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Iwona Strzelecka, Joanna Płużańska, Jerzy Węgrzynowski, Tomasz Moszura, Maciej Słodki and Maria Respondek-Liberska


Most heart defects form between 4 and 6 weeks after fertilization. The detection rate is still growing. Despite significant progress in prenatal diagnosis some cases still go undetected. We present two cases of similar defects: prenatally detected and undetected, both presenting with a normal four chamber view in mid-pregnancy. We compared the follow-up of both neonates along with sustained health and economic consequences. The dynamics of the development of heart defects during prenatal life suggests the legitimacy to perform additional, late echocardiography exams (35-38 weeks of gestation)

Open access

Iwona Strzelecka, Maria Respondek-Liberska, Maciej Słodki, Katarzyna Zych-Krekora and Bettina Cuneo

Treat or to Observe? Ginekol Pol. 2010, 81(2),135-139 12. Sokol V, Juras J, Malćić, Blajić J, Ivaniśević M. Digoxin and Amiodaron in fetal sustained supraventriclar tachycardia and nonimmune hydrops. Gynaecol Perinatal. 2011, 20 (1),44-47 13. Jaeggi E.T, Carvalho J.S, De Groot E, Api O, Clur S.B, Rammeloo L, McCrindle B.W, Ryan G, Manlhiot C, Blom N.A. Comparison of Transplacental Treatment of Fetal Supraventricular Tachyarrhythmias With Digoxin, Flecainide, and Sotalol. Circulation. 2011, 124, 1747-1754 14. Hirose A

Open access

Paulo Zielinsky

/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. Circulation 2007, 115 (13): 1777-88 55. Vogel M, Reversible ductus arteriosus constriction due to maternal indomethacin after fetal intervention for hypoplastic left heart syndrome with intact/restrictive atrial septum. Fetal Diagnosis and Therapy 2011, 27: 40-45 56. Moise KJ, Jr, et al.: Placental transfer of indomethacin