Sylwia Tobólska, Sylwia Terpiłowska, Jerzy Jaroszewski and Andrzej Krzysztof Siwicki
use of mammalian cells in in vitro tests increases the sensitivity for the detection of rodent carcinogens and extends the spectrum of genetic incidences detected. A battery approach is reasonable because no single test is able to detect all genotoxic mechanisms. The general features of a standard test battery are as follows:
1. assessment of mutagenicity in a bacterial reverse gene mutation test by Ames;
2. genotoxicity evaluated in mammalian cells in vitro and/or in vivo by comet and micronuclei assays ( 10 ).
The aim of the presented work was to