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1 Introduction Prostate cancer (PC) represents 19% of the newly diagnosed male cancer cases of 2017 and is the second cause of cancer-related deaths . [ 1 ] PC is not one disease , the heterogeneity is reflected through the different clinical behavior. This mandated the need for biomarkers that help in therapy selection and proper diagnosis in difficult circumstances. Dysregulation of cell cycle regulating genes is believed to play a major part in cancers. Cyclin D1 is the key regulator during the G1 phase and overexpression was associated with malignant

REFERENCES Alt, J. R., Cleveland, J. L., Hannink, M., Diehl, J. A. (2000). Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformation. Genes Devel., 14 (24), 3102–3114. Athanasiou, E., Kaloutsi, V., Kotoula, V., Hytiroglou, P., Kostopoulos, I., Zervas, C., Kalogiannidis, P., Fassas, A., Christakis, J. I., Papadimitriou, C. S. (2001). Cyclin D1 Overexpression in Multiple Myeloma. Amer. J. Clin. Pathol., 116 , 535–542. Chang, H., Samiee, S., Yi. Q. L. (2006). Prognostic relevance of CD56 expression in

. Shireman, J. Tay-Sontheimer and Y. S. Lin, Interindividual variability in cytochrome P450-mediated drug metabolism, Drug Metab. Dispos . 44 (2016) 343–351; https://doi.org/10.1124/dmd.115.067900 20. J. Kirchheiner and J. Brockmöller, Clinical consequences of cytochrome P450 2C9 polymorphisms, Clin. Pharmacol. Ther . 77 (2005) 1–16; https://doi.org/10.1016/j.clpt.2004.08.009 21. A. S. Chaudhry, R. K. Thirumaran, K. Yasuda, X. Yang, Y. Fan, S. C. Strom and E. G. Schuetz, Genetic variation in aldo-keto reductase 1D1 (AKR1D1) affects the expression and activity of

Phosphorylation and Ordering the Cell Cycle, Cell. 167 (2016) 1750–1761 e1716; https://doi.org/10.1016/j.cell.2016.11.034 26. U. Galderisi, F. P. Jori and A. Giordano, Cell cycle regulation and neural differentiation, Oncogene 22 (2003) 5208–5219; https://doi.org/10.1038/sj.onc.1206558 27. D. Ye, H. Luo, Z. Lai, L. Zou, L. Zhu, J. Mao, T. Jacob, W. Ye, L. Wang and L. Chen, ClC-3 Chloride Channel Proteins Regulate the Cell Cycle by Up-regulating cyclin D1-CDK4/6 through Suppressing p21/p27 Expression in Nasopharyngeal Carcinoma Cells, Sci. Rep. 6 (2016) 30276; https

References Sherr CJ. Cancer cell cycles. Science 1996; 274 (5293): 1672-1677. Solomon DA, Wang Y, Fox SR, Lambeck TC, Giesting S, Lan Z, Senderowicz AM, Conti CJ, Knudsen ES. Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformation. J Biol Chem 2003; 278 (32): 30339-30347. Knudsen KE, Diehl JA, Haiman CA, Knudsen ES. Cyclin D1: polymorphism, aberrant splicing and cancer risk. Oncogene 2006; 25(11): 1620-1628. Knudsen KE. The cyclin D1b splice variant: an old oncogene learns new tricks. Cell Div 2006

. Expression of the HER1-4 family of receptor tyrosine kinases in breast cancer. J Pathol 2003; 200: 290-7. 6. Sherr CJ. Cancer cell cycles. Science 1996; 274: 1672-7. 7. Andrew Arnold, Papanikolaou A. Cyclin D1 in Breast Cancer Pathogenesis. J Clin Oncol 2005; 23: 4215-24. 8. Liao DJ, Dickson RB. c-Myc in breast cancer. Endocrine- Related Cancer 2000; 7: 143-164. 9. Bloom HJ, Richardson WW. Histological grading and prognosis in breast cancer. A study of 1409 cases of which 359 have been followed for 15 years. Br J Cancer 1957; 11: 359-77. 10. Leake R, Barnes D, Pinder S

)-ones, Biological and Pharmaceutical Bulletin 26 (2003) 557 - 559. [19]. V. Alagarsamy, R. Rajesh, R. Meena, S. Vijaykumar, K.V. Ramseshu, T.D. Anandakumar, Synthesis, analgesic and anti-inflammatory and antibacterial activities of some novel 2-methylthio - 3 - substituted quinazolin - 4 (3H)-ones, Biological and Pharmaceutical Bulletin 27 (2004) 652 - 656. [20]. P.O. Osarumwense, O. Iyekowa, Synthesis and antibacterial activity of 7-chloro-2-methyl-4H-benzo[d] [1,3] - oxazin-4-one and 3-amino-7-chloro-2-methyl-quinazolin-4(3H)-one, Tropical Journal of Natural Product Research

antimycobacterial activity of tetrazole and oxadiazole derivatives, Pharmazie 60 (2005) 396-397. A. Rajasekaran and P. P. Thampi, Synthesis and analgesic evaluation of some 5-[beta-(10-phenothiazinyl) ethyl]-1-(acyl)-1,2,3,4-tetrazoles, Eur. J. Med. Chem. 39 (2004) 273-279; DOI: 10.1002/chin.200433179. A. Rajasekaran, S. Murugesan and K. Anandarajagopal, Antibacterial, antifungal and anticonvulsant evaluation of newly synthesized 1-1-[2-(1 H -tetrazol-5-yl)ethyl]-1 H -benzo[ d ][1,2,3]triazoles, Arch. Pharm. Res. 29 (2006) 535-540. U. S. Göksen, N. G. Kelekçi, O. Göktas, Y

observation of r.f. transitions and laser beat resonances in oriented Na vapour. Il Nuovo Cimento B 36 (1) 5-20 DOI: 10.1007/BF02749417 Dancheva, Y., Alzetta, G., Cartalava, S., Taslakov, M., & Andreeva, C. (2000). Coherent effects on the Zeeman sublevels of hyperfine states in optical pumping of Rb by monomode diode laser. Optics Communications, 178 (1-3), 103-110. DOI: 10.1016/S0030-4018(00)00643-X Auzinsh, M., Ferber, R., Gahbauer F., Jarmola, A., & Kalvans, L. (2009). Nonlinear magneto-optical resonances at D 1 excitation of 85 Rb and 87 Rb for partially resolved

-3766; DOI: 10.1016/j.bmcl.2005.05.127. 7. T. Horiuchi, J. Chiba, K. Uoto and T. Soga, Discovery of novel thieno[2,3-d]pyrimidin-4-yl hydrazone- based inhibitors of cyclin D1-CDK4: synthesis, biological evaluation, and structure-activity relationships, Bioorg. Med. Chem. Lett. 19 (2009) 305-308; DOI: 10.1016/j.bmcl.2008.11.090. 8. A. Angell, C. McGuigan, L. G. Sevillano, R. Snoeck, G. Andrei, E. De Clercq and J. Balzarini, Bicyclic anti-VZV nucleosides, Bioorg. Med. Chem. Lett. 14 (2004) 2397-2399; DOI: 10.1016/j.bmcl.2004.03.029. 9. A. Brancale, C. McGuigan, B. Algain, P