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Uros Smrdel, Marija Skoblar Vidmar and Ales Smrdel

on survival might be achieved with less aggressive approach. 15 , 16 The results of these studies had proven that in elderly, the same survival benefit might be achieved solely with the chemotherapy using temozolomide. The effect of temozolomide is primarily marked in patients, which have methylated methylguaninem-ethyltransferase (MGMT) promoter region, thus disabling the tumour cells to repair the alkylation of tumour DNA. In Slovenia, we are also noting the increase of the number of elderly glioblastoma patients. 5 , 6 Our strategy so far has been to assign