

of a carbonaceous bottling plant effluent on albino mice sperm morphology and testes histopathology. Nature Science, 10 :154-160. Alabi, O.A., Bakare, A.A., Filippin-Monteiro, F.B., Sierra, J.A., Creczynski-Pasa, T.B., 2013. Electronic waste leachate-mediated DNA fragmentation and cell death by apoptosis in mouse fibroblast (NIH/3T3) cell line. Ecotoxicology and Environmental Safety, 94 :87-93. Alabi, O.A., Bakare, A.A., 2015. Cytogenotoxic Effects and Reproductive Abnormalities Induced by e-waste Contaminated Underground Water in Mice. Cytologia, 79 (3

T1a,bN0 breast cancer. Int J Radiat Oncol Biol Phys 2010; 77: 1296-302. 28. Pietras RJ, Poen JC, Gallardo D, Wongvipat PN, Lee HJ, Slamon DJ. Monoclonal antibody to HER-2/neureceptor modulates repair of radiationinduced DNA damage and enhances radiosensitivity of human breast cancer cells overexpressing this oncogene. Cancer Res 1999; 59: 1347-55. 29. Pirollo KF, Tong YA, Villegas Z, Chen Y, Chang EH. Oncogene- transformed NIH 3T3 cells display radiation resistance levels indicative of a signal transduction pathway leading to the radiation-resistant phenotype

polyurethane induces antimicrobial activity in central venous catheters”, Infection, Vol. 27, 16-23, 1999. DOI:10.1007/BF02561612 [9] S. Gurunathana, K.J. Leeb, K. Kalishwaralala, S. Sheikpranbabua, R. Vaidyanathan, and S.H. Eom, “Antiangiogenic properties of silver nanoparticles”, Biomaterials, Vol. 30, 6341-6350, 2009. DOI: 10.1016/j.biomaterials.2009.08.008. [10] Y.H. Hsin, C.F. Chen, S. Huang, T.S. Shih, P.S.Lai, and P.J. Chueh, “The apoptotic effect of nanosilver is mediated by a ROS- and JNK-dependent mechanism involving the mitochondrial pathway in NIH3T3 cells

, J. L., McGarrity, L. J., and Beland, F. A. (2009). Interference of cell cycle progression by zidovudine and lamivudine in NIH 3T3 cells, Mutagenesis, 24 (2); 133-141. Franchi, L. P., Pentiado, N. H. G. R., Silva, R. N., Guimarães, N. N., Jesuino, R. S. A., de Andrade, H. H. R., Lehman, M., and Cunha, K. S. (2009). Mutagenic and recombinagenic effects of lamivudine and stavudine antiretrovirals in somatic cells of Drosophila melanogaster , Food and Chemical Toxicology, 47 ; 578-582. Giri, S., Prasad, S.B., Giri, A., and Sharma, G.D. (2002). Genotoxic effects of