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Feasibility of withholding dexamethasone premedication for hypersensitivity reactions associated with paclitaxel administration

Premedication with dexamethasone, an antagonist of histamine-1 (H1) and histamine-2 (H2) receptors, is a crucial part of the prevention of hypersensitivity reactions (HSRs) associated with administration of taxanes. Although studies of the excipient Cremophor EL (Kolliphor EL) have contributed important knowledge to the mechanism of the paclitaxel HSR, the exact mechanism remains uncertain. Several risk factors, such as menopausal status, high body mass index (BMI), and history of allergy or asthma, have been demonstrated, and might play a role in the

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Original article. Efficacy of intravenous dexamethasone for the prevention of vomiting associated with intrathecal chemotherapy and ketamine sedation in children: a randomized, double-blinded, crossover, placebocontrolled trial

. Dexamethasone as an antiemetic in patients treated with cisplatin. N Engl J Med. 1981; 305:520. 16. Markman M, Sheidler V, Ettinger DS, Quaskey SA, Mellits ED. Antiemetic efficacy of dexamethasone. Randomized, double-blind, crossover study with prochlorperazine in patients receiving cancer chemotherapy. N Engl J Med. 1984; 311:549-52. 17. Holte K, Kehlet H. Perioperative single-dose glucocorticoid administration: pathophysiologic effects and clinical implications. J Am Coll Surg. 2000; 195: 694-712. 18. Olver I, Clark-Snow RA

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Choriocarcinoma cell line Response to Dexamethasone

, Hass M, Brew K, Miller T, Werner R, Massaro D. Sequence of full-length cDNA for rat lung beta-galactoside-binding protein: primary and secondary structure of the lectin. Biochemistry 1988; 27, 692-9. Sandford GL, Owens MA, Odusanya BM. Differential influence of dexamethasone on the activity and synthesis of β-galactoside-specific lectin (galaptin) during postnatal lung development. Exp Lung Res 1993; 19: 91-104. Karalis K, Goodvin G, Majzoub JA. Cortisol blockade of progesterone: a possible molecular mechanism

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Changes of Spleen in Wistar Rats Exposed to Therapeutic Doses of Dexamethasone and Medroxyprogesterone Acetate Evaluated by Stereological Parameters

References 1. Chung HT, Samlowski WE, Daynes RA. Modification of the murine immune system by glucocorticoids: alterations of the tissue localization properties of circulating lymphocytes. Cellular immunology. 1986; 101: 571-585. 2. Van Vliet E, Melis M, van Evijk W. The influence of dexamethasone treatment on the lymphoid and stromal composition of the mouse thymus: a flowcytometric and immunohistological analysis. Cellular Immunology. 1986; 103: 229-240. 3. Wyllie AH, Morris RG. Hormone-induced cell death

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in PRILOZI
Effect of Adding Dexamethasone as a Ropivacaine Adjuvant in Ultrasound-Guided Transversus Abdominis Plane Block for Inguinal Hernia Repair

corticosteroids on the sciatic nerve: an experimental study to adduce the safety in treating carpal tunnel syndrome, J Hand Surg Eur. 2011; Vol 36: 236-43. 16. Shishido H, Kikuchi S, Heckman H, Myers RR. Dexamethasone decreases blood flow in normal nerves and dorsal root ganglia. Spine. 2002; 27: 581-6. 17. Barnes PJ. Anti-inflammatory actions of glucocorticoids: molecular mechanisms. Clin Sci. 1998; 94: 557-72. 18. Choi S, Rodseth R, McCartney CJ. Effects of dexamethasone as a local anaesthetic adjuvant for brachial plexus block

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in PRILOZI
Comparison of the Safety and Efficacy of Intravitreal Ranibizumab with or without Laser Photocoagulation Versus Dexamethasone Intravitreal Implant with or without Laser Photocoagulation for Macular Edema Secondary to Branch Retinal Vein Occlusion

Ophthalmol 2012;60:263-6. 8. Yeh W, Haller JA, Lanzetta P, et al. Effect of the duration of macular edema on clinical outcomes in retinal vein occlusion treated with dexamethasone intravitreal implant. Ophthalmology 2012; 119: 1190-8. 9. Holash J, Davis S, Papadopoulos N, et al. VEGF-Trap: A VEGF blocker with potent antitumor effects. Proc Natl Acad Sci USA 2012; 99: 11293-98. 10. Pfister M, Rothweiler F, Michaelis M, et al. Correlation of inflammatory and proangiogenic cytokines from undiluted vitreous samples with spectral domain OCT scans, in untreated

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Maternal Glucocorticoid Treatment as a Model for Examining Foetal Gender-Specific Effects on the Bone Metabolism of Neonatal Piglets

References 1. Céleste C., Ionescu M., Poole A.R., Laverty S.: Repeated intraarticular injections of triamcinolone acetonide alter cartilage matrix metabolism measured by biomarkers in synovial fluid. J Orthopc Res 2005, 23, 602-610. 2. Bertram C.E., Hanson M.A.: Prenatal programming of postnatal endocrine responses by glucocorticoids. Reproduction 2002, 124, 459-467. 3. Bloom S.L., Sheffield J.S., McIntire D.D., Leveno K.J.: Antenatal dexamethasone and decreased birth weight. Obstet Gynecol 2001, 97, 485

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Corticosteroids in oncology: An overview

contribution of steroids in patients receiving whole-brain irradiation for cerebral metastases. Clin Oncol (R Coll Radiol) 2004;16:339-44. 11. Edwards MS, Prados M. Current management of brain stem gliomas. Pediatr Neurosci 1987;13:309-15. 12. Hempen C, Weiss E, Hess CF. Dexamethasone treatment in patients with brain metastases and primary brain tumors: Do the benefits outweigh the side-effects? Support Care Cancer 2002;10:322-8. 13. Weissman DE. Glucocorticoid treatment for brain metastases and epidural spinal cord compression

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Effects of Chronic Psychosocial Stress on Reduction of Basal Glucocorticoid Levels and Suppression of Glucocorticoid Levels Following Dexamethasone Administration in Animal Model of PTSD

;68(5):748-66. 4. Yehuda R, Halligan SL, Golier JA, Grossman R, Bierer LM.Effects of trauma exposure on the cortisol response to dexamethasone administration in PTSD and major depressive disorder. Psychoneuroendocrinology. 2004;29 (3): 389-404. 5. Bremner JD, Elzinga B, Schmahl C, Vermetten E. Structural and functional plasticity of the human brain in posttraumatic stress disorder. Prog Brain Res. 2008; 167: 171-186 6. Yehuda R, Boisoneau D, Lowy MT, Giller Jr EL. Doseresponse changes in plasma cortisol and lymphocyte glucocorticoid receptors

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Antenatal Treatment with Glucocorticoids and the Hypotalamic-Pituitary-Adrenal Axis

References 1. Andrews MH, Wood SA, Windle RJ, Lightman SL, Ingram CD. Acute glucocorticoid administration rapidly suppresses basal and stress-induced hypothalamo-pitu-itary-adrenal axis activity. Endocrinology 2012; 153: 200–11. 2. Negić N, Nestorović N, Manojlović-Stojanoski M, Filipović B, Šošić-Jurjevic B, Trifunović S, Milosević V, Sekulić M. Pregnancy and dexamethasone: Effects on morphometric parameters of gonadotropic cells in rats. Acta Histochem 2007; 109: 185–92. 3. Godfrey KM, Barker DJP. Fetal programming and adult health. Public Health

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