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References 1. Papillon MM, Lefevre P. Twocases of symmetrically familial palmar and plantar hyperkeratosis (Meledadisease) within brother and sister combined with severe dental alterations in both cases (in French). Bull Soc Fr Dermatol Syph, 1924;31:82-84 2. Wani AA, Devkar N, Patole MS, Shouche YS. Description of two new cathepsin C gene mutations in patients with Papillon-Lefèvre syndrome. J Periodontol, 2006;77:233-237. 3. Hattab FN, Rawashdeh MA, Yassin OM, al-Momani AS, al-Ubosi M. Papillon-Lefèvre syndrome: a review of the literature and report of 4 cases

granzyme A are needed for cytotoxicity. 5 As well as perforin and granzymes, cytotoxic granules contain certain cysteine cathepsins. These comprise a group of 11 cysteine peptidases (cathepsins B, C, F, H, K, L, O, S, V, X and W) exhibiting different tissue distributions, cellular localisations, proteolytic activities and protein levels, all involved in a variety of physiological and pathological processes. In CTLs the most notable is the role of cathepsin C, which is responsible for the activation of pro-granzymes by removing an N-terminal dipeptide. 6 However