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Novel Ret Mutations in Macedonian Patients with Medullary Thyroid Carcinoma: Genotype-Phenotype Correlations/ Нови Ret-Мутации Кај Македонски Пациенти Со Медуларен Карцином На Тироидната Жлезда: Генотипско-Фенотипски Корелации

References 1. Jandrichova S, Vcelak J, Vlcek P, Neradilova M, Nemec J, Bendlova B. Screening of six risk exons of the ret proto-oncogene in families with medullary thyroid carcinoma in the Czech Republic. Journal of Endocrinology. 2004; 183: 257-265. 2. National Cancer Institute. MedullaryThyroid Cancer. available at: http://www.cancer.gov/cancertopics/pdq/genetics/medullarythyroid/HealthProfessional/page2/print 3. Eng Charis. Ret proto-oncogene in the development of human cancer. J Clin Oncol. 1999; 17(1): 380

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Recommedition for Apllication and Determination Tumor Markers of Neuroendocrine System

Preporuke Za Primenu I Određivanje Tumorskih Markera Kod Neoplazmi Neuroendokrinog Sistema

Neuroendokrini tumori vode poreklo iz neuroendokrinih ćelija, koji pod uslovima specifične stimulacije sekretuju hormone, regulišući niz različitih funkcija u organizmu. U radu je opisana grupa neuroendokrinih tumora koja se sastoji od: karcinoida endokrinih tumora pankreasa, neuroblastoma, medularnog karcinoma tiroidee i feohromocitoma. Biće diskutovani tumori koji potiču iz endokrinih žlezda, kao i oni koji vode poreklo iz takozvanog »difuznog« neuroendokrinog ćelijskog sistema gastrointestinalnog trakta. Radi se o najvećem endokrinom organu u organizmu. Oko 50 različitih neuroendokrinih ćelijskih tipova gastrointestinalnog trakta je indentifikovano. Važan dijagnostički segment u tretmanu ovih tumora, je određivanje biogenih amina i peptida, čija je aktivnost izmenjena kod pojave neoplazmi. Širok je spektar kliničkih simptoma kod pojave ove vrste tumora, a svi su posledica sposobnosti tumora da sekretuju povećane količine peptinih hormona i biogenih amina. Glavni ciljevi ovog teksta su procena važnosti ove grupe tumorskih markera, kao i predlozi za njihovo koriŠćenje u našim uslovima.

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Importance of Hormones and Proteins Determination in the Material Obtained by Fine-Needle Aspiration

-51. Capelli C, Rotondi M, Pirola I, DE Martino E, Leporati P, Magri F, Agabiti Rosei E, Chiovato L, Castellano M. Prevalence of parathyroid cysts by neck ultrasound scan in unselected patients J Endocrin Invest 2009; 32, 4: 357-9. Kagel RF: Multiple endocrine neoplasia. In: Wilson JD, et al. William s textbook of endocrinology. IX ed, New York Saunders, 1998; 138: 1627-49. Chang TC, Wu SL, Hsiao YL. Medullary thyroid carcinoma: pitfalls in diagnosis by fine needle aspiration cytology and relationship of cytomorphology to

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Urinary Cystatin C as a Marker of Tubular Dysfunction

. J Cell Physiol 1997; 173 : 423-32. Grubb A, Lofberg H. Human gamma-trace, a basic microprotein: amino acid sequence and presence in the adenohypophysis. Proc Natl Acad Sci USA 1982; 79 : 3024-7. Lofberg H, Grubb A, Davidsson L, Kjellander B, Stromblad LG, Tibblin S, et al. Occurrence of gamma-trace in the calcitonin-producing C-cells of simian thyroid gland and human medullary thyroid carcinoma. Acta Endocrinol (Copenh) 1983; 104 : 69-76. Lofberg H, Nilsson KE, Stromblad LG

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Pheochromocytoma, diagnosis and treatment: Review of the literature

, Mino J, Mitchell J, Hamrahian A, Siperstein A, Berber E. Predictors of recurrence in pheochromocytoma. Surgery 156, 1523–1528, 2014. Prokopakis E, Doulaptsi M, Kaprana A, Velegrakis S, Vlastos Y, Velegrakis G. Treating medullary thyroid carcinoma in a tertiary center. Current trends and review of the literature. Hippokratia 18, 130–134, 2014. Renard J, Clerici T, Licker M, Triponez F. Pheochromocytoma and abdominal paraganglioma. J Visc Surg 148, e409–e416, 2011. Reynolds RM, Browning GG, Nawroz I, Campbell IW. Von Recklinghausen’s neurofibromatosis

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Variants in mitochondrial tRNA gene may not be associated with thyroid carcinoma

Introduction With an incidence of 2.0%, thyroid carcinoma is the most common form of endocrine system malignancy [ 1 , 2 ]. Thyroid carcinomas are histologically classified as papillary thyroid carcinoma (PTC), follicular thyroid carcinoma (FTC), anaplastic thyroid carcinoma (ATC) and medullary thyroid carcinoma (MTC), accounting for approximately 80.0, 15.0, 2.0 and 4.0% of all thyroid malignancies, respectively [ 3 ]. Decreased survival in patients with oncocytic carcinomas may be due to reduced competence in iodine uptake by the tumor cells, resulting in

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The Role of Genetics in Sporadic GEP-NETs: A Comprehensive Review of the Literature

Nov 3;281(44):33577-87 10.1074/jbc.M605604200 Knowles PP Murray-Rust J Kjaer S Structure and chemical inhibition of the RET tyrosine kinase domain J Biol Chem. 2006 Nov 3 281 44 33577 87 [25] Xiao-Ping Qi,1,* Ju-Ming Ma,1 Zhen-Fang Du et al. RET Germline Mutations Identified by Exome Sequencing in a Chinese Multiple Endocrine Neoplasia Type 2A/Familial Medullary Thyroid Carcinoma Family. PLoS One. 2011; 6(5): e20353. 10.1371/journal.pone.0020353 Xiao-Ping Qi,1,* Ju-Ming Ma,1 Zhen-Fang Du RET Germline Mutations Identified by Exome Sequencing

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Comparison between whole-body MRI and Fluorine-18-Fluorodeoxyglucose PET or PET/CT in oncology: a systematic review

. Imaging medullary thyroid carcinoma with persistent elevated calcitonin levels. J Clin Endocrinol Metab 2007; 92: 4185-90. 60. Takano A, Oriuchi N, Tsushima Y, Taketomi-Takahashi A, Nakajima T, Arisaka Y, et al. Detection of metastatic lesions from malignant pheochromocytoma and paraganglioma with diffusion-weighted magnetic resonance imaging: comparison with 18F-FDG positron emission tomography and 123I-MIBG scintigraphy. Ann Nucl Med 2008; 22: 395-401. 61. Plathow C, Walz M, Lichy MP, Aschoff P, Pfannenberg C, Bock H, et al

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Genome Instability and Bleomycin Sensitivity Test

, Scarfí MR, Zeni O, Temperani P, Emilia G, Sansoni P, Lioi MB, Troiano L, Agnesini C, Salvioli S, Cossariza A. Genomic instability and aging. Studies in centenarians (successful aging) and in patients with Down's syndrome (accelerated aging). Ann NY Acad Sci 1992;663:4-16. Cherry LM, Hsu TC. Bleomycin-induced chromosome damage in lymphocytes of medullary thyroid carcinoma patients and their family members. Anticancer Res 1983;3:367-72. Schantz SP, Spitz MR, Hsu TC. Mutagen sensitivity in patients with head and neck

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The role of glucagon-like peptide-1 receptor agonists in the treatment of type 2 diabetes

require reconstitution. May be kept at room temperature not exceeding 86°F up to 14 days Unavailable U.S. Boxed Warning: None Injection site reaction: 4% Nausea: 25% URTI: Not reported B3 Based on European and Australian package inserts, there is no adequate data from use in pregnancy. Not recommended in severe renal impairment (CrCl < 30 mL/min) or end-stage renal disease. MTC: medullary thyroid carcinoma; MEN2: multiple endocrine neoplasia type 2; URTI: upper respiratory tract infection. Evidence for use of GLP-1 agonists with oral

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