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Expression of genes encoding IGF1, IGF2, and IGFBPs in blood of obese adolescents with insulin resistance

N, Maitre M, Favereaux A, Vajkoczy P, Seno M, Bikfalvi A, Minchenko D, Minchenko O, Moenner M. High epiregulin expression in human U87 glioma cells relies on IRE1 alpha and promotes autocrine growth through EGF receptor. BMC Cancer 13, 597, 2013. Bass R, Eneli I. Severe childhood obesity: an under-recognised and growing health problem. Postgrad Med J 91, 639–645, 2015. Baxter RC. IGF binding proteins in cancer: mechanistic and clinical insights. Nat Rev Cancer 14, 329–341, 2014. Cai X, Wang L, Wang X, Hou F. Silence of IGFBP7 suppresses apoptosis

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Insulin-Like Growth Factors (Igfs) And Their Binding Proteins (Igfbps) As Biomarkers of Catabolism

References Mauras N, Haymond MW. Are the metabolic effects of GH and IGF-I separable? Growth Horm IGF Res 2005; 15: 19-27. O'Dell SD, Day IN. Insulin-like growth factor II (IGF-II). Int J Biochem Cell Biol 1998; 30: 767-71. Kim JJ, Accilli D. Signaling through IGF-I and insulin receptors: where is the specificity? Growth Horm IGF Res 2002; 12: 84-90. Kupfer SR, Underwood LE, Baxter RC, Clemmons DR. Enhancement of the anabolic effects of growth hormone

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The Role of Human Insulin Growth Factor (Igf) – Axis in Carcinogenesis

References [1] Alami N, Page V, Yu Q, Jerome L, Paterson J, Shiry L, Leyland-Jones B. Recombinant human insulin -like growth factor- binding protein 3 inhibits tumor growth and targets the Akt pathway in lung and colon cancer models. Growth Horm IGF Res 2008; 18: 487-496. [2] Akkiprik M, Hu L, Sahin A, Hao X, Zhang W. The subcellular localization of IGFBP5 affects its cell growth and migration functions in breast cancer. BMC Cancer 2009; 9: 103. doi:10.1186/1471-2407-9-103 [3] Attias-Geva ZA, Bentov I, Ludwig DL

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IGF1 Gene Polymorphism in Selected Species of the Canidae Family

References 1. Gray MM, Sutter NB, Ostrander EA, Wayne RK: The IGF1 small dog haplotype is derived from Middle Eastern grey wolves. BMC Biology 2010, 8:16. 2. Schwander JC, Hauri C, Zapf J, Froesch ER: Synthesis and secretion of insulin-like growth factor and its binding protein by the perfused rat liver: dependence on growth hormone status. Endocrinology 1983, 113:297-305. 3. Favier PR, Mol AJ, Kooistra SH, Rijnberk A: Large body size in the dog is associated with transient GH excess at a young age. J

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Evaluation of Polymorphism in IGF-I and IGFB-3 Genes and their Relationship tith Twinning Rate and Growth Traits in Markhoz Goats

References Adam C., Gadd T., Findlay P., Wathes D. (2000). IGF-Istimulation of luteinizing hormone secretion, IGF-binding proteins (IGFBPs) and expression of m RNAs for IGFs, IGFreceptors and IGFBPs in the ovine pituitary gland. J. Endocrinol., 166: 247-254. An X., Han P., Hou J., Zhao H., Yan Y., Ma T., Fang F., Meng F., Song Y., Wang J. (2013). Molecular cloning and characterization of KISS1 promoter and effect of KISS1 gene mutations on litter size in the goat. Genet. Mol. Res., 12: 4308-4316. An X.P., Hou J

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Genetic Differentiation of Common Fox Vulpes Vulpes (Linnaeus, 1758) on the Basis of the Insulin-Like Growth Factor 1 (Igf1), Myosin-Xv (Myo15a) and Paired Box Homeotic 3 (Pax3) Genes Fragments Polymorphism

-277. Morlais I., Poncon N., Simard F., Cohuet A., Fontenille D. (2004). Intraspecific nucleotide variation in Anopheles gambiae: new insights into the biology of malaria vectors. Am. J. Trop. Med. Hyg., 71: 795-802. MullenP.M., Berry P.D., HowardJ.D., Diskin G.M., Lynch O.C., Giblin L., Kenny A.D., Magee A.D., Meade G.K., Waters M.S. (2011). Single nucleotide polymorphisms in the insulin-like growth factor 1 (IGF-1) gene are associated with performance in Holstein-Friesian dairy cattle. Front. Genet., 2: 1-9. Nal N., Ahmed M.Z., Erkal E

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Receptors and Binding Proteins for Insulin and Insulin-Like Growth Factors in the Placenta of Healthy Mothers and Mothers with Insulin-Dependent Diabetes Mellitus

. Insulin-like growth factors I and II regulate the life cycle of trophoblast in the developing human placenta. Am J Physiol Cell Physiol 2008; 294: C1313-22. Humbel RE. Insulin-like growth factors I and II. Eur J Biochem 1990; 190: 445-62. Sörensen H, Whittaker L, Hinrichsen J, Groth A, Whittaker J. Mapping of the insulin-like growth factor II binding site of the type I insulin-like growth factor receptor by alanine scanning mutagenesis. FEBS Lett 2004; 565: 19-22. Braulke T. Type-2 IGF

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Insulin-like growth factor 1 receptor expression in advanced non-small-cell lung cancer and its impact on overall survival

overcome the resistance mechanisms new molecular alterations in different other co-activated pathways are extensively sought. The insulin-like growth factor 1 receptor (IGF1R) signalling pathway has been shown to promote oncogenic transformation and cancer cell growth and survival 8 , 9 and has been associated with resistance to specific oncologic therapies in various human cancers 10 - 12 , including EGFR-TKI 13 , 14 and ALK-TKI 15 in NSCLC. With various lines of evidence supporting IGF1R signalling pathway as a potential target for cancer therapy, different anti-IGF

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Effect of hypoxia on the expression of genes encoding insulin-like growth factors and some related proteins in U87 glioma cells without IRE1 function

References Abu Shehab M, Damerill I, Shen T, Rosario FJ, Nijland M, Nathanielsz PW, Kamat A, Jansson T, Gupta MB. Liver mTOR controls IGF-I bioavailability by regulation of protein kinase CK2 and IGFBP-1 phosphorylation in fetal growth restriction. Endocrinology 155, 1327-1339, 2014. Acosta-Alvear D, Zhou Y, Blais A, Tsikitis M, Lents NH, Arias C, Lennon CJ, Kluger Y, Dynlacht DD. XBP1 controls diverse cell type- and condition-specifi c transcriptional regulatory networks. Molecular Cell 27, 53-66, 2007. Aragon

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The Association of Four Polymorphisms within the Insulin-Like Growth Factor 1 Receptor Gene with Milk Production Traits in Simmental Cows

References Bali V., Bebok Z. (2015). Decoding mechanisms by which silent codon changes influence protein biogenesis and function. Int. J. Biochem. Cell Biol., 64: 58-74. Baumrucker C.R., Erondu N.E. (2000). Insulin-like growth factor (IGF) system in the bovine mammary gland and milk. J. Mammary Gland Biol. Neoplasia, 5: 53-64. Blott S., Kim J.J., Moisio S., Schmidt- Kuntzel A., Cornet A., Berzi P., Cambisa- no N., Ford C., Grisart B., Johnson D., Karim L., Simon P., Snell R., Spelma n R., Wong J., Vilkki J

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