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Molecular Pathogenesis of Liver Steatosis Induced by Hepatitis C Virus

References 1. Chang ML, Yeh HC, Tsou YK, Wang CJ, Cheng HY, Sung CM, et al. HCV core-induced nonobese hepatic steatosis is associated with hypoadiponectinemia and is ameliorated by adiponectin administration. Obesity (Silver Spring) 2012; doi: 10.1038/ oby.2012.45. 2. Sato S, Fukasawa M, Yamakawa Y, Natsume T, Suzuki T, Shoji I, et al. Proteomic profiling of lipid droplet proteins in hepatoma cell lines expressing hepatitis C virus core protein. J Biochem 2006;139:921-930. 3. Congiu M, Ryan MC, Desmond PV. No

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Pathological Alterations in Hepatocytes of Dairy Cows With a Tendency to Emaciation and Fattening

. Li, M., Song, J., Mirkov, S., Xiao, S. Y., Hart, J., Liu, W., 2011: Comparing morphometric, biochemical and visual measurements of macrovesicular steatosis of liver. Hum. Pathol., 42, 356-360. 18. Mak, K. M., Kwong, A. J., Chu, E., Hoo, N. M., 2012: Hepatic steatosis, fibrosis and cancer in elderly cadavers. Anat. Rec., 295, 40-50. 19. Makovicky, P., Dudova, M., Tumova, E., Rajmon, R., Vodkova, Z., 2011: Experimental study of non-alcoholic fatty liver disease (NAFLD) on a model of starving chickens: is generalization of steatosis

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Influence of Non-Oxidised and Oxidised Rapeseed Oil Consumption on Liver Metabolism Pathways and Non-Alcoholic Steatohepatitis Development in Rabbits

References 1. Bandsma R.H., Wiegman C.H., Herling A.W., Burger H.J., ter Harmsel A., Meijer A.J., Romjin J.A., Reijngoud D.J., Kuipers F.: Acute inhibition of glucose- 6-phoshpate translocator acitvity leads to increase de novo lipogenesis and development of hepatic steatosis without VLDL production in rats. Diabetes 2001, 50, 2591-2597. 2. Champe P.C., Harvey R.A.: Biochemistry, Philadelphia, USA, 1994. 3. Choe E., Min D.B.: Chemistry of deep-fat frying oils. J Food Sci 2007, 72 77

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Hepatic fibrosis, measured by fibroscan in a group of patients with obesity


Introduction.Hepatic steatosis is a reversible condition caused by accumulation of triglycerides in liver cells. Non-alcoholic fatty liver disease (NAFLD) can progress to advanced liver disease: fibrosis, cirrhosis, liver failure, cancer, and finally can lead to death; therefore NAFLD contributes significantly to morbidity and mortality of hepatic cause. Materials and methods: The study was conducted on a group of 88 patients with Body Mass Index (BMI) ≥ 30kg/m², they were excluded patients with known diabetes. Results, Discussion: The statistical analysis showed that in more than half of subjects elastometry values were higher than those considered normal, obesity is a risk factor for NAFLD that progresses in hepatic fibrosis. Conclusions: Liver fibrosis is present in high percentage in patients with obesity (52% of subjects) and it was positively correlated with age, arterial stiffness and fasting glucose.

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Pharmacokinetics of Doxycycline in Ducks with Steatosis due to Force-feeding

-Maximilians-Universitet, München, Germany, 9. Bernard, P.G., Bengone, T, Prehn, D., Durand, S., Labie, C., Benard, P. (2006). Physiology of ducks during force-feeding: study of hepatic steatosis. Bulletin de l‘Academie Vétérinaire de France 159, 43–54. 10. Bogin, E., Avidar, Y., Merom, M., Israeli, B., Malkinson, M., Sobak, S., Kudler, Y. (1984). Biochemical changes associated whit fatty liver in geese. Avian Pathol. 13, 683-901. PMid:18766879 11. Awde, S., Marty-Gasset, N., Wilkesman, J., Remingnon, H. (2013). Proteolytic activity

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Pentoxifylline with metformin treatment improves biochemical parameters in patients with nonalcoholic steatohepatitis

currently investigated in clinical trials, including obeticholic acid, liraglutide, elafibranor, and aramchol are being evaluated ( 10 ). Lifestyle modification focused on diet and exercises continue to be the primary treatment ( 11 ). The American Association for the Study of Liver Diseases practice guideline suggests the loss of at least 3–5% of body weight to improve steatosis, and up to 10% to improve necroinflammation ( 12 ). However, most patients who ask medical advice have a long history of ineffective attempts at dietary and lifestyle changes ( 13 ). Furthermore

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The pathogenesis of non-alcoholic fatty liver disease is closely related to the metabolic syndrome components

, atherosclerosis, and aspects of insulin action. Diabetes Care 28: 2312-2319, 2005. 18. Targher G, Bertolini L, Scala L et al . Nonalcoholic hepatic steatosis and its relation to increased plasma biomarkers of inflammation and endothelial dysfunction in nondiabetic men. Role of visceral adipose tissue. Diabet Med 22: 1354-1358, 2005. 19. Savage DB, Petersen KF, Shulman GI . Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev 87: 507-520, 2007. 20. Cnop M, Landchild MJ, Vidal J et al. The

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Epidemiology and Natural History of Nafld/Epidemiologija I Prirodna Istorija Nealkoholne Masne Jetre

adults: A systematic review. J Hepatol 2011; 56: 255-66. 7. Socha P, Horvath A, Vajro P, Dziechciarz P, Dhawan A, Szajewska H. Pharmacological interventions for nonalcoholic fatty liver disease in adults and in children: a systematic review. J Pediatr Gastroenterol Nutr 2009; 48: 587-96. 8. Bellentani S, Scaglioni F, Marino M, Bedogni G. Epide - miology of Fatty Liver Disease. Dig Dis 2010; 28: 155-61. 9. Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in

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Metabolic disorders and cardiovascular risk enhanced by nonalcoholic fatty liver disease in patients with metabolic syndrom

References 1. Angulo P . Nonalcoholic Fatty Liver Disease. The New England Journal of Medicine Vol. 346, No. 16: 1221-1231, 2002. 2. Festi D, Colecchia A, Sacco T, Bondi M, Roda E and Marchesini G. Hepatic steatosis in obese patients: clinical aspects and prognostic significance. Obesity reviews 5: 27-42, 2004. 3. Farrell GC, Larter CZ. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology 43(2 Suppl 1): S99-S112, 2006. 4. Szczepaniak LS, Nurenberg P, Leonard D

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Influence of α-lipoic acid on morphology of organs of rabbits fed a high fat diet with the addition of oxidised rapeseed oil

References 1. Berliner J.A., Heinecke W.J.: The role of oxidized lipoproteins in atherogenesis. Free Radic Biol Med 1996, 20, 707–727. 2. Brukow K.G.: Oxidized lipids: The two faces of vascular inflammation. Curr Atheroscler Rep 2006, 8, 223–231. 3. Bukol-Krawczyk K.: Nonalcoholic steatosis of the liver – to treat or not to treat? Forum Metabol Disord 2010, 1, 66–72. 4. Choe E., Min D.B.: Chemistry of deep-fat frying oils. J Food Sci 2007, 72, 77–86. 5. Cohn J.: Oxidized fat in the diet, postprandial lipaemia and cardiovascular

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