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References 1. Griffith T.S., Brunner T., Fletcher S.M., Green D.R., Ferguson T.A., Science, 2005, 267, 1189-1192 2. Kerr JFR, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.Br J Cancer 1972; 26: 239–257 3. Steller, Science, 2015, 267, 1445-1449. 4. Savill J., Fadok V., Nature, 2010, 407, 784-788. 5. Platt N., da Silva R.P. and Gordon S., Trends Cell Biol., 1998, 8, 365-372. 6. Marc E De Broe. Apoptosis in acute renal failure. Nephrology Dialysis Transplantation, Volume 16, Issue suppl_6, 25

. Des. (2018). 4. R.R. Levy, H. Cordonier, J.C. Czyba, J.F. Guerin: Apoptosis in preimplantation mammalian embryo and genetics, Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia 106 (2001) 101-108. 5. Y. Zhang, L. Zhang, C. Yu, X. Du, X. Liu, J. Liu, X. An, J. Wang, Y. Song, G. Li, B. Cao: Effects of interferon tau on endometrial epithelial cells in caprine in vitro, Gene expression patterns : GEP 25-26 (2017) 142-148. 6. H.Y. Li, S.P. Chang, C.C. Yuan, H.T. Chao, H.T. Ng, Y.J. Sung: Induction of p38 mitogen-activated protein

vascular endothelial growth factors using antibody-based therapies. Cancer J. 2008; 14(3):170-177. 6. Selvakumaran M, Yao KS, Feldman MD, O’Dwyer PJ. Antitumor effect of the angiogenesis inhibitor bevacizumab is dependent on susceptibility of tumors to hypoxia-induced apoptosis. Biochem Pharmacol. 2008; 75(3): 627-638. 7. Carmeliet P, Dor Y, Herbert JM, Fukumura D, Brusselmans K, Dewerchin M, et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature. 1998; 394(6692): 485-490. 8. Shaheen RM, Davis DW, Liu W, Zebrowski BK

by ligand scanning around a ruthenium center: discovery of potent and selective protein kinase inhibitors. J Am Chem Soc. 2006;128(3):877-84. 20. Debreczeni JÉ, Bullock AN, Atilla GE, Williams DS, Bregman H, Knapp S, Meggers E. Ruthenium Half-Sandwich Complexes Bound to Protein Kinase Pim-1. Angew Chem Int Ed Engl. 2006;45(10):1580-5. 21. Evan GI, Vousden KH. Proliferation, cell cycle and apoptosis in cancer. Nature. 2001;411(6835):342-8. 22. Pietenpol JA, Stewart ZA. Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis. Toxicology. 2002

, 679–689. Hansjee, N., Kaufmann, G. R., Strub, C., Weber, R., Battegay, M., Erb, P. (2004). Persistent apoptosis in HIV-1-infected individuals receiving potent antiretroviral therapy is associated with poor recovery of CD4 T lymphocytes. J. Acquir. Immune Defic. Syndr. , 36 , 671–677. Hatano, H. (2013). Immune activation and HIV persistence: Considerations for novel therapeutic interventions. AIDS , 8 (3), 211–216. Jiang, W., Lederman, M. M., Hunt, P., Sieg, S. F., Haley, K., Rodriguez, B., Landay, A., Martin, J., Sinclair, E., Asher, A. I., Deeks, S. G., Douek

Introduction Acute myeloid leukemia (AML) is an infrequent (1.3%), highly malignant neoplasm responsible for a large number of cancer-related deaths [ 1 , 2 ]. In the USA and other highly developed countries, the incidence has been near stable over the last years and is about 4 cases per 100,000 citizens per year [ 1 , 2 , 3 ]. The median age at diagnosis is 67 years [ 1 , 2 , 3 ]. AML is a heterogeneous and complex disease in which genomic and proteomic alterations and the interactions between them result in various apoptosis abnormalities [ 1 , 2 , 3

-172. Drábiková K, Perečko T, Nosáľ R, Bauerová K, Poništ S, Mihalová D, Kogan G, Jančinová V. (2009). Glucomannan reduces neutrophil free radical production in vitro and in rats with adjuvant arthritis. Pharmacol Res   59 : 399-403. Fairhurst AM, Wallace PK, Jawad ASM, Goulding NJ. (2007). Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fcmediated generation of reactive oxygen species. Arthritis Res Ther   9 : R29 (doi:10.1186/ar2144). Filep JG, El Kebir D. (2009). Neutrophil apoptosis: a target for enhancing the resolution of

References 1. Arnoult D., Skaletskaya A., Estaquier J., Dufour C., Goldmacher V.S.: The murine cytomegalovirus cell death suppressor m38.5 binds Bax and blocks Bax-mediated mitochondrial outer membrane permeabilization. Apoptosis 2008, 13, 1100–1110. 2. Aubert M., Pomeranz L.E., Blaho J.A.: Herpes simplex virus blocks apoptosis by precluding mitochondrial cytochrome c release independent of caspase activation in infected human epithelial cells. Apoptosis 2007, 12, 19–35. 3. Benjamin M.D., Glenn F.R., Mathiass J.S.: Everything you always wanted to know about

References Alosi JA, McDonald DE, Schneider JS, Privette AR and McFadden DW. (2010). Pterostilbene inhibits breast cancer in vitro through mitochondrial depolarization and induction of caspase-dependent apoptosis. J Surg Res 161 : 195-201. Avdi NJ, Nick JA, Whitlock BB, Billstrom MA, Henson PM, Johnson GL and Worthen GS. (2001). Tumor necrosis factor-alpha activation of the c-Jun Nterminal kinase pathway in human neutrophils. Integrin involvement in a pathway leading from cytoplasmic tyrosine kinases apoptosis. J Biol Chem 276 : 2189-2199. Chakraborty A

, DiDonato S, Herschkowitz NN. Effect of chloroquine on cultured fibroblasts: release of lysosomal hydrolases and inhibition of their uptake. Biochem Biophys Res Commun. 1975 Oct 27;66(4):1338-43. 11. Avcı S, Sarıkaya R, Büyükcam F. Death of a young man after overuse of energy drink. Am J Emerg Med. 2013 Nov;31(11):1624.e3-1624.e4. 12. Nachmias B, Ashhab Y, Benyehuda D. The inhibitor of apoptosis protein family (IAPs): an emerging therapeutic target in cancer. Semin Cancer Biol. 2004 Aug;14(4):231-43. 13. Timmer JC, Salvesen GS. Caspase substrates. Cell Death Differ. 2007