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, Toutant J, Elela SA, Chabot B.Anticancer drugs affect the alternative splicing of Bcl-x and other human apoptotic genes. Mol Cancer Ther. 2008;7:1398-409. 10.1158/1535-7163.MCT-08-0192 6. Druker BJ, Tamura S, Buchdunger E, Ohno S, Segal GM, Fanning S, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996; 2:561-66. 10.1038/nm0596-561 7. Hughes T, Deininger M, Hochhaus A, Branford S, Radich J, Kaeda J, et al. Monitoring CML patients responding to treatment with tyrosine kinase inhibitors: review and

MB. Control of myeloid differentiation and survival by Stats. Oncogene. 2000;19:2612-8. 10. Huang M, Page C, Reynolds RK, Lin J. Constitutive activation of stat 3 oncogene product in human ovarian carcinoma cells. Gynecol Oncol 2000; 79: 67-73. 11. Xie TX, Huang FJ, Aldape KD, Kang SH, Liu M, Gershenwald JE, Xie K, Sawaya R, Huang S. Activation of stat3 in human melanoma promotes brain metastasis. Cancer Res. 2006;66:3188-96. 12. Boise LH, Gonzalez-Garcia M, Postema CE, Ding L, Lindsten T, Turka LA, Mao X, Nunez G, Thompson CB. bcl-x, a bcl-2-related gene that

, Barbareschi M, Viale G. The prevalence of BCL-2 immunoreactivity in breast carcinomas and its clinicopathological correlates, with particular reference to oestrogen receptor status. Virchows Arch 1994; 424(1): 47-51. Krajewska M, Krajewski S, Epstein JI, Shabaik A, Sauvageot J, Song K, Kitada S, Reed JC. Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers. Am J Pathol 1996; 148(5): 1567-76. Singhal S, Amin KM, Kruklitis R, Marshall MB, Kucharczuk JC, DeLong P, Litzky LA, Kaiser LR, Albelda SM. Differentially expressed apoptotic genes

, Gomes TS, Neto RA, et al. The intrinsic apoptotic signaling pathway in gastric adenocarcinomas of Brazilian patients: Immunoexpression of the Bcl-2 family (Bcl-2, Bcl-x, Bak, Bax, Bad) determined by tissue microarray analysis. Mol Med Report 2010; 3 : 261-7. Chami M, Prandini A, Campanella M, Pinton P, Szabadkai G, Reed JC, et al. Bcl-2 and bax exert opposing effects on Ca 2+ signaling, which do not depend on their putative pore-forming region. J Biol Chem 2004; 279 : 54581-9. Samuel MS, Lopez JI, McGhee EJ, Croft DR, Strachan D, Timpson P, et al. Actomyosin

, Wilkinson JC, Yu C, Oliver PG, Duckett CS, Buchsbaum DJ, LoBuglio AF, Jordan VC, Cryns VL. The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. J Biol Chem 2005;280:11059-66. 46. Mao YW, Liu JP, Xiang H, Li DW. Human alphaA- and alphaB-crystallins bind to Bax and Bcl-X(S) to sequester their translocation during staurosporine-induced apoptosis. Cell Death Differ 2004;11:512-26. 47. Kirbach BB, Golenhofen N. Differential expression and induction of small heat shock proteins in rat brain

lipofection. Theriogenology, 70: 248-259. Telford W.G., King L.E., Fraker P.J. (1992). Comparative evaluation of several DNAbinding dyes in the detection of apoptosis associated chromatin degradation by flow cytometry. Cytometry, 13: 137-143. Todt F., Cakir Z., Reichenbach F., Youle R.J., Edlich F. (2013). The C-terminal helix of Bcl-x Lmediates Bax retrotranslocation from the mitochondria. Cell Death Differ., 20: 333-342. Whitworth K.M., Zhao J., Spate L.D., Li R., Prather R.S. (2011). Scriptaid corrects gene expression ofafew aberrantly reprogrammed transcripts in nuclear

human tumor cell lines with different p53 status. Strahlentherapie und Onkol. 2003; 179:99–106. Oya N Zölzer F Werner F Streffer C Effects of serum starvation on radiosensitivity, proliferation and apoptosis in four human tumor cell lines with different p53 status Strahlentherapie und Onkol 2003 179 99 106 [4] Braun F, Bertin-Ciftci J, Gallouet AS, Millour J, Juin P. Serum-nutrient starvation induces cell death mediated by bax and puma that is counteracted by p21 and unmasked by Bcl-x L inhibition. PLoS One. 2011; 6:e23577. Braun F Bertin-Ciftci J Gallouet AS Millour

. Cell Biol. 144: 891-901. Droin, N. M., Green, D. R. 2004. Role of Bcl-2 family members in immunity and disease. Biochim. Biophys. Acta. 1644: 179-188. Ewings, K. E., Hadfield-Moorhouse, K., Wiggins, C. M., Wickenden, J. A., Balmanno, K., Gilley, R., Degenhardt, K., White, E., Cook, S. J. 2007. ERK1/2-dependent phosphorylation of Bim EL promotes its rapid dissociation from Mcl-1 and Bcl-X L . EMBO J. 26: 2856-2867. Falke, D., Fisher, M., Ye, D., Juliano, R. L. 2003. Design of artificial transcription factors to selectively regulate the pro-apoptotic bax gene. Nucleic

References Abe T, Takngi N, Nagano M, Furuza M, Takeo S (2004). Altered Bad localization and interaction between Bad and Bcl-X L in the hippocampus after transient global ischemia. Brain Res   1009 : 159-168. Acuna-Castroviejo D, Coto-Montes A, Gaia Monti M, Ortiz GG, Reiter RJ (1997). Melatonin is protective against MPTP-induced striated and hippocampal lesions. Life Sci   60 , PL23-PL29. Acuna-Castroviejo D, Escames G, Carozo A, Leon J, Khaldy H, Reiter RJ (2002). Melatonin, mitochondrial homeostasis and mitochondrial-related diseases. Curr Top Med Chem   2

, 18 ] These intracellular changes culminate in the activation of Nuclear Factor kappa-B (NF-κB) [19] and other transcription factors, which then regulate the expression of genes related to B-cell survival, development and proliferation, such as Bcl-X L . [5] Of note, Btk upregulates phosphatidylinositol 5-phosphate kinase (PIP5K), the enzyme responsible for producing PIP 2 , which is a substrate for both PI3K and PLCγ2, thus enhancing their activity, [20] while it also plays a role in B-cell migration and adhesion.[ 21 , 22 ] B-cell Receptor (BCR) signalling