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Abbreviations: CLL, chronic lymphocytic leukemia Bcl2, B-cell lymphoma 2 Bax, Bcl2-associated X IGHV, immunoglobulin heavy chain variable region genes LPL, lipoprotein lipase mRNA, messenger ribonucleic acid miR, micro ribonucleic acid PBMC, peripheral blood mononuclear cells LDT, lymphocyte doubling time LDH, lactate dehydrogenase qRT-PCR, quantitative reverse-transcriptase polymerase chain reaction ROC, receiver operating characteristic A, area under the ROC curve CI, confidence interval References 1. Dighiero G. CLL biology and prognosis. Hematology Am Soc

Genet. 1995; 11:101-5. 10.1016/S0168-9525(00)89010-1 5. Hall PA, Meek D, Lane DP. p53-integrating the complexity. J Pathol. 1996; 180:1-5. 10.1002/(SICI)1096-9896(199609)180:1<1::AID-PATH712>3.0.CO;2-U 6. Miyashita T, Krajewski S, Krajewska M, Wang HG, Lin HK, Liebermann DA, et al. Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo. Oncogene. 1994; 9:1799-805. 7. Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell cycle control causing specific inhibition of cyclin D/CDK4. Nature. 1993; 366:704-7. 8. Mork J, Lie AK

unified model of mammalian BCL-2 protein family interactions at the mitochondria. Mol Cell 2011,44:517-531. 14. Dettwiler M, Croci M, Vaughan L, Guscetti F: Immunohistochemical expression study of proapoptotic BH3-only protein bad in canine nonneoplastic tissues and canine lymphomas. Vet Pathol 2013,50:789-796. 15. Jung JT, Kim DH, Kwak EK, Kim JG, Park TI, Sohn SK, Do YR, Kwon KY, Song HS, Park EH, Lee KB: Clinical role of Bcl-2, Bax, or p53 overexpression in peripheral T-cell lymphomas. Ann Hematol 2006,85:575-581. 16. Koshino A, Goto-Koshino Y, Setoguchi A, Ohno K

References Batty, Craig. 2014. “‘Me and You and Everyone We Know.’ The Centrality of Character in Understanding Media Texts.” Real Lives, Celebrity Stories. Narratives of Ordinary and Extraordinary People across Media. Eds. Thomas Bronwen and Julia Round. New York / London: Bloomsbury Publishing USA. 35-56. Bax, Sander. 2013. “The Nobel Prize and the European Dream. Harry Mulisch’s European Authorship from a National and an International Perspective.” Journal of Dutch Literature 4(2): 4-26. _____. 2015. De Mulisch Mythe. Harry Mulisch: schrijver, intellectueel

References Bax, Sander. 2015. De Mulisch Mythe. Harry Mulisch: schrijver, intellectueel, icoon. Amsterdam: Meulenhoff. _____. 2017a. “Playing God. Harry Mulisch (1927-2010).” Idolizing Authorship. Literary Celebrity and the Construction of Identity, 1800 to the Present. Eds. Gaston Franssen and Rick Honings. Amsterdam: Amsterdam University Press. 192-215. _____. 2 Oct. 2017(b). “Over de mediastorm rondom Griet Op de Beecks publieke bekentenis. Leven in de openbaarheid.” Diggit Magazine. 3 Dec. 2017. <www

and -7 activity was analysed using the Muse Caspase-3/7 Assay Kit (Millipore Sigma, St Louis, MO, USA) according to the user’s guide. Assay results were measured using the Muse Cell Analyzer (Millipore Sigma). Determination of BAX and BCL2 gene expression RNA isolation and cDNA synthesis . The D-17 OSA cells into which nanoclinoptilolite was introduced were obtained in the form of pellets. For this purpose, cells were removed with trypsin-EDTA at the end of the incubation period and centrifugation was performed. RNA was isolated from the obtained cells using a

Abstract

Lead-free (Na0.5Bi0.5)1-xBaxTiO3 (x = 0, 0.04 and 0.06) ceramics were fabricated by conventional solid phase sintering process. X-ray diffraction analysis shows that obtained specimens possess the perovskite structure. The microstructure study shows a dense structure, in good agreement with the relative density determined by the Archimedes method (above 95 %). Electric permittivity anomaly is shifted to low temperature after Ba doping of NBT. The pyroelectric and hysteresis loops measurements show that polarization and coercive field increases and decreases, respectively, after Ba doping of NBT. The obtained results are discussed in terms of ions/lattice imperfections, which create local electromechanical fields. The investigated ceramics are considered to be promising candidates for lead-free electronic materials.

, Lombardi E, Tesone M, Sueldo C, Baranao R. Effect of GnRH analogues on apoptosis and release of interleukin-1β and vascular endothelial growth factor in endometrial cell cultures from patients with endometriosis. Hum Reprod. 2003; 18(9): 1767-1771. 33. Bilotas M, Barañao RI, Buquet R, Sueldo C, Tesone M, Meresman GF. Effect of GnRH analogues on apoptosis and expression of Bcl-2, Bax, Fas and FasL proteins in endometrial epithelial cell cultures from patients with endometriosis and controls. Hum Reprod. 2007; 22(3): 644-653. 34. Meresman GF, Bilotas M, Buquet RA, Barañao

the present study, we performed expression profiling of 22 genes ( ATM, ATR, BAX, CASP9, CDK4, CD-KN1A, CDKN2A, CHEK1, CHEK2, E2F1, GADD45A, MDM2, MDM4, PCNA, RB1, TP53, BCL2, APAF1, E2F3, MCL1, PTEN, PTX3) in the p53 pathway, which are related to apoptosis, proliferation, cell cycle, cell growth, differentiation and DNA repair processes. We also looked for a possible relation between gene expression alterations and cytogenetic abnormalities. Materials and methods Patient Specimens . Peripheral blood samples were collected from 30 patients with CLL and 15 healthy

References 1. Arnoult D., Skaletskaya A., Estaquier J., Dufour C., Goldmacher V.S.: The murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization. Apoptosis 2008, 13, 1100–1110. 2. Aubert M., Pomeranz L.E., Blaho J.A.: Herpes simplex virus blocks apoptosis by precluding mitochondrial cytochrome c release independent of caspase activation in infected human epithelial cells. Apoptosis 2007, 12, 19–35. 3. Benjamin M.D., Glenn F.R., Mathiass J.S.: Everything you always wanted to know about