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The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin

lipid metabolism in the perfused rat liver. J. Clin. Invest., 64, 182, 1979. 12. Lebrecht D., et al.: Time-dependent and tissue-specific accumulation of mtDNA and respiratory chain defects in chronic doxorubicin cardiomyopathy. Circulation., 108, 2423, 2003. 13. Lombardi A, et al.: 3,5-Diiodo-L-thyronine regulates glucose-6- phosphate dehydrogenase activity in the rat. Endocrinology., 141, 1729, 2000. 14. Martini G., Ursini M. V.: A new lease of life for an old enzyme. Bioessays, 18, 631, 1996. 15. Merten

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Evaluation of Lipid Metabolism and Nutritional Status in Male Goalball Players

International Classification of Functioning, Disability, and Health framework. Ophthalmic Epidemiol , 2010; 6: 400-410 Jóźwiak J. Evaluation of lipid metabolism, nutritional status and health awareness in the population included in care by family doctors. StatSoft Polska ; 2008 Kay S, Fiatarone Singh M. The influence of physical activity on abdominal fat: a systematic review of the literature. Obes. Rev , 2006; 7: 183-200 Komal W, Jaipanesh K, Seemal M. Association of leisure time physical activity, watching television, obesity & lipid profile among

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The effect of one-electron reduced drugs on hepatic aconitase activity and triglycerides level

selective cancer therapy- eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res., 59, 5863, 1999. 5. Czuba B. et al.: The effect of thyroxin on hepatic redox equilibrium and lipid metabolism in rats treated with doxorubicin. Curr Issues Pharm Med Sci., 27(4), 220, 2014. 6. Dorie M.J., Brown J.M.: Modification of the antitumor activity of chemotherapeutic drugs by the hypoxic cytotoxic agent tirapazamine. Cancer Chemotherapy and Pharmacology., 39, 361, 1997. 7. Dudka J. et al.: Activity of NADPH-cytochrome P-450

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Analysis of the PPARD gene expression level changes in football players in response to the training cycle

-known causative agents of alteration in PPARD expression level in skeletal muscle [ 2 , 12 , 18 ]. Analysis of the mRNA expression in skeletal muscles obtained from males proved that during recovery from endurance exercise (in the first 3 hours) it can be observed in transient elevated PPARD expression level (2.6±0.6-fold) [ 19 ]. Therefore, we performed this study to evaluate if there is any relationship between training-induced changes in PPARD gene expression level and lipid metabolism parameters. Material and methods The study was approved by the Medical

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Amisulpride - An Athypical Antipsychotic?

Abstract

Aim: the purpose of the present study was to determine the effects of amisulpride at different doses on body weight, glucidic and lipidic metabolism.

Material and method: Thirty-six white Wistar rats were treated daily for 9 weeks with amisulpride 1mg/kg and 10mg/kg body weight. Another group received distilled water and served as control group. At the end of the treatment period blood samples were collected and the follow biochemical parameters were determined: serum cholesterol, triglycerides, blood glucose, GOT, GPT. Body weight gain was also assessed weekly.

Results: After treatment with amisulpride in doses of 1mg/kg and 10 mg/kg for a period of nine weeks, weight gains were recorded for both groups compared with the initial weight and the control group. Blood glucose concentrations in the group treated with 1 mg amisulpride/kg body weight were significantly increased (p<0.05 vs control group), but in the group treated with 10 mg/kg body weight glucose levels were not statistically significant increased compared to controls. Other biochemical parameters (cholesterol, triglycerides, GOT, GPT) showed no statistically significant differences compared to control group.

Conclusions: amisulpride administered over a period of 9 weeks, in doses of 1mg/kg and 10mg/kg showed a slight increase of body weight regardless of gender, increased blood glucose only when was administered in the low dose, and does not affect lipid metabolism, even though decreased cholesterol and triglycerides levels. This results highlight a real benefit of treatment with amisulpride, comparatively with other athypical antipsychotics.

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Molecular Pathogenesis of Liver Steatosis Induced by Hepatitis C Virus

the cannabinoid receptor 1. PLoS One 2010;5. pii: e12841. 33. Miyoshi H, Moriya K, Tsutsumi T, Shinzawa S, Fujie H, Shintani Y, et al. Pathogenesis of lipid metabolism disorder in hepatitis C: polyunsaturated fatty acids counteract lipid alterations induced by the core protein. J Hepatol 2011;54:432-438. 34. Mancone C, Montaldo C, Santangelo L, Di Giacomo C, Costa V, Amicone L, et al. Ferritin heavy chain is the host factor responsible for HCV-induced inhibition of apoB-100 production and is required for efficient viral infection. J

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Condition of sows during reproductive activity depending on lipid metabolism gene (DGAT1) polymorphism

Abstract

Mutations at gene loci associated with body lipid metabolism may affect not only carcass and meat quality traits in young animals but also the production results of mother sows. The objective of the study was to determine the effect of mutations in the DGAT1 gene, found in Polish populations of maternal breeds, on condition of gilts and later on condition and reproductive performance of sows during three reproductive cycles. The study involved 118 gilts of maternal breeds (Polish Large White (PLW ) and Polish Landrace (PL)). Gilts and subsequently sows were monitored for body weight (BW) and P2 backfat thickness over three reproductive cycles and their litters were analysed for the number and body weight of the piglets. A total of 354 litters of pigs were evaluated. In the analysed pig populations, a single mutation (A/G) in the DGAT1 gene (rs45434075) had a significant effect on deposition of subcutaneous fat only in the PLW gilts (P2G, AA,AG<GG P≤0.05 and P2F r=214 P≤0.01). As regards the G/A 3’UTR polymorphism of the DGAT1 gene (rs342152658), this mutation is negatively correlated only in the PL sows with fatness during their reproductive life and with BW of the piglets reared to 21 d of age. Sows of the DGAT1GG 3’UTR genotype had significantly lower P2F backfat thickness (P≤0.05) and, during a 21-d lactation, reared lighter piglets (P≤0.01) compared to sows of the same breed with the DGAT1AG 3’UTR genotype. The analysed traits were also affected by the interaction between mutations in the DGAT1 gene of the sows of maternal breeds (DGAT1/DGAT1 3’UTR). Sows of the DGAT1GG/GG genotype were characterised by the highest backfat thickness on selection day, and during three reproductive cycles they reared significantly more piglets compared to sows of the DGAT1AA/AG genotype. Heterozygous sows (AG/AG) reared significantly heavier piglets than sows of the AA/GG and AG/GG genotypes (P≤0.05).

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The LRP1 gene polymorphism is associated with increased risk of metabolic syndrome prevalence in the Serbian population

markers for adipocyte differentiation and the maintenance of lipid levels in mature adipocytes, and has a key role in lipid metabolism [ 14 , 15 ]. Liu et al . [ 16 ] found that LRP1, which is critical in lipid metabolism, also regulates food intake and energy homeostasis in adult central nervous system. The investigation of Niemeier et al . [ 17 ] showed that among the low-density lipoprotein receptor (LDLR) family in human osteoblasts, LRP1 plays a predominant role in vitamin K1 uptake through chylomicron remnants endocytosis. Association between LRP1 and lung

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Biochemical aspects of KB-28 compound on physically loaded study subjects

-carnitine L-tartrate on Lipid Metabolism during Aerobic Exercise. J Kerman U Med Sci. 2010;17(2):113-20 22. Ji LL, Zhang Y. Antioxidant and anti-inflammatory effects of exercise: role of redox signaling. Free Rad Res. 2013;48(1):3-11. http://doi.org/10.3109/10715762.2013.844341 23. Pingitore A, Lima G, Mastorci F, Quinones A, Iervasi G, Vassalle C. Exercise and oxidative stress: Potential effects of antioxidant dietary strategies in sports. Nutrition . 2015;31(7-8):916-22. http://doi.org/10.1016/j.nut.2015.02.005

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Antidotal activity of Averrhoa carambola (Star fruit) on fluoride induced toxicity in rats

ABSTRACT

Consumption of fluoride leads to several physiological disturbances in carbohydrate, lipid and antioxidant metabolisms. Averrhoa carambola L. fruit (Star fruit) is a commonly consumed fruit in tropical countries and is an ingredient in folklore medicines. As the fruits have high polyphenolic and antioxidant contents, the present study was undertaken to investigate the potential of star fruit as a dietary supplement in attenuating the fluoride induced hyperglycemia, hypercholesterolemia and oxidative stress in laboratory rats. A four-week exposure to fluoride caused sustained hyperglycemia, hyperlipidemia and oxidative stress and, when the diet was supplemented with star fruit powder, carbohydrate, lipid and antioxidant profiles were restored significantly. It is surmised that the antihyperglycemic, antihypercholesterolemic and antioxidant activities of star fruit in fluoride exposed rats could be due to the presence of polyphenols, flavonoids, saponins, phytosterols, ascorbic acid and fibers in the fruit, which are all well known regulators of carbohydrate, lipid and antioxidant metabolisms. These findings suggest that star fruit can be used as a dietary supplement in fluoride endemic regions to contain fluoride induced hyperglycemia, hyperlipidemia and oxidative stress

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