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A.H. Khoshab, P. Dumy and B. Kolarovszkl

Abstract

A prospective multicentral observational study of minimally invasive fusion to treat degenerative lumbar disorders, and to report outcomes of one or two level minimally invasive posterior lumbar interbody fusion (MLIF) for degenerative lumbar disorders in a multi-center 1-year prospective study. We prospectively studied a group of 32 patients, mostly female 24 ( 75% female ), and 8 males ( 25%). They underwent minimally invasive transforaminal lumbar interbody fusion (mTLIF), 21 of them monosegmental and 11 bisegmental. Patients demographics, intraoperative data and complications were recorded. Time to first ambulation, time to study-defined recovery, surgical duration, blood loss, fluoroscopy time and adverse events were recorded. Visual analogue scale (VAS) of back and legs pain, Oswestry disability index (ODI) and health-related questionnaire (EQ-5D) were assessed preoperatively and at defined time points through 12 months postoperatively. Mean surgical duration, blood loss and intraoperative fluoroscopy time were 125 vs.175 minutes, 150 vs. 170 ml, and 105 vs. 145 seconds in one- and twolevel segments, respectively. Mean preoperative VAS back (6.5) and VAS leg (7.9) scores dropped significantly (p<0.0001) to 3.5 (2.6) and 2.1 (2.0) at discharge (6 weeks). At the end, this is the largest prospective multi-center observational study of MLIF to date, following routine local standard of practice and, MLIF demonstrated favourable clinical results with early and sustained improvement in patient reported outcomes and low major perioperative morbidity.

Open access

I. Tonhajzerova, I. Ondrejka, K. Javorka, A. Calkovska and M. Javorka

-78. Tonhajzerova I, Ondrejka I, Adamik P, Hruby R, Javorka M, Trunkvalterova Z, Mokra D, Javorka K. Changes in the cardiac autonomic regulation in children with attention deficit hyperactivity disorder (ADHD). Ind J Med Res 2009; 130: 44-50. Henry BL, Minassian A, Paulus MP, Geyer MA, Perry W. Heart rate variability in bipolar mania and schizophrenia. J Psychiatr Res 2010; 44: 168-76. Börger N, van der Meere J, Ronner A, Alberts E, Geuze R, Bogte H. Heart rate variability and sustained attention in ADHD children - attention

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K. Javorka, M. Javorka, I. Tonhajzerova, A. Calkovska, Z. Lehotska, Z. Bukovinska and M. Zibolen

prediction to developmental outcomes in early childhood. Child Dev 2007; 78(6): 1788-1798. Thomas PW, Haslum MN, MacGillivray I, Golding MJ. Does fetal heart rate predict subsequent heart rate in childhood? Early Hum Develop 1989; 19:147-152. Feldman R. From biological rhythms to social rhythms: Physiological precursors of mother-infant synchrony. Devel Psychol 2006; 42:175-188. Richards JE. Development and stability in visual sustained attention in 14, 20, and 26 week infants. Psychophysiol 1989

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I Bujnakova, I Ondrejka, M Mestanik, D Fleskova, N Sekaninova, I Farsky and I Tonhajzerova

cardiac sympathovagal control in attention deficit/hyperactivity disorder (ADHD)? Can J Physiol Pharmacol 2016; 94(6): 579-87. 54) Griffiths KR, Quintana DS, Hermens DF, Spooner C, Tsang TW, Clarke S et al . Sustained attention and heart rate variability in children and adolescents with ADHD. Biol Psychol 2017; 124: 11-20.

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Astrid Hendriks and Tamás Szili-Török

/American Heart Association Task Force and the European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol. 2006;48:e247–346. 8. Nogami A. Purkinje-related arrhythmias part II: polymorphic ventricular tachycardia and ventricular fibrillation. Pacing Clin Electrophysiol. 2011 Aug;34(8):1034-49. 9. Hayashi M, Miyauchi Y, Murata H, et al. Urgent catheter ablation for sustained ventricular tachyarrhythmias

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Ayman Geddawy, Yasmine F. Ibrahim, Nabil M. Elbahie and Mohammad A. Ibrahim

patients, with or without RBV in phase 2 trials. Moreover, it provides better sustained virological response in relapsing cases from RBV/SOF combination. [17] While it is only currently available as a combination with Sof. Ledipasvir several studies have shown its value as a combination therapy with other DAA therapies, other than SOF. [18] The current recommendation for LDV use suggests there is no need to combine LDV/ SOF with RBV or to prolong the treatment duration for more than 12 weeks. [19] Moreover, a more recent study recommends that a patient with HCV RNA

Open access

Diana Opincariu, Szilamér Korodi and Annabell Benedek

;7:79-108. doi: 10.1016/j.euje.2005.12.014. 24. Pedersen CT, Kay GN, Kalman J, et al. ESC Scientific Document Group; EHRA/HRS/APHRS expert consensus on ventricular arrhythmias. EP Europace. 2014;16:1257-1283. doi: https://doi.org/10.1093/europace/euu194. 25. Katritsis DG, Camm AJ. Nonsustained ventricular tachycardia: where do we stand? Eur Heart J. 2004;15:1093-1099. doi: 10.15420/aer.2016:5.3.GL1. 26. Hadid C. Sustained ventricular tachycardia in structural heart disease. Cardiol J. 2015;22:12-24. doi: 10.5603/CJ.a2014

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Romeo-Gabriel Mihăilă

Hepatitis C With Moderate or Severe Liver Disease: A Cohort Study . Clin Infect Dis 2017; 65 :235-43. [48] FACCIORUSSO A., DEL PRETE V., TURCO A., BUCCINO R.V., NACCHIERO M.C., MUSCATIELLO N. Long-term liver stiffness assessment in HCV patients undergoing antiviral therapy: Results from a 5-year cohort study. J Gastroenterol Hepatol 2018; 33 :942-9. [49] CHEN YI MEI S.L.G., THOMPSON A.J., CHRISTENSEN B., CUNNINGHAM G., MCDONALD L., et al. Sustained virological response halts fibrosis progression: A long-term follow-up study of people with chronic hepatitis

Open access

Paula Ionilă, Ruxandra Jurcuţ, Nicoleta Ferariu, Monica Roşca, Monica Chivulescu, Adriana Mursă, Sebastian Militaru, Alin A. Ionescu, Cristina Căldăraru, Ana G. Fruntelată, Silvia F. Goanţă, Simina Crişan, Adina Ionac, Ana-Maria Avram, Attila Frigy, Radu Sascău, Cătălina Arsenescu-Georgescu, Ioan M. Coman, Bogdan A. Popescu, Carmen Ginghină and Eduard Apetrei

., GIMENO JR., SHARMA S., PENAS-LADO M., MCKENNA WJ. Non-sustained ventricular tachycardia in hypertrophic cardiomyopathy . J Am Coll Cardiol. 2003; 42 (5):873-9. 13. ADABAG AS., CASEY SA., KUSKOWSKI MA., ZENOVICH AG., MARON BJ. Spectrum and prognostic significance of arrhythmias on ambulatory Holter electrocardiogram in hypertrophic cardiomyopathy . J Am Col. Cardiol. 2005; 45 (5):697-704. 14. MARON MS, OLIVOTTO I, ZENOVICH AG, LINK MS, PANDIAN NG, KUVIN JT, et al. Hypertrophic cardiomyopathy is predominantly a disease of left ventricular outflow tract

Open access

Andrada-Loredana Popescu, Florentina Ioniţa-Radu, Mariana Jinga, Andrei-Ionuţ Gavrilă, Florin-Alexandru Săvulescu and Carmen Fierbinţeanu-Braticevici

Abstract

The prevalence of obesity is rising, becoming a medical problem worldwide. Also GERD incidence is higher in obese patients compared with normal weight, with an increased risk of 2.5 of developing symptoms and erosive esophagitis. Different treatment modalities have been proposed to treat obese patients, but bariatric surgery due to its complex interactions via anatomic, physiologic and neurohormonal changes achieved the best long-term results, with sustained weight loss and decrease of complications and mortality caused by obesity. The bariatric surgical procedures can be restrictive: laparoscopic adjustable gastric band (LAGB) and laparoscopic sleeve gastrectomy (LSG), or malabsorptive-restrictive such as Roux-en-Y gastric bypass (RYGB). These surgical procedures may influence esophageal motility and lead to esophageal complications like gastroesophageal reflux disease (GERD) and erosive esophagitis. From the literature we know that the RYGB can ameliorate GERD symptoms, and some bariatric procedures were finally converted to RYGB because of refractory reflux symptoms. For LAGB the results are good at the beginning, but some patients experienced new reflux symptoms in the follow-up period. Recently LSG has become more popular than other complex bariatric procedures, but some follow-up studies report a high risk of GERD after it. This article reviews the results published after LSG regarding gastroesophageal reflux and the mechanisms responsible for GERD in morbidly obese subjects.