Despina V. Pupaki, Dessislava Ankova, Veselin P. Vasilev and Pavel I. Rashev
1. Sternlicht M. The cues that regulate ductal branching morphogenesis. Breast Cancer Res. 2006;8(1):201.
2. Sinowatz S, Wrobel K, Etreby MF El, Sinowatz F. On the ultrastructure of the canine mammarygland during pregnancy and lactation. J Anat. 1980;131(2):321-32.
3. Oakes S, Hilton H, Ormandy C. The alveolar switch: coordinating the proliferative cues and cell fate decisions that drive the formation of lobuloalveoli from ductal epithelium. Breast Cancer Res. 2006;8(2):207.
4. Wiseman B, Werb Z. Stromal effects on mammary
1. Adriance, M. C., Inman, J. L., Petersen, O. W., Bissell, M. J., 2005: Myoepithelial cells: good fences make good neighbors. Breast Cancer Res. , 7, 190—197.
2. Alkafafy, M., Rashedb, R., Helalc, A., 2011: Immunohistochemical studies on the bovine lactating mammarygland ( Bos taurus ). Acta Histochemica , 114, 87—89.
3. Destexhe, E., Lespagnard, L., Degeyter, M., Heymann, R., Coignoul, F., 1993: Immunohistochemical identification of myoepithelial, epithelial, and connective tissue cells in canine mammary tumors. Vet. Pathol
Viktória Kissová, Zuzana Ševčíková, Viera Revajová, Róbert Herich and Mikuláš Levkut
tumor. Arq Bras Med Vet Zootec 2010, 62, 1348–1351.
12. Li H., Fan X., Houghton J.M.: Tumor microenvironment: the role of the tumor stroma in cancer. J Cell Biochem 2007, 101, 805–815.
13. Maffini M.V., Soto A.M., Calabro J.M., Ucci A.A., Sonnenschein C.: The stroma as a crucial target in rat mammarygland carcinogenesis. J Cell Sci 2004, 15, 1495–1502.
14. Molin D., Edström A., Glimelius I., Glimelius B., Nilsson G., Sundström C., Enblad G.: Mast cell infiltration correlates with poor prognosis in Hodgkin’s lymphoma. Br J Haematol 2002, 119, 122
Katarzyna Łosiewicz, Małgorzata Chmielewska-Krzesińska, Piotr Socha, Anna Jakimiuk and Krzysztof Wąsowicz
The expression of miRNA-21, miRNA-10b, and miRNA-34a in malignant and benign tumours and non-neoplastic lesions in canine mammary gland, using real-time PCR with TaqMan probes was determined. The expression in normal tissues was compared to neoplastic and non-neoplastic lesions using one-way ANOVA test. Significant changes in miRNA expression in neoplastic tissues, as compared to normal ones, were demonstrated. In all neoplastic tissues, the miRNA-21 expression increased while in non-neoplastic lesions slightly decreased in comparison to normal ones. MiRNA-10b expression in malignant and benign tumours increased in comparison to normal tissues and non-neoplastic lesions. MiRNA-34a expression profile in neoplastic and non-neoplastic tissues differed from other examined miRNAs (miRNA-21 and miRNA-10b). In all samples miRNA-34a expression level decreased in comparison to normal tissues.
1. Vail, D. M., Mac Ewen, E.G. (2000). Spontaneously occurring tumors of companion animals as models for human cancer. Cancer Invest. 18(8): 781-792. https://doi.org/10.3109/07357900009012210 PMid:11107448
2. Misdorp, W. (2002). Tumors of the mammarygland. In: Meuten DJ. (Ed.), Tumors in domestic animals (pp. 575-606). 4th ed. Ames, USA: Iowa State Press. https://doi.org/10.1002/9780470376928.ch12
3. Schmidt, R. E., Langham, R. F. (1967). A survey of feline neoplasms. J Am Vet Med Assoc. 151, 1325-1328.
4. Hayden, D. W
Kibrom M. Alula, James H. Resau and Osman V. Patel
., 2004 ; Shikone et al., 1997 ). It is well established that there is an extensive turnover of the secretory cells in the mammarygland during lactogenesis and the milk output is directly correlated with the number of functional cells ( Capuco and Ellis, 2013 ; Capuco et al., 2001 ; Knight and Peaker, 1982a ; Li et al., 1999 ). Consequently, an imbalance in the cell turnover rate in the mammarygland during a lactation cycle directly impacts milk production and overall yield ( Capuco and Ellis, 2013 ; Capuco et al., 2001 ; Knight and Peaker, 1982a ; Li et al
Gustavo A. Roa López, Jhon Jairo Suárez, Paola Barato and Noel Verján García
-H reading frame 1 (BHRF1) and LMP1 gene transcripts by RT-PCR in multiple mainly oral canine tumours ( 4 ), whereas other researchers did not detect EBV Bam HI-A leftward fragment 5 (BALF 5), HPV16, MMTV, or human polyomavirus BK in canine mammary tumours by qPCR ( 30 ). To contribute to the molecular epidemiology of mammary tumours in dogs, the aim of this study was to describe the histopathological findings in the tumourous mammarygland of dogs and to evaluate the presence of EBV gene sequences by nested-PCR.
Material and Methods
Canine tissue samples . A total
Hoda Javaheri Barfourooshi, Armin Towhidi, Hassan Sadeghipanah, Mahdi Zhandi, Saeed Zeinoaldini, Essa Dirandeh and Robert M. Akers
Abramoff M.D., Magelhaes P.J., Ram S.J. (2004). Image Processing with ImageJ. Bioph. Inter., 11: 36–42.
Abu-Ghazaleh A.A., Schingoethe D.J., Hippen A.R., Kalscheur K.F., Whitlock L.A. (2002). Fatty acid profiles of milk and rumen digesta from cows fed fish oil, extruded soybeans or their blend. J. Dairy Sci., 85: 2266–2276.
Akers R.M. (2002). Lactation and the mammarygland. Iowa, USA, Wiley-Blackwell, 1st ed., 278 pp.
Akers R.M., Nickerson S.C. (1983). Effect of prepartum blockade of microtubule formation on milk production and
associated with the incidence rate of clinical mastitis. Journal of Dairy Science , (82), 1643-1654.
Butler, J. E. (1994) Passive immunity and immunoglobulin diversity. Indigenous Antimicrobial Agents of Milk - Recent Developments. IDF Special Issue No. 9404 (4), 14-50.
Craven, N., & Williams, M. R. (1985). Defenses of the bovine mammarygland against infection and prospects for their enhancements. Veterinary Immunology and Immunopathology , 10, 71-127.
Doymaz, M. Z., Sordillo, L. M., Oliver
Banghart L. R., Clayton C. W., Velarde J., Korobko I. V., Ogg S. L., Jack L. J. W., Vakharia V. N., Mather I. H., Butyrophilin is expressed in mammary epithelial cells from a single-sized messenger RNA as a type I membrane glycoprotein. J. Biol. Chem., 1998, 273, 4171-4179.
Bansal M. P., Medina D., Expression of fatty acid-binding proteins in the developing mouse mammary-gland. Biochem. Biophys. Res. Commun., 1993, 191, 61-69.
Bargmann W., Knoop A., Morphology of lactation: light and electro-microscopic studies on the