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References 1. Abdel-Gayoum A.A., Ali B.H., Abdel-Razig K.M., Bashir A.A., Ghywarsha K.: Effect of gentamicin-induced nephrotoxicity on some carbohydrate metabolic pathways in the rat renal cortex. Arch Toxicol 1994, 68, 643-647. 2. Abdel-Raheem I.T., Abdel-Ghany A.A., Mohamed G.A.: Protective effect of quercetin against gentamicin-induced nephrotoxicity in rat. Biol Pharm Bull 2009, 32, 61-67. 3. Balakumar P., Rohilla A., Thangathirupathi A.: Gentamicin- induced nephrotoxicity: Do we have a promising therapeutic approach to blunt it? Pharmacol Res 2010, 62, 179

References [1] Martin J, Barras M, Ah Yui N, Kirkpatrick C, Kubler P, No R: Gentamicin monitoring practices in teaching hospitals – time to undertake the necessary randomised controlled trial. J Clinic Toxicol. 2012;2(8):1–5. [2] Durante-Mangoni E, Grammaticos A, Utili R, Falagas ME: Do we still need the aminoglycosides? Int J Antimicrob Agents. 2009;33(3):201–205. [3] Gómolka M, Niemczyk S: How to safely and effectively administer aminoglycoside antibiotics. Pol. Merkur. Lekarski. 2014;36(214):225–228. [4] Solomkin JS, Mazuski JE, Bradley JS et al. Diagnosis and

References 1. Martinez-Salgado, C., Lopez-Hernandez, F. J., Lopez-Novoa, J. M. (2007). Glomerular nephrotoxicity of aminoglycosides. Toxicology and applied pharmacology, 223(1), 86-98, https://doi.org/10.1016/j.taap.2007.05.004 2. Balakumar, P., Rohilla, A., Thangathirupathi, A. (2010). Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it?. Pharmacological Research, 62(3), 179-186, https://doi.org/10.1016/j.phrs.2010.04.004 3. Bennett, J. E., Dolin, R., Blaser, M. J. Mandell, Douglas. (2015). Bennett's principles and practice

, the development and screening of early diagnostic markers is of great significance for early diagnosis and prognosis of AKI. In this study, we established an AKI model by injecting experimental dogs with gentamicin and then performed comparative analysis for screening early diagnostic markers of canine AKI. This study was a preliminary exploration of early diagnostic and warning indicators of this renal impairment in dogs, meant to provide a scientific basis for further studies on early diagnosis of canine acute kidney injury. Material and Methods Animals . For this

of gentamicin peak concentrations: Use of a simple and practical tool. PatholBiol (Paris) 59, 2, 2011, p. 79 - 82. VARON, J. - MARIK, P.: Management of the Obese Critically Ill Patient. Crit Care Clin 17, 1, 2001, p. 187 - 200. ROBERT, S. - ZAROWITZ, B.: Is there a reliable index of glomerular filtration rate in critically ill patients? DICP Ann Pharmacother 25, 2, 1991, p. 169 - 178. SAWYER W., T. - CANADAY, B., R. - POE, T., E.: Variables affecting creatinine prediction. Am J Hosp Pharm 40, 12, 1983, p. 2175 - 90. EVANS, W., E -OELRICH, M. - HOLTZ, D., W

Sophora flavescens. Biol Pharm Bull. 2006; 29: 1911-5. 14. Fakhimi A, Iranshahi M, Emami SA, Amin-Ar-Ramimeh E, Zarrini G, Shahverdi AR. Sophoraflavanone G from Sophora pachycarpa enhanced the antibacterialactivity of gentamicin against Staphylococcus aureus. Z Naturforsch C. 2006; 61:769-72. 15. Cha JD, Jeong MR, Jeong SR, Lee. Antibacterial activity of sophoraflavanone G isolated from the roots of Sophora flavescens. J Microbiol Biotechnol. 2007; 17:858-64. 16. Odenholt I, Gustafsson I, Löwdin E. Postantibiotic and sub-MIC effects of benzylpenicillin against

References Musso CG. Aminoglycoside and nephropathy. Electron J Biomed 2004; 2: 2-4. Cuzzocrea S, Mazzon E, Dugo L, Serraino I, Di Paola R, Britti D, et al. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur J Pharmacol 2002; 450: 76-6. Trajtnar F. Urinary enzymes as indicators of aminoglycoside nephrotoxicity. Folia Pharm Univ Carol 1995; 19: 91-9. Whiting PH, Brown J. The relationship between enzymuria and kidney enzyme activities in experimental gentamicin nephrotoxicity. Ren Fail 1996; 18 (6): 899-909. Van der Harst MR, Bull S

References Musso CG. Aminoglycosides and nephropathy. Electron J Biomed 2004; 2: 2-4. Cuzzocrea S, Mazzon E, Dugo L Serraino I, Di Paola R, Britti D, et al. A role for superoxide in gentamicin-mediated nephropathy in rats. Eur J Pharmacol 2002; 450: 76-9. Trajtnar F. Urinary enzymes as indicators of aminoglycoside nephrotoxicity. Folia Pharm Univ Carol 1995; 19: 91-9. Van der Harst MR, Bull S, Laffont CM, Klein WR. Gentamicin nephrotoxicity - a comparison of in vitro findings with in vivo experiments in equines. Vet Res Commun 2005; 29: 247-61. Lenz FM

On the other hand, the recent emergence of technologies such as resorbable implants offers new possibilities to protect the anastomosis and reduce the consequences of leakage. Hence we reported the wrapping of anastomosis with the gentamicin-collagen sponge (GCS) as a potential preventive manoeuvre against the AL – probably limiting the leakage intensity and reducing its clinical symptoms. 3 , 4 It encouraged us to continue the study with more patients and longer follow-up in order to obtain more reliable and objective results as well as for more robust

from gentamicin ear drops. Can Urol Assoc J 2002; 167(1):56. doi: http://dx.doi.org/10.1080/00016480119705 18. Mahboubi M, Haghi G. Antimicrobial activity and chemical composition of Mentha pulegium L. essential oil. J Ethnopharmacol 2008; 119(2):325-327. doi: http://dx.doi.org/10.1016/j.jep.2008.07.023 19. Mahboubi M, Bidgoli F. Antistaphylococcal activity of Zataria multiflora essential oil and its synergy with vancomycin. Phytomedicine 2010; 17(7):548-550. doi: http://dx.doi.org/10.1016/j.phymed.2009.11.004 20. Avijgan M, Mahboubi M, Nasab MM, Nia EA