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Yu Yen Ee and Chew Choy Hoong

:760-85. 4. Gerbod-Giannone M, Li Y, Holleboom A, Han S, Hsu L, Tabas I, et al. TNF-α induces ABCA1 through NF-κB in macrophages and in phagocytes ingesting apoptotic cells. Proc Natl Acad Sci U S A. 2006; 103:3112-7. 5. Tacer KF, Kuzman D, Seliskar M, Pompon D, Rozman D. TNF-α interferes with lipid homeostasis and activates acute and proatherogenic processes. Physiol Genomics. 2007; 31:216-27. 6. Kwon SH, Nam JI, Kim SH, Kim JH, Yoon JH, Kim KS. Kaempferol and quercetin, essential ingredients in ginkgo biloba extract, inhibit interleukin-1β

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Thassanee Vongnam, Supeecha Wittayalertpanya, Nijsiri Raungrungsi and Wacharee Limpanasithikul

Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand. 9. Mahidol C, Prawat H, Prachyawarakorn V, Ruchirawat S. Investigation of some bioactive Thai medicinal plants. Phytochemistry. 2002; 1:287-97. 10. Formica JV, Regelson W. Review of the Biology of Quercetin and Related Bioflavonoids. Food Chem Toxicol. 1995; 33:1061-80. 11. Amano F, Noda T. Improved detection of nitric oxide radical (NO) production in an activated macrophage culture with a radical scavenger, carboxy PTIO, and Griess reagent. FEBS letters. 1995

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Wanmai Moleephan, Supeecha Wittayalertpanya, Nijsiri Ruangrungsi and Wacharee Limpanasithikul

:94-7. 34. Jacobsohn GM, Chiartas PL, Hearing VJ, Jacobsohn MK. Role of estradiol and 2-hydroxyestradiol in melanin formation in vitro. Biochim Biophys Acta Gen Subj. 1988; 966:222-30. 35. Martin S. Influence of the polyunsaturated fatty acids linoleic acid, arachidonic acid, [alpha]-linolenic acid and [gamma]-linolenic acid on melanogenesis of B16 mouse melanoma cells and normal human melanocytes [PhD Thesis]: University of Basel; 2002. 36. Takeyama R, Takekoshi S, Nagata H, Osamura RY, Kawana S. Quercetin-induced melanogenesis in a

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Çağri Öner, Ertuğrul Çolak and Didem Turgut Coşan

but is more potent for Kv1.3 and Kv1.6 channels [ 18 ]. Although astemizole (AST) targets ATP-binding cassette transporters and histamine receptors, as well as binding to chromatin, it also inhibits several VGPCs, especially Eag-related gene ( Erg ) [ 19 ]. The synergistic effect of TEA and quercetin, an antioxidant and anticancer drug, inhibited the overexpression of K Ca in and proliferation of bladder cancer cells [ 20 ]. The proliferation of breast cancer cells was inhibited by using TEA to block Kv1.3 channels [ 21 ]. 4-AP inhibits both proliferation of