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Ki-67 Expression In Hepatocellular Carcinoma Developed On A Liver Cirrhosis

V, ALLGAIER HP, KOELBLE K.: Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival. Hepatology 2003; 38: 470-480 4. JUN CUI, BAO-WEI DONG, PING LIANG, XIAO-LING YU, DE-JIANG YU: Effect of c-myc, Ki-67, MMP-2 and VEGF expression on prognosis of hepatocellular carcinomapatients undergoing tumor resection, World J Gastroenterol 2004;10(10):1533-1536 5. D’ERRICO A, GRIGIONI WF, FIORENTINO M, BACCARINI P, GRAZI GL, MANCINI AM: Overexpression of p53 protein and Ki67

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The proliferation marker Ki67, but not neuroendocrine expression, is an independent factor in the prediction of prognosis of primary prostate cancer patients

those markers, has been associated with disease progression 4 or poor survival in prostate cancer 5 , but up to now its prognostic value has not been clarified because of controversial results 6 ; 7 , 8 . However, Epstein et al. 9 have recently suggested using neuroendocrine markers to better characterize and classify NED in prostate cancer. They also outlined Ki67 ranges in those tumors, which usually have a high proliferative index. 4 , 9 - 13 Ki67 is a well-known marker in oncology for defining tumor proliferation. Expression of Ki67 detection by

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Immunoexpression of Ki67 and p53 in the Dental Follicles of Impacted Teeth

, Inderpreet Kaur, and Shalabh Srivastava, Analysis of the immunoexpression of Ki-67 and Bcl-2 in the pericoronal tissues of impacted teeth, dentigeous cysts and gingiva using software image analysis, Dent Res J (Isfahan), 2013; 10:31-37. 6. Ozveren A, Tuskan C, Yaltirik M, Et all. Expresion or the tumor suppresor gene p53 in odontogenic cyst. Turk J Med Sci, 2003; 33:243-247. 7. Maryam Seyedmajidi, Shima Nafarzadeh, Sepideh Siadati, Shahryar Shafaee, Ali Bijani, Nazanin Kehmiri, p53 and PCNA expressin in Keratocystic odontogenic tumors compared with Selected

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Prognostic Value of ALDH1, EZH2 and Ki-67 in Astrocytic Gliomas

. Cancer. 2015;121:1499-507. 17. Kee N, Sivalingam S, Boonstra R, Wojtowicz JM. The utility of Ki-67 and BrdU as proliferative markers of adult neurogenesis. J Neurosci Methods. 2002;115:97-105. 18. Yuan Y, Xiang W, Yanhui L, Ruofei L, Shuang L, Yingjun F, Qiao Z, Yanwu Y, Qing M. Ki-67 overexpression in WHO grade II gliomas is associated with poor postoperative seizure control. Seizure. 2013;22:877-81. 19. Wu Z, Wang Q, Wang L, Li G, Liu H, Fan F, Li Z, Li Y, Tu Y. Combined aberrant expression of Bmi1 and EZH2 is predictive of poor prognosis in glioma

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The predictive role of Ki-67 protein in determining the aggressiveness of primary malignant bone tumors. A retrospective study

References 1. Von Eisenhart-Rothe R, Toepfer A, Salzmann M, Schauwecker J, Gollwitzer H, Rechl H. Primary malignant bone tumors. Orthopade. 2011 Dec; 40(12):1121-42. 2. Majid C, Keith H, Lee J. Primary malignant tumours of the bone. Surgery. 2009 February; 27(2):80-85. 3. Bruno S, Darzynkiewicz Z. Cell cycle dependent expression and stability of the nuclear protein detected by Ki-67 antibody in HL-60 cells. Cell Proliferation. 1992 January; 25(1):31–40. 4. Hernández-Rodríguez NA, Correa E, Sotelo R, Contreras-Paredes A, Gomez-Ruiz C, Green

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Correlation of diffusion MRI with the Ki-67 index in non-small cell lung cancer

: applications and challenges in oncology. AJR Am J Roentgenol 2007; 188: 1622-35. 9. Padhani AR, Liu G, Koh DM, Chenevert TL, Thoeny HC, Takahara T, et al. Diffusion-weighted magnetic resonance imaging as a cancer biomarker: consensus and recommendations. Neoplasia 2009; 11: 102-25. 10. Scholzen T, Gerdes J. The Ki-67 protein: from the known and the unknown. J Cell Physiol 2000; 182: 311-22. 11. Raĭkhlin NT, Bukaeva IA, Smirnova EA, Gurevich LE, Delektorskaia VV, Polotskiĭ BE, et al. Significance of the expression of nucleolar argyrophilic

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Expression of p16 (INK4a), cytokeratin 19, and Ki-67 in canine laryngeal squamous cell carcinoma

References 1. Agoff S.N., Lin P., Morihara J., Mao C., Kiviat N.B., Koutsky L.A.: p16INK4a expression correlates with degree of cervical neoplasia: A comparison with Ki-67 expression and detection of high-risk HPV types. Mod Pathol 2003, 16 , 665-673. 2. Barnard N.J., Hall P.A., Lemoine N.R., Kadar N.: Proliferative index in breast carcinoma determined in situ by Ki67 immunostaining and its relationship to clinical and pathological variables. J Pathol 1987, 152 , 287-295. 3. Beaumont P.R., O’Brien J

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Telomerase Activity and MDS/EVI Gene Fusion in Myelodysplastic Syndrome. Correlation to the Immunohistochemical Expression of Ki-67, Bcl-2 and p53 in Bone Marrow Biopsy Samples

Telomerase Activity and MDS/EVI Gene Fusion in Myelodysplastic Syndrome. Correlation to the Immunohistochemical Expression of Ki-67, Bcl-2 and p53 in Bone Marrow Biopsy Samples

Background. Myelodysplastic syndrome (MDS) as a complex disorder comprised of 7 entities may arise as a primary disorder, or in a setting of an underlying disease, or as therapy related (secondary MDS). Some cases show MDS/EVI1 gene fusion, and some studies have pinpointed the association between the high-risk MDS and increased telomerase activity.

Aim. To determine the frequency of MDS/EVI1 gene fusion in cases of primary MDS, and to evaluate the possibility for detection of increased telomerase activity in peripheral blood samples from patients with MDS.

Material and methods. We isolated DNA from 35 bone marrow biopsies, and measured the blood telomerase activity (RTA) in 21 of the patients. We performed immunostainigs for Ki-67, Bcl-2 and p53 on the biopsy samples in order to test the correlations to the RTA and MDS/EVI1 presence. MDS/EVI1 fusion was detected with touch-down-direct PCR, and RTA was measured using the "TeloTAGGG-PCR-ELISA-plus kit".

Results. We found MDS/EVI1 fusion in 17.39% of high-risk MDS cases (overall 11.43%). RTA was highly variable in the analyzed group, with 1,8 fold increase of the mean RTA compared to the controls. It was due to the significant RTA increase in high-risk MDS cases, compared to the low-risk cases (p<0.01).

Conclusion. RTA showed correlation to the immunohistochemical expression of Ki-67, and MDS/EVI1 fusion was correlated to the Bcl-2 expression.

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Preliminary Results on Clinicopathological and Immunohistochemical Features of Malignant Melanomas

. Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas. J Dermatol. 2008;35:215-221. 18. de Giorgi V, Gori A, Grazzini M, et al. Estrogens, estrogen receptors and melanoma. Expert Rev Anticancer Ther. 2011;11:739-747. 19. Vaisanen A, Kuvaja P, Kallioinen M, et al. A prognostic index in skin melanoma through the combination of matrix metalloproteinase-2, Ki67, and p53. Hum Pathol. 2011;42:1103-1111. 20. Helfrich I, Schadendorf D. Blood vessel maturation, vascular phenotype and angiogenic

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Novel Ret Mutations in Macedonian Patients with Medullary Thyroid Carcinoma: Genotype-Phenotype Correlations/ Нови Ret-Мутации Кај Македонски Пациенти Со Медуларен Карцином На Тироидната Жлезда: Генотипско-Фенотипски Корелации

G. et al. Medullary thyroid carcinoma. In: Pathology and genetics of tumors of endocrine system. World Health Organization Classification of Tumors, IARC, Lyon: IARC Press. 2001; 86-91. 7. Cobanoglu B, Ozercan M.R. Staining characteristics of BCL-2, BAX, p53, p21, Ki-67 andC-erbB2 in thyroid carcinomas. Erciyes Medical Journal 2007; 29 (3): 201-209. 8. Viale G, Roncalli M, Grimelius L, Graziani D, Wilander E, Johansson H, et al.: Prognostic value of bcl-2 immunoreactivity in medullary thyroid carcinoma. Hum Pathol. 1995; 26(9): 945

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