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Bcl-2 Family Overexpression and Chemoresistance in Acute Myeloid Leukemia

REFERENCES 1. Abdel-Magid A. F. (2015). Inhibitors of the Antiapoptotic Myeloid Cell Leukemia-1 (Mcl-1) May Provide Effective Treatment for Cancer. ACS Medical Chemistry Letter, 6: 1171–1173. dx.doi.org/10.1021/acsmedchemlett.5b00438 2. AlBakr R. B, Khojah O. T. (2014). Incidence Trend of the Leukemia Reported Cases in the Kingdom of Saudi Arabia, Observational Descriptive Statistic from Saudi Cancer Registry. International Journal Biomedical Research, 5(8). 3. Anderson M. A, Huang D, Robertsa A. 2014. Targeting BCL2 for the Treatment of

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Main Pro-Apoptotic Member of BCL-2 Family Proteins-BAX

References Apte, S. S., Mattei, M. G., Olsen, B. R. 1995. Mapping of the human bax gene to chromosome 19q13.3-13.4 and isolation of a novel alternatively spliced transcript Bax delta. Genomics 26: 592-594. Bargou, R. C., Bommert, K., Weinmann, P., Daniel, P. T., Wagener, C., Mapara, M. Y., Dörken, B. 1995. Expression of the bcl-2 gene family in normal and malignant breast tissue: low bax-alpha expression in tumor cells correlates with resistance towards apoptosis. Eur. J. Immunol. 25: 770

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Expression Of The Bcl2 Gene In Chronic Lymphocytic Leukaemia Patients

ABBREVIATIONS Bcl2 - B-cell lymphoma 2 CLL - Chronic lymphocytic leukaemia mRNA – messenger ribonucleic acid miRNA - micro ribonucleic acid qRT-PCR - quantitative reverse-transcriptase polymerase chain reaction REFERENCES 1. Sagatys EM, Zhang L. Clinical and laboratory prognostic indicators in chronic lymphocytic leukemia. Cancer Control 2012;19(1):18-25. 2. Chiorazzi N. Implications of new prognostic markers in chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program 2012;2012:76-87. 3. Obermann EC, Went P

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Prognostic Significance of Bcl-2, C-Myc, Survivin and Tumor Grade in Synovial Sarcoma / Sinovyal Sarkom Olgularında Bcl-2, C-Myc, Survivin ve Tümör Derecesinin Prognostik Değeri

Tissue and Bone. Lyon: IARC Press; 2013. 213-5. 13. Krskova L, Kalinova M, Brizova H, Mrhalova M, Sumerauer D, Kodet R. Molecular and immunohistochemical analyses of BCL2, KI-67, and cyclin D1 expression in synovial sarcoma. Cancer Genet Cytogenet. 2009;193:1-8. 14. Tsiatis AC, Herceg ME, Keedy VL, Halpern JL, Holt GE, Schwartz HS, Cates JM. Prognostic significance of c-Myc expression in soft tissue leiomyosarcoma. Mod Pathol. 2009;22:1432-8. 15. Shen J, Scotlandi K, Baldini N, Manara MC, Benini S, Cerisano V, Picci P

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Bcl-2 Family Proteins in Development and Treatment of Malignant Diseases

References Hotchkiss RS, Strasser A, McDunn JE, Swanson PE. Cell death. N Engl J Med 2009; 361(16): 1570-83. Jin Z, El-Deiry WS. Overview of cell death signalling pathways. Cancer Biol Ther 2005; 4(2): 139-163. Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene 2003; 22(53): 8543-67. Youle RJ, Strasser A. The BCL-2 family proteins: opposite activities that mediate cell death. Nat. Rev. Mol. Cell Biol 2008; 9(1): 47

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Muscle-Invasive Transitional Cell Carcinoma of the Urinary Bladder is Associated with Down-Regulated CPP32 Expression and BCL-2 Positivity

-9. Kim HS, Lee JW, Suong JH, et al. Inactivating mutations of caspase-8 gene in colorectal carcinomas. Gastroenterology 2003: 125: 708-15. Lin Z, Kim H, Park H, Kim Y, Cheon J, Kim I. The expression of bcl-2 and bcl-6 protein in normal and malignant transitional epithelium. Urol Res 2003: 31: 272-5. Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nature Rev Cancer 2002: 2: 647-56. Cooke PW, James RG, Ganesan R, Burton A, Zoung LS, Wallace DMA. Bcl-2

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Association of Bax Expression and Bcl2/Bax Ratio with Clinical and Molecular Prognostic Markers in Chronic Lymphocytic Leukemia

Abbreviations: CLL, chronic lymphocytic leukemia Bcl2, B-cell lymphoma 2 Bax, Bcl2-associated X IGHV, immunoglobulin heavy chain variable region genes LPL, lipoprotein lipase mRNA, messenger ribonucleic acid miR, micro ribonucleic acid PBMC, peripheral blood mononuclear cells LDT, lymphocyte doubling time LDH, lactate dehydrogenase qRT-PCR, quantitative reverse-transcriptase polymerase chain reaction ROC, receiver operating characteristic A, area under the ROC curve CI, confidence interval References 1. Dighiero G. CLL

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Transcriptome analysis of ABCB1, ABCG2 and the BCL2/BAX ratio in refractory and relapsed canine lymphomas under treatment and rescue protocol

, Tait SW, Bouchier-Hayes L, Temirov J, McCormick LL, Dillon CP, Green DR: A unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell 2011,44:517-531. 14. Dettwiler M, Croci M, Vaughan L, Guscetti F: Immunohistochemical expression study of proapoptotic BH3-only protein bad in canine nonneoplastic tissues and canine lymphomas. Vet Pathol 2013,50:789-796. 15. Jung JT, Kim DH, Kwak EK, Kim JG, Park TI, Sohn SK, Do YR, Kwon KY, Song HS, Park EH, Lee KB: Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T

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Prognostic significance of p16, p53, Bcl-2, and Bax in oral and oropharyngeal squamous cell carcinoma

. Regulators of cell death. Trends Genet. 1995; 11:101-5. 5. Hall PA, Meek D, Lane DP. p53-integrating the complexity. J Pathol. 1996; 180:1-5. 6. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994; 9:1799-805. 7. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993; 366:704-7. 8. Mork J, Lie AK

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Telomerase Activity and MDS/EVI Gene Fusion in Myelodysplastic Syndrome. Correlation to the Immunohistochemical Expression of Ki-67, Bcl-2 and p53 in Bone Marrow Biopsy Samples

, Kawakubo K, Tauchi T, Ohyashiki K. Telomere dynamics in myelodysplastic syndrome determined by telomere measurement of marrow metaphases. Clin Cancer Res. 2003;9(4):1489-96. PMID:12684424 Hirai H. Molecular mechanisms of myelodysplastic syndrome. Jpn J Clin Oncol. 2003;33(4):153-60. doi:10.1093/jjco/hyg037 PMID:12810828 Davis RE, Greenberg PL. Bcl-2 expression by myeloid precursors in myelodysplastic syndromes: relation to disease progression. Leuk Res. 1998;22(9):767-77. doi:10.1016/S0145-2126(98)00051-4 PMID

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