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Modelling of absorption, distribution and physicochemical properties of AT1 receptor antagonists / Modelovanie absorpcie, distribúcie a fyzikálnochemických vlastnosti antagonistov AT1 receptorov

. Web-based calculation of molecular properties. Handbook of Chemoinformatics: From Data to Knowledge. Weinheim: Wiley-VCH; 2003, 1336-1348. [17] Frisch MJ, Trucks GW, Schlegel HB, et al. Gaussian, Inc., Wallingford CT, 2009. [18] Fukuhara M, Neves LA, Li P, Diz DI, Ferrario CM, Brosnihan KB. The angiotensin II AT1 receptor antagonist irbesartan prevents thromboxane A2-induced vasoconstriction in the rat hind-limb vascular bed in vivo. J Hypertens. 2001;19:561-566. [19] Hilal S, Karickhoff SW, Carreira LA

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Sex and salt intake dependent renin-angiotensin plasticity in the liver of the rat

. Iwai M, Horiuchi M. Devil and angel in the renin-angiotensin system: ACE-angiotensin II-AT1 receptor axis vs. ACE2-angiotensin-(1-7)-Mas receptor axis. Hypertens Res 32, 533–536, 2009. Kammerl MC, Richthammer W, Kurtz A, Kramer BK. Angiotensin II feedback is a regulator of renocortical renin, COX-2, and nNOS expression. Am J Physiol Regul Integr Comp Physiol 282, 1613–1617, 2002. Kobori H, Harrison-Bernard LM, Navar LG. Expression of angiotensinogen mRNA and protein in angiotensin II-dependent hypertension. J Am Soc Nephrol 12, 431–439, 2001

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Protective Effects of At1-Receptor Blocker and Ca Antagonist Combination on Renal Function in Salt Loaded Spontaneously Hypertensive Rats/ Протективни Ефекти На Комбинацијата На Ат1 Рецепторен Блокатор И Калциум Антагонист Врз Реналната Функција Кај Спонтано Хипертензивни Стаорци Оптоварени Со Сол

renal and cardiovascular protection. J Amer Soc Nephrol. 2004; 15: S64-S70. 5. Berl T. Angiotensin-converting enzyme inhibitors versus AT1 antagonist in cardiovascular and renal protection: the case for AT1 receptor antagonist. J Amer Soc Nephrol. 2004; 15: S71-S76. 6. Boffa J. Lu Y, Placier A, Stefanski A, Dussaule J, Chatziantoniou C. Reggression of renal and glomerular fibrosis: the rose of angiotensin IIreceptor antagonism andmatrix metalloproteinases. J Amer Soc Nephrol. 2003; 14: 1132-1144. 7. Trippodo N

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The effects of chronic losartan pretreatment on restraint stress-induced changes in motor activity, nociception and pentylenetetrazol generalized seizures in rats

References 1. Aguilera G, Kiss A, Luo X, Akbasak BS. The renin angiotensin system and the stress response. Ann NY Acad Sci 1995;771:173-86. 2. Saavedra JM, Ando A, Armando I, et al. Antistress and antianxiety effects of centrally acting angiotensin II At1 receptor antagonists. Regul Pept 2005;128:227-38. 3. Kiss A, Jurkovicova D, Jezova D, Krizanova O. Changes in angiotensin AT1 receptor mRNA levels in the rat brain after immobilization stress and inhibition of central nitric oxide synthase. Endocr Regul

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Alternative renin-angiotensin system pathways in adipose tissue and their role in the pathogenesis of obesity

, Alonso-Vale MI, Lima FB. Adipose tissue as an endocrine organ: from theory to practice. J Pediatr (Rio J) 83, S192–203, 2007. Fuentes P, Acuna MJ, Cifuentes M, Rojas CV. The anti-adipogenic effect of angiotensin II on human preadipose cells involves ERK1,2 activation and PPARG phosphorylation. J Endocrinol 206, 75–83, 2010. Fujimoto M, Masuzaki H, Tanaka T, Yasue S, Tomita T, Okazawa K, Fujikura J, Chusho H, Ebihara K, Hayashi T, Hosoda K, Nakao K. An angiotensin II AT1 receptor antagonist, telmisartan augments glucose uptake and GLUT4 protein expression in

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Effect of chronic treatment with angiotensin receptor ligands on water-salt balance in wistar and spontaneously hypertensive rats

the diurnal variations of nociception and motor coordination in rats. Peptides 2013;39:152-6. 10. Pechlivanova DM, Markova PP, Stoynev AG. Effect of the AT1 receptor antagonist losartan on diurnal variation in pain threshold in spontaneously hypertensive rats. Meth Find Exp Clin Pharmacol 2010;32(9):663-8. 11. Paxinos G, Watson C. The rat brain. 4th edition, Academic Press, Elsevier Science, 1998. 12. Pinto V, Pinho MJ, Silva E, et al. Long-term food restriction attenuates age-related changes in the expression of renal

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An alternative synthesis of Azilsartan: an angiotensin II receptor blocker

References 1. Aulakh G.K., Sodhi R. K., Singh M.: An update on non-peptide angiotensin receptor antagonists and related RAAS modulators. J. Life Sci. 2007, 81, 615-639. 2. Miura S., Karnik S. S., Saku K.: Ability of the new AT1 receptor blocker azilsartan to block angiotensin II-induced AT1 receptor activation after wash-out. J Renin Angiotensin Aldosterone Syst. 2011, 12, 1-7. 3. Naka T. K., Inada. Y.: Compound which is an angiotensin antagonist. U.S.Patent No.5,243,054. 4. Kuroita T., Sakamoto

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Rosmarinus Improved Skin Flap Survival Through mTOR Dependent Pathway

References 1. Lin R, Chen H, Callow D, Li S, Wang L, Li S, et al. Multifaceted effects of astragaloside IV on promotion of random pattern skin flap survival in rats. Am J Transl Res. 2017;9(9):4161-72. 2. Zhou KL, Zhang YH, Lin DS, Tao XY, Xu HZ. Effects of calcitriol on random skin flap survival in rats. Sci Rep. 2016;6:18945. 3. Pazoki-Toroudi HR, Hesami A, Vahidi S, Sahebjam F, Seifi B, Djahanguiri B. The preventive effect of captopril or enalapril on reperfusion injury of the kidney of rats is independent of angiotensin II AT1 receptors

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AGT A-20C (rs5050) gene polymorphism and ulcer occurrence in patients treated with low-dose aspirin: a case-control study / Polimorfismul AGT A-20C și ulcerele gastro-duodenale la pacienții sub tratament cu aspirină în doze antiagregante: studiu caz-control

-inflammatory effects of angiotensin II AT1 receptor antagonism prevent stress-induced gastric injury. Am J Physiol Gastrointest Liver Physiol. 2003;285(2):G414-23. DOI: 10.1152/ajpgi.00058.2003 17. Bregonzio C, Armando I, Ando H, Jezova M, Baiardi G, Saavedra M. Angiotensin II AT1 receptor blockade prevents gastric ulcers during cold-restraint stress. Ann N Y Acad Sci. 2004;1018:351-5. DOI: 10.1196/annals. 1296.044 18. Carl-McGrath S, Grantzdorffer I, Lendeckel U, Ebert MP, Rocken C. Angiotensin II-generating enzymes, angiotensin-converting enzyme

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Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats

hypertensive rats. Role of cytochrome P 450 3A. Hypertension   24 : 480-485. Bump EA, Yvonne C,. Taylor and Brown JM. (1983) Role of glutathione in the hypoxic cell cytotoxicity of misonidazole. Cancer Res   43 : 997-1002. Cediel E, Sanz-Rosa D, Oubina MP, de las Heras N,. Gonzales Fr, Vegazo O, Jimenez J, Cachfeiro V and Lahera V. (2003) Effect of AT1 receptor blockade on hepatic redox status in SHR: possible relevance for endothelial function? AJP-Regul Integr Comp Physiol   285 : 674

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