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M. Ferdows, Md. Shakhaoath Khan, Md. Mahmud Alam and A. A. Afify

Abstract

The study of radiative heat transfer in a nanofluid with the influence of magnetic field over a stretching surface is investigated numerically. Physical mechanisms responsible for magnetic parameter, radiation parameter between the nanoparticles and the base fluid, such as Brownian motion and thermophoresis, are accounted for in the model. The parameters for Prandtl number Pr, Eckert number Ec, Lewis number Le, stretching parameter b/a and constant parameter m are examined. The governing partial differential equations were converted into nonlinear ordinary differential equations by using a suitable similarity transformation, which are solved numerically using the Nactsheim-Swigert shooting technique together with Runge-Kutta six order iteration scheme. The accuracy of the numerical method is tested by performing various comparisons with previously published work and the results are found to be in excellent agreement. Numerical results for velocity, temperature and concentration distributions as well as skin-friction coefficient, Nusselt number and Sherwood number are discussed at the sheet for various values of physical parameters.

Open access

Florent Bernard, Viktor Fischer and Boyan Valtchanov

References [1] BUCCI, M.-LUZZI, R.: Design of testable random bit generators , in: Cryptographic Hardware and Embedded Systems-CHES ’05, 7th International Workshop (J. Rao, B. Sunar, eds.), Lecture Notes in Comput. Sci., Vol. 3659, Springer-Verlag, Berlin, 2005, pp. 147-156. [2] KOHLBRENNER, P.-GAJ, K.: An embedded true random number generator forFPGAs , in: Proc. of the 2004 ACM/SIGDA 12th Internat. Symposium on Field Programmable Gate Arrays-FPGA 04, ACM New York, NY, 2004, pp. 71-78. [3] SUNAR, B

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Marilena Crupi and Giancarlo Rinaldo

, Four strikes against physical mapping of DNA , J. Comput. Biol., 2 (1995), 139–152. [10] M. C. Golumbic, Algorithm Graph Theory and Perfect graphs , Academic Press, New York, N.Y., 1980. [11] M. Habib, R. McConnel, C. Paul, L.Viennot, Lex-BFS and partition refinement, with applications to transitive orientation, interval graph recognition, and consecutive one testing , Theoret. Comput. Sci., 234 (2000), 59–84 [12] G. Hajós, Über eine Art von Graphen , Internat. Math. Nachrichten, 11 (1957) problem 65. [13] P. Heggernes, D. Meister, C

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Aleksander Weron

References [1] Barkai E., Metzler R., Klafter J., From continuous time random walks to the fractional Fokker-Planck equation, Phys. Rev. E 61 (2000), 132-138. [2] Barndorff-Nielsen O.E., Normal//inverse Gaussian Processes and the Modelling of Stock Returns, Research Report 300, Department of Theoretical Statistics, University of Aarhus, 1995. [3] Beran J., Statistics for Long-Memory Processes, Chapman and Hall, New York, 1994. [4] Brcich R.F., Iskander D.R., Zoubir A.M., The stability test for

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Ilze Radoviča, Rūdolfs Bērziņs, Gustavs Latkovskis, Dāvids Fridmanis, Liene Ņikitina-Zaķe, Kārlis Ventiņš, Guna Ozola, Andrejs Ērglis and Jānis Kloviņš

Abstract

Familial hypercholesterolemia (FH) is one of the most common single gene disorders, which is mostly inherited as an autosomal dominant trait. The physical signs of FH are elevated low density lipoprotein cholesterol (LDL-C), elevated total cholesterol (TC) levels and tendon xantomas. Identification and early treatment of affected individuals is desirable and in lack of physical symptoms DNA-based diagnosis provides confirmation of diagnosis and enables early patient management. The majority of FH cases are caused by mutations in four genes (APOB, LADLR, PCSK9, and LDLRAP1). There are commercial kits available for testing of the 20 most common FH causing mutations, but the spectrum of disease-causing mutations is quite diverse in various populations and these tests cover only a minority of disease-causing genetic variants. There is therefore a need to determine the full spectrum of mutations in LDLR, APOB, PCSK9, and LDLRAP1 genes in each population. Here we report mutations found in 16 patients with suspected FH in a sample from the Genome Database of the Latvian population enrolled at the Latvian Centre of Cardiology. We used the next generation sequencing approach to determine the full spectrum of mutations in coding regions of LDLR, APOB, PCSK9, and LDLRAP1. In total we found 22 missense mutations, from which only rs5742904 (Arg3527Gln) in APOB gene had been previously described as a FH-causing mutation confirming FH in one patient. Possible FH-causing mutations however, were identified in the majority of patients. The conclusion is that the most commonly employed commercial mutation panel is not sufficient for diagnosis of FH patients and NGS can help to identify FH-causing mutations in the Latvian population.

Open access

Māra Bleidere, Sanita Zute and Ida Jākobsone

Abstract

Incorporation of whole grain, such as hulless barley, as a part of a balanced diet can help reduce the risk of coronary heart diseases, diabetes and specific cancers, and provide other health benefits as well. The objectives of this study were to determine the physical and chemical characteristics of grains of hulless barley genotypes from the Latvian spring barley programme. Field experiments were carried out in 2010-2011 at the State Stende Cereal Breeding Institute. Grain samples of 29 hulless spring barley breeding lines were analysed for grain physical traits (1000 kernel weight, test weight), macronutrients (crude protein, starch, β -glucans), and micronutrients (total phenolic content, DPPH antiradical scavenging activity and α-tocopherol content). The variation of physical traits and macronutrients was mainly determined by genotype (ω2 = 32-62%) and year (η2 = 8-42%) and to a lesser extent by interaction of factors. The difference between hulless genotypes, as indicated the coefficient of variation, was rather high for all micronutrients (V% = 13.4-25.6). Significant (P < 0.05) positive correlation was detected between radical scavenging activity and total phenolic content (r = 0.519) and starch content (r = 0.530). The best hulless breeding lines ‘1185’ and ‘IC 360’ (variety ‘Kornelija’ submitted for DUS and VCU tests) were selected for future usage in clinical investigations.

Open access

Elīna Pūcīte, Marius Šlisers, Evija Miglāne, Dainis Krieviņš, Andrejs Millers and Inese Blimhena

Abstract

Information about changes of health-related quality of life (HRQoL) after revascularisation as well how revascularisation procedure influences daily activities, cognitive functioning and general health is controversial. The objectives of our study were to evaluate and describe the HRQoL among patients with severe carotid artery disease; to evaluate the difference of HRQoL between symptomatic and asymptomatic carotid artery disease; and to explore the possible associations between some demographic and clinical characteristics of patients with carotid artery disease and HRQoL. The cross-sectional study included 33 patients who were referred for carotid artery endarterectomy. Data assessment was done one to three days before surgery. The HRQoL was assessed using the Medical Outcome Survey Form 36 (SF-36v2). Patients with symptomatic carotid artery disease had the lowest mean SF-36v2 scores for physical functioning, role-physical, general health and mental health. There was moderate correlation (rs = 0.441) between mean SF- 36v2 scores of mental health and Montreal Cognitive Assessment Scale (MoCA) scores. There is also indirect indication for probable correlation between MoCA test scores and mean SF-36v2 scores of social functioning, which might become statistically significant if more patients would be included. Patients with severe carotid artery disease in our study had lower mean SF-36v2 scores for role-physical, for bodily pain and for perception about their health status (general health). HRQoL in patients with severe carotid artery, stenosis was poorer in patients with symptomatic carotid artery disease and was not affected by gender and other clinical characteristics.

Open access

Iveta Mintāle, Inga Narbute, Sanda Jēgere, Milāna Zabunova, Dace Lūriņa, Iļja Zakke, Vilnis Dzērve and Andrejs Ērglis

, 111 , 3481-3488. Mintāle, I., Ērglis, A. (2008). Fiziskās slodzes testi. Metodiskie norādījumi [Recommendations of the Latvian Society of Cardiology on physical exercise tests]. Latvijas Kardiologu biedrība. Rīga, 48 lpp Pepine, CJ., Cohn, P.F., Deedwania, P.C., Gibson, R.S., Handberg, E., Hill, J.A., Miller, E., Marks, R.G., Thadani, U. (1994). Effects of treatment on outcome in mildly symptomatic patients with ischemia during daily life: The atenolol silent ischemia study (ASIST). Circulation , 90 , 762

Open access

Marija Avota, Anita Raciborska and Andrejs Avots

Foot problems of female medical personnel: Subjective complaints and results of the podometric test

The research was carried out in a multi-profile clinic where female medical workers included nurses, doctors and nurse assistants. The number of respondents included in the data analysis of this research was 102. A standardised questionnaire was used to obtain data on age group, position, body mass index, physical activities, ergonomic factors at work, performed objective foot examination methods, awareness of the ways of feet deformation correction. A computerised foot diagnostic system Pad Professional was used to objectively assess the feet condition. The podometric examination was carried out on 78 respondents. The data indicated a widespread foot problem spread among medical workers. Of 102 respondents only 10 (4.2%) had no complaints, and of 78 respondents who underwent the podometric test, none were diagnosed as having a totally healthy foot. The podometric examination showed that 65 (83.3%), which was the vast majority of respondents, had transverse arch flattening. Explicit transverse arch flattening was diagnosed in 8 (10.3%) and longitudinal arch flattening in 5 (6.4%) respondents.

Open access

Noël Barengo, Dana Misiņa, Lauma Zariņa, Jānis Kloviņš, Dita Ozola, Andra Dērveniece, Linda Tarāsova and Valdis Pīrāgs

Glucose Metabolism Disorders and Risk Factors of Type 2 Diabetes in 45-74-Years-old Population in Rīga, Latvia

The aims of this study were to investigate the current prevalence of abnormal glucose tolerance (AGT), compare the risk factor profile between persons with and without AGT among 45-74 years-old Latvian men and women, and to validate the Finnish diabetes risk score (FINDRISC) questionnaire in detecting AGT in the middle-aged Latvian population. A cross-sectional survey among the 45-74-years old population randomly selected from the registers of general practitioners in Rīga, Latvia was carried out between April 2008 and March 2009. The survey consisted of a questionnaire, measurements such as height, weight, waist circumference, and blood pressure as well as blood oral glucose tolerance test (OGTT), cholesterol and its fractions. Prevalence of obesity, central obesity and physical inactivity were high in the Latvian population. Women with AGT had a worse risk factor profile for T2D and cardiovascular diseases compared to those with normal glucose tolerance. No differences were found in the risk factor profile between men with and without AGT. A high proportion of men and women with more than 11 FINDRISC points had undetected AGT. The FINDRISC questionnaire can be used in clinical practice to detect persons with AGT in the Latvian population.