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In addition to these sources of quantifiable information, there are many other data that are more qualitative, such as the different metrics of response or tumor progression (see e.g. [ 59 ] for brain tumors), symptoms, side effects, patient performance status, etc.
All of these data are invaluable for the development, testing and application of mathematical
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to the tumor. Other pro-angiogenic factors are PDGF, PIGF or FGF. Therefore, anti-angiogenic therapies are important in the treatment of certain cancers. But, by itself, the antiangiogenic treatment only prevents the tumor from developing its support of blood vessels and does not directly destroy the cancer cells. In fact, the benefits of using anti-angiogenic therapies alone are, at best, transient and are followed by the restoration of tumor growth and progression [ 4 ]. As a consequence, it is common not to limit the treatment to a body, but to combine different