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Junyu Liang, Weiqian Chen and Jin Lin

-regulation of MALAT1 is seen in various human cancers and has been proven to be associated with cancer metastasis and recurrence. [ 55 ] Pan et al . observed theelevation of apoptotic rate of RA FLSs after the treatment of quercetin. [ 56 ] To figure out the molecular mechanism of the effect of quercetin on RA FLSs, alterations of expression of lncRNAs within the cells were analyzed with the application of PCR array and qPCR. And MALAT1 was found to be the most prominently altered lncRNA in RA FLSs. The knockdown of MALAT1 inhibited the apoptosis of the RA FLSs, decreased