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1 Introduction Prostate cancer (PC) represents 19% of the newly diagnosed male cancer cases of 2017 and is the second cause of cancer-related deaths . [ 1 ] PC is not one disease , the heterogeneity is reflected through the different clinical behavior. This mandated the need for biomarkers that help in therapy selection and proper diagnosis in difficult circumstances. Dysregulation of cell cycle regulating genes is believed to play a major part in cancers. Cyclin D1 is the key regulator during the G1 phase and overexpression was associated with malignant

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. Shireman, J. Tay-Sontheimer and Y. S. Lin, Interindividual variability in cytochrome P450-mediated drug metabolism, Drug Metab. Dispos . 44 (2016) 343–351; 20. J. Kirchheiner and J. Brockmöller, Clinical consequences of cytochrome P450 2C9 polymorphisms, Clin. Pharmacol. Ther . 77 (2005) 1–16; 21. A. S. Chaudhry, R. K. Thirumaran, K. Yasuda, X. Yang, Y. Fan, S. C. Strom and E. G. Schuetz, Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of

Phosphorylation and Ordering the Cell Cycle, Cell. 167 (2016) 1750–1761 e1716; 26. U. Galderisi, F. P. Jori and A. Giordano, Cell cycle regulation and neural differentiation, Oncogene 22 (2003) 5208–5219; 27. D. Ye, H. Luo, Z. Lai, L. Zou, L. Zhu, J. Mao, T. Jacob, W. Ye, L. Wang and L. Chen, ClC-3 Chloride Channel Proteins Regulate the Cell Cycle by Up-regulating cyclin D1-CDK4/6 through Suppressing p21/p27 Expression in Nasopharyngeal Carcinoma Cells, Sci. Rep. 6 (2016) 30276; https

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)-ones, Biological and Pharmaceutical Bulletin 26 (2003) 557 - 559. [19]. V. Alagarsamy, R. Rajesh, R. Meena, S. Vijaykumar, K.V. Ramseshu, T.D. Anandakumar, Synthesis, analgesic and anti-inflammatory and antibacterial activities of some novel 2-methylthio - 3 - substituted quinazolin - 4 (3H)-ones, Biological and Pharmaceutical Bulletin 27 (2004) 652 - 656. [20]. P.O. Osarumwense, O. Iyekowa, Synthesis and antibacterial activity of 7-chloro-2-methyl-4H-benzo[d] [1,3] - oxazin-4-one and 3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one, Tropical Journal of Natural Product Research

antimycobacterial activity of tetrazole and oxadiazole derivatives, Pharmazie 60 (2005) 396-397. A. Rajasekaran and P. P. Thampi, Synthesis and analgesic evaluation of some 5-[beta-(10-phenothiazinyl) ethyl]-1-(acyl)-1,2,3,4-tetrazoles, Eur. J. Med. Chem. 39 (2004) 273-279; DOI: 10.1002/chin.200433179. A. Rajasekaran, S. Murugesan and K. Anandarajagopal, Antibacterial, antifungal and anticonvulsant evaluation of newly synthesized 1-1-[2-(1 H -tetrazol-5-yl)ethyl]-1 H -benzo[ d ][1,2,3]triazoles, Arch. Pharm. Res. 29 (2006) 535-540. U. S. Göksen, N. G. Kelekçi, O. Göktas, Y

observation of r.f. transitions and laser beat resonances in oriented Na vapour. Il Nuovo Cimento B 36 (1) 5-20 DOI: 10.1007/BF02749417 Dancheva, Y., Alzetta, G., Cartalava, S., Taslakov, M., & Andreeva, C. (2000). Coherent effects on the Zeeman sublevels of hyperfine states in optical pumping of Rb by monomode diode laser. Optics Communications, 178 (1-3), 103-110. DOI: 10.1016/S0030-4018(00)00643-X Auzinsh, M., Ferber, R., Gahbauer F., Jarmola, A., & Kalvans, L. (2009). Nonlinear magneto-optical resonances at D 1 excitation of 85 Rb and 87 Rb for partially resolved

-3766; DOI: 10.1016/j.bmcl.2005.05.127. 7. T. Horiuchi, J. Chiba, K. Uoto and T. Soga, Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone- based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships, Bioorg. Med. Chem. Lett. 19 (2009) 305-308; DOI: 10.1016/j.bmcl.2008.11.090. 8. A. Angell, C. McGuigan, L. G. Sevillano, R. Snoeck, G. Andrei, E. De Clercq and J. Balzarini, Bicyclic anti-VZV nucleosides, Bioorg. Med. Chem. Lett. 14 (2004) 2397-2399; DOI: 10.1016/j.bmcl.2004.03.029. 9. A. Brancale, C. McGuigan, B. Algain, P