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Comparative Study Of The Protective Effect Of Aronia Melanocarpa Fruit Juice And Quercetin In A Model Of Paracetamol-Induced Hepatotoxicity In Rats

References 1. McConnachie LA, Mohar I, Hudson FN, Ware CB, Ladiges WC, Fernandez C Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice. Toxicol Sci. 2007;99(2):628-36. 2. Jaeschke H, Knight TR, Bajt ML. The role of oxidant stress and reactive nitrogen species in acetaminophen hepatotoxicity. Toxicol Lett. 2003;144(3):279-88. 3. Yousef MI, Omar SA, El-Guendi MI, Abdelmegid LA. Potential protective effects of quercetin and curcumin on paracetamol

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The Effects of Satureja hortensis L. Extract on Cisplatin-induced Behavioral Alterations in the Tail Suspension Test

. Almaghrabi OA. (2015). Molecular and biochemical investigations on the effect of quercetin on oxidative stress induced by cisplatin in rat kidney. Saudi J Biol Sci, 22(2), 227–31. 20. Yuce A, Atessahin A, Ceribasi AO, Aksakal M. (2007). Ellagic acid prevents cisplatin-induced oxidative stress in liver and heart tissue of rats. Basic Clin Pharmacol Toxicol, 101(5), 345-9. 21. Noori S, Mahboob T. (2010). Antioxidant effect of carnosine pretreatment on cisplatin-induced renal oxidative stress in rats. Indian Clin Biochem, 25(1), 86-91. 22. Moon JH, Shin JS

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Influence of Platelet Aggregation Modulators on Cyclic AMP Production in Human Thrombocytes

inhibition spares actin assembly in activating platelets but reverses platelet aggregation. J Biol Chem 1995;270(19):11358-66. 8. Oh WJ, Endale M, Park SC, et al. Dual roles of quercetin in platelets: phosphoinositide-3-kinase and MAP kinases inhibition, and cAMP-dependent vasodilator-stimulated phosphoprotein stimulation. Evid Based Complement Alternat Med 2012;2012:485262. 9. Siffert W, Gengenbach S, Scheid P. Inhibition of platelet aggregation by amiloride. Thromb Res 1986;44(2):235-40. 10. Lees AD, Wilson J, Orchard CH, et al. Ouabain enhances basal

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The Influence of Mg(II) and Ca(II) Ions on Rutin Autoxidation in Weakly Alkaline Aqueous Solutions

formation in enzymic and chemical oxidation of quercetin and related flavonols. Food Chem 2002; 77: 177-185. 12. Savic S, Vojinovic K, Milenkovic S, Smelcerovic A, Lamshoeft M, Petronijevic Z et al.. Enzymatic oxidation of rutin by horseradish peroxidase: Kinetic mechanism and identification of a dimeric product by LC-Orbitrap mass spectrometry. Food Chem 2013; 141: 4194-4199. 13. Tournaire C, Hocquaux M, Beck I, Oliveros E, Maurette M-T et al

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Antioxidant Activity of Dry Birch (Betula Pendula) Leaves Extract

triterpene products from different parts of birch, Betula pendula , Roth. JPS 2013;2(2):1-10. 5. Dimitrova S, Andonova V, Peneva P, et al. [Determination of biologically active substances in Folia Betulae extracts.] Research proceedings of Paisiy Hilendarski University, Plovdiv 2010;5(37):137-42 Article in Bulgarian. 6. Penkov D, Dimitrova S, Andonova V, et al. Biological activity of Bulgarian Folia Betulae dry extract. Int J Pharm Pharm Sci 2015;7(7):289-94. 7. Zhang M, Swarts SG, Yin L, et al. Antioxidant properties of quercetin. Adv Exp Med Biol

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The Qualitative And Quantitative Determination Of The Phenolic Compounds In Polygonum Convolvulus L. Species, Polygonaceae Family


Introduction: Polygonum convolvulus L. (black bindweed), syn. Fallopia convolvulus (L.) Á. Löve, Polygonaceae family is a plant from the spontaneous flora, spread from the plain zone up to the subalpine zone. The objectives of our researches are the qualitative and quantitative determination of polyphenolic compounds from Polygoni convolvuli herba and the choice of the adequate solvent for obtaining an active pharmacological extract.

Method: The qualitative exam consisted of phytochemical screening and thin layer chromatography. The quantitative determination of the total polyphenols was made through the Folin-Ciocâlteu method.

Results: The flavonoids, the anthocyanins, the tannins and the phenol carboxylic acids (phytochemical screening) were emphasized and the following compounds were identified: rutin, hyperoside, isoquercitroside, quercetin, myricetin, kaempferol and caffeic acid.

Conclusions: In order to establish the technological lab process for obtaining an active pharmacological extract standardized in total polyphenols the adequate solvent is ethanol 50% (v/v).

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Botanical Investigation of Fallopia Dumetorum (L.) Holub (Polygonaceae) and Qualitative and Quantitative Assessment of its Polyphenolic Compounds


Background: Considering the continuous need to find new sources of polyphenolic compounds, we performed a pharmacognostical examination of the species Fallopia dumetorum (L.) Holub sin. Polygonum dumetorum L. (Polygonaceae). The plant is common in the plain regions of Romania and has not been exploited therapeutically.

Materials and method: Microscopic examination was performed on cross-sections, surface preparations and on powder obtained from the aerial parts of the flowering plant. Qualitative chemical analysis was realized by phytochemical screening and thin layer chromatography (TLC). Phenolic compounds were assayed by spectrophotometric methods: flavonoids expressed as rutin (with aluminium chloride), phenolcarboxylic acids expressed as chlorogenic acid (Arnow’s method) and proanthocyanidins expressed as cyanidin chloride (in acidic medium, by conversion to anthocyanins).

Results: The species has the following microscopic characters: anomocytic stomata, druses of calcium oxalate, sessile, pluricellular glandular hairs and pollen grains with smooth exine. Polysaccharides, reducing compounds, coumarins, sterols/triterpenes, phenol-carboxylic acids, flavones, proanthocyanidins, tannins and carotenoids were identified by phytochemical screening; chlorogenic acid, caffeic acid, quercetin and stigmasterol/beta-sitosterol were detected by TLC. F. dumetori herba has a content of 1.49 ± 0.105 g% polyphenol-carboxylic acids, 0.40 ± 0.087g% flavonoids and 0.18 ± 0.002 g% proanthocyanidins.

Conclusions: We have characterized pharmacognostically the native species F. dumentorum. Due to its content in phenolic compounds it might serve as a source of polyphenols.

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Antioxidant and Antiradical Properties of Esculin, and its Effect in A Model of Epirubicin-Induced Bone Marrow Toxicity

al. Phenolics as potential antioxidant therapeutic agents: mechanism and actions. J Mutation Research 2005;579(1-2):200-13. 8. Musialik M, Kuzmicz R, Pawłowski TS, et al. Acidity of hydroxyl groups: an overlooked infl uence on antiradical properties of fl avonoids, J Org Chem 2012;74,7:2699-709. 9. Chow H, et al. Quercetin, but not rutin and quercitrin, prevention of H2O2-induced apoptosis via anti-oxidant activity and heme oxygenase 1 gene expression in macrophages. Biochem Pharmacol 2005;69(12):1839-51. 10. Sanchez

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Memory Effects Of Aronia Melanocarpa Fruit Juice In A Passive Avoidance Test In Rats

Agric Food Chem 1992;40:1591-8. 12. Gozzani IL, Izquierdo I. Possible peripheral adrenergic and central dopaminergic infl uences in memory consolidation. Psychopharmacology 1976;49:109-11. 13. Tota S, Awasthi H, Kamat PK, et al. Protective effect of quercetin against intracerebral streptozotocin induced reduction in cerebral blood fl ow and impairment of memory in mice. Behav Brain Res 2010;209(1):73-9. 14. Valcheva-Kuzmanova S, Blagović B, Valić S. Electron spin resonance measurement of radical scavenging activity of

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Protective effect of aronia melanocarpa fruit juice in a model of cisplatin-induced cytotoxicity in vitro

1983;65(1-2):55-63. 7. Konstantinov SM, Eibl H, Berger MR. BCR-ABL infl uences the antileukaemic effi cacy of alkylphosphocholines. Br J Haematol 1999;107(2):365-80. 8. Sanchez-Gonzalez PD, Lopez-Hernandez FJ, Perez- Barriocanal F, et al. Quercetin reduces cisplatin nephrotoxicity in rats without compromising its anti-tumour activity. Nephrol Dial Transplant 2011;26(11):3484-95. 9. Kokotkiewicz A, Jaremicz Z, Luczkiewicz M. Aronia plants: a review of traditional use, biological activities, and

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