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Flozins, inhibitors of type 2 renal sodium-glucose co-transporter – not only antihyperglycemic drugs

References 1. Bhatia K. et al.: Canagliflozin-current status in the treatment of type 2 diabetes mellitus with focus on clinical trial data. World J. Diabetes, 5, 399, 2014. 2. Chao E., Henry R.: SGLT2 inhibition - a novel strategy for diabetes treatment. Nature Rev. Drug Discov., 9, 551, 2010. 3. Diamant M., Morsink L.: SGLT2 inhibitors for diabetes: turning symptoms into therapy. Lancet, 382, 917, 2013. 4. Endocrine Today.

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The blood resistin level in patients with DM2, depending on the duration of the disease

; 409: 307-12. 17. Tokuyama Y. et al.: Serum resistin level is associated with insulin sensitivity in Japanese patients with type 2 diabetes mellitus. Metabolism, 2007; 56 (5): 693-698. 18. Vozarova De Courten B. et al.: High serum resistin is associated with an increase in adiposity but not worsening of insulin resistance in Pima Indian. Diabetes, 2004; 53 (9): 1279-1284.

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Novel pentacyclic triterpene isolated from seeds of Euryale Ferox Salisb. ameliorates diabetes in streptozotocin induced diabetic rats

). Effect of Vaccinium bracteatum Thunb. leaves extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice. J. Ethnopharm. 130 : 465–9. Yoon KH, Ko SH, Cho JH, Lee JM, Ahn YB, Song KH, Yoo SJ, Kang MI. (2003). Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. The Journal of Clinical Endocrinology & Metabolism. 88 : 2300–2308. Zhang XF, Tan BK. (2000). Anti-hyperglycemic and antioxidant properties of Andrographis paniculata in normal and diabetic rats. Clin. Exp. Pharmacol

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Diabetic nephropathy in type 2 diabetes – from pathological mechanisms to clinical occupational medicine practice

diabetic kidney disease: state of the art and future perspective. Kidney Int Suppl 2011;8:2-7. 21. Viberti GC, Hill RD, Jarrett RJ, Argyropoulos A, Mahmud U, Keen H. Microalbuminuria as a predictor of clinical nephropathy in insulin-dependent diabetes mellitus. Lancet. 1982;1:1430–2. 22. Bosman DR, Winkler AS, Marsden JT, Macdougall IC, Watkins PJ. Anemia with erythropoietin deficiency occurs early in diabetic nephropathy. Diabetes Care 2001;24:495-9. 23. Chokhandre MK, Mahmoud MI, Hakami T, Jafer M, Inamdar AS. Vitamin D & its analogues in type 2

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Hypolipidemic, hepatoprotective, nephroprotective and anti-lipid peroxidation properties of a methanol extract of Paullinia pinnata root-bark, in alloxan-induced hyperglycemic rats

Reference 1. Ajiboye BO, Oloyede HOB, Salawu MO. Antihyperglycemic and antidyslipidemic activity of Musa paradisiaca – based diet in alloxan-induced diabetic rats. Food Sci Nutr. 2018;6:137-45. 2. Chen L, Magliano DJ, Zimmet PZ. The worldwide epidemiology of type 2 diabetes mellitus – present and future perspectives. Nat Rev Endocrinol. 2012;8:228-36. 3. Matsuda M, Shimomura I. Increased oxidative stress in obesity: implications for metabolic syndrome, diabetes

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Monotherapy of experimental metabolic syndrome: I. Efficacy and safety

natural history of the metabolic vascular syndrome and its coincidence with Type 2 diabetes mellitus and cardiovascular diseases in different european countries. Metab Res. doi: 10.1055/s-0043-122395. [Epub ahead of print]PMID:29183091) ]. Liao JK. (2002). Beyond lipid lowering: The role of statins in vascular protection. Int J Cardiol 86 : 5–18. Mendrick DL, Diehl AM, Topor LS, Dietert RR, Will Y, La Merrill MA, Bouret S, Varma V, Hastings KL, Schug TT, Emeigh Hart SG, Burleson FG. (2017). Metabolic syndrome and associated diseases: From the bench to

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Protection of the vascular endothelium in experimental situations

cells. J Biol Chem   271 : 15146-15152. Vanhoutte PM and Mombouli JV. (1996). Vascular endothelium: vasoactive mediators. Prog Cardiovasc Dis   39 : 229-238. Waters PJ, Flyn MD, Corrall RJM and Pennock CA. (1992). Increases in plasma lysosomal enzymes in type 1 (insulin-dependent) diabetes mellitus: relationship to diabetic complications and glycaemic control. Diabetologia   35 : 991-995. Wendt MC, Daider A, Kleschyov AL, Mülch A, Sydow K, Schulz E, Chen K, Keaney JF, Lassegue B, Walter U

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Co-morditities of environmental diseases: A common cause

stolen future. Penguin Books, New York. Colosia AD, Palencia R, Khan S. (2013). Prevalence of hypertension and obesity in patients with type 2 diabetes mellitus in observational studies: a systematic literature review. Diabetes Metal Syndr Obes 6: 327-38. Cordu N, Schymura MJ, Nogotia S, Rej R, Carpenter DO. (2007). Diabetes in relation to serum levels of polychlorinated biphenyls and chlorinated pesticides in adult native Americans. Environ Health Perspect 115(10): 1442-47. Crespi B. (2011). Autism and cancer risk

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Protective efficacy of folic acid and vitamin B12 against nicotine-induced toxicity in pancreatic islets of the rat

Biol Med 50(5) : 567–575. Raso GM, Meli R, Gualillo O, Pacilio M, Carlo RD. (1999). Prolactin induction of nitric oxide synthase in rat C6 Glioma cells. J Neurochem 73 : 2272–2277. Reis RP, Azinheira J, Reis HP, Pina JE, Correia J M, Luis AS. (2000). Influence of smoking on homocysteinemia at baseline and after methionine load. Rev Port Cardiol l19 : 471–474. Robertson R, Zhou H, Zhang T, Harmon J. (2007). Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes. Cell Biochem Biophys 48 : 139

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Antioxidant SMe1EC2 modulates pentose phosphate pathway and glutathione-dependent enzyme activities in tissues of aged diabetic rats

from oxidative damage and improves healthspan in mice. Nat Commun 7: 10894. Ozdemir S, Tandogan B, Ulusu NN, Turan B. (2009). Angiotensin II receptor blockage prevents diabetes-induced oxidative damage in rat heart. Folia Biol (Praha) 55: 11-16. Pahwa S, Sharma R, Singh B. (2017). Role of Glutathione S-Transferase in Coronary Artery Disease Patients with and Without Type 2 Diabetes Mellitus. J Clin Diagn Res 11: BC05-BC08. Panigrahy SK, Bhatt R, Kumar A. (2017). Reactive oxygen species: sources, consequences and

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