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D. Fleskova, G. Nosalova, Sudipta Saha, Shruti Bandyopadhyay, Ray Bimalendu and L. Jurecek

Antitussive Effect of a Pectic Arabinogalactans Isolated from Adhatoda Vasica in Vivo Experimental Conditions

The herbal polysaccharides have been the subject of many studies for a very long time, especially because of their physical properties, chemical and physical modification and application. Adhatoda vasica has also been traditionally included in preparations for the relief of cough, asthma and bronchitis recommended by Ayurvedic physicians for the management of various types of respiratory disorders. In this study, we have focused on activities of pectic arabinogalactans isolated from Adhatoda vasica on experimentally induced cough reflex and the changes of specific airway resistance in vivo conditions. The substance from leaves of Adhatoda vasica was marked as P-601 and the substance from stem bark of this shrub as P-602. The aim of presented study was to compare the antitussive activity of isolated arabinogalactans with cough suppressive activity of codeine ("positive" control) and effect acquired after application of water for injection ("negative" control). Conscious male Trik guinea pigs (200-350g) were exposed to citric acid aerosol. Peroral administration of these substances in a dose of 50 mg.kg-1 body weight decreased the number of citric acid induced cough efforts in guinea pigs more effectively than codeine. They did not induce any significant changes in the values of specific airway resistance and did not provoke any observable adverse effects. Our test results confirmed that polysaccharides isolated from Adhatoda vasica in vivo conditions have expressive antitussive effect compared with the oldest and the most effective cough suppressive agent - the codeine. The positive thing is the studied substances, despite strong supressive activity, did not induced any adverse side effects.

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A Sujanska, P Durdik and P Banovcin

. 2012; 3: 909-911. 27. Huang Y, Chen N, Guilleminault Ch. Neurocognitive testing in children with and without OSA. Sleep Medicine. 2006; 7: 1-27. 28. Nixon GM, Wawruszak M, Verginis N, Davey MJ. The pediatric daytime sleepiness in elementary school children. Sleep Medicine. 2006; 7: 1-127.

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T Vasicko, J Prindesova-Busikova and O Osina

, Kim Y, Kim J, Hwang Y, Cho B, Hong T, Sung B, Lee Y. Effects of high occupational physical activity, aging, and exercise on heart rate variability among male workers. Ann Occup Environ Med. 2015; 27: 22. 10. Hu GC, Chien KL, Hsieh SF, Chen CY, Tsai WH, Su TC. Occupational versus leisure-time physical activity in reducting cardiovascular risks and mortality among ethnic Chinese adults in Taiwan. Asia Pac J Public Health. 2014; 26(6): 604-13. 11. Hautala AJ, Kiviniemi AM, Tulppo MP. Individual responses to aerobic exercise: The role of the autonomic

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A Hamrakova, I Ondrejka, N Sekaninova, L Peregrim and I Tonhajzerova

): e0197739. 19. Hall WD. An Overview of the Autonomic Nervous System editors. Clinical Methods: The History, Physical, and Laboratory Examinations. 3rd ed. Boston: Butterworths; 1990. Chapter 75. 20. McCorry LK. Physiology of the Autonomic Nervous System. Am J Pharm Educ 2007; 71 (4): 78. 21. Cortese S. The neurobiology and genetics of Attention-Deficit/Hyperactivity Disorder (ADHD): What every clinician should know. Eur J Paediatr Neurol 2012; 16 (5): 422-433. 22. Rukmani MR, Seshadri SP, Thennarasu K, Raju TR, Sathyaprabha TN. Heart Rate

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Szaboova V., Svlhrova V. and Hudeckova V.

cervical cancer screening in Mulanje, Malawi: a qualitative study. Patient Prefer Adherence 2011; 5: 125-31. 17. Bakogianni GD, Goutsou SC, Liti MV et al. Knowledge, attitude, and practice of cervical cancer screening among Greek students: a short report. Int J Adolesc Med Health 2012; 24 (4): 329-30. 18. Yanikkerem E, Goker A, Piro N et al. Knowledge about cervical cancer, Pap test and barriers towards cervical screening of women in Turkey. J Cancer Educ 2013; 28 (2): 375-83. 19. Black AT, McCulloch A, Martin RE et al

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C. Popescu, Violeta Bojincă, Daniela Opriş and Ruxandra Ionescu

alternative perspective . Am J ClinNutr 1996; 63 : 448S-451S. 27. ARMSTRONG T, BULL F. Development of the World Health Organization Global Physical Activity Questionnaire (GPAQ) . Journal of Public Health 2006; 14 : 66-70. 28. BULL FC, MASLIN TS, ARMSTRONG T. Global physical activity questionnaire (GPAQ): nine country reliability and validity study. J Phys Act Health 2009; 6: 790-804. 29. WESTHOVENS R, NIJS J, TAELMAN V, DEQUEKER J. Body composition in rheumatoid arthritis. Br J Rheumatol 1997; 36 : 444-448. 30. AKAR S, SARI I, COMLEKCI A

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Mariana Mihăilă, V. Herlea, Camelia Dobrea, Ioana Lupescu, Gina Rusu Munteanu, Grethi Chiriac, L. Micu, R. Serescu and I. Copaci

Abstract

We present the case of a 76 year old female patient admitted in the Department of Cardiology for physical asthenia, profuse sweating and dyspnea with orthopnea for about one month. Clinical and paraclinical assessments performed at admission confirmed the diagnosis of cardiac tamponade. Surgical intervention was performed and 400 mL of clear effusion were drained. Post-operative evolution was marked by recurrence of symptoms, requiring after 3 weeks a new drainage of 600 mL of clear effusion, and biopsy of the pericardium was performed. Pathological exam described serous pericarditis with chronic inflammatory infiltrate, xanthogranulomatous reaction intricated in the pericardium and mesothelial hyperplasia. The patient was subsequently transferred to the Department of Internal Medicine for further investigations. Physical examination showed a patient with altered general status, pallor, vesicular murmur absent in both bases, presenting cutaneous hyperpigmentation at the level of the right hemi-abdomen and hip with posterior extension, and a peripheral indurated erythematous plaque. The patient presented nodular masses of 3 cm in the right latero-cervical and bilateral axillary regions, non-adherent to the superficial structures, as well as adenopathic blocks in both inguinal regions. CT scan of the thorax and abdomen showed moderate bilateral pleuresia, minimal pericardial effusion (15 mm) and multiple adenopathies on both sides of the diaphragm. Skin biopsy was performed, as well as bone marrow aspirate and excision of a right axillary lymph node. Pathological exams and immunohistochemistry tests confirmed the diagnosis of Plasma Cells Castleman disease.

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Monica Jurcău, Mariana Floria, Bogdan Mazilu, Anca Ouatu and Daniela Maria Tanase

Abstract

Introduction: We present the case of a young man with multiple atherosclerotic risk factors and a rare cause of angina and supraventricular ectopic beats.

Case presentation: A 35-year-old man with one-year history of stable angina pectoris and supraventricular ectopic beats, without any medication, presented to the emergency room complaining of anterior chest pain that occurs at moderate physical exertion. The rest electrocardiogram, transthoracic echocardiography, and chest X-ray were normal; the exertion stress test was also normal, except for supraventricular ectopic beats (trigeminal rhythm). Due to the intermediate pre-test probability of coronary artery disease, he was evaluated using coronary computed tomography angiography. An anomalous origin of the right coronary artery from the left coronary sinus, with an inter-arterial course and without any atheroma plaques, was observed. During hospitalization the evolution was stable, without complications. The patient was further referred to a cardiac surgery clinic to evaluate the possibility of surgical treatment of this anomaly.

Conclusions: Coronary artery anomalies are very rare; however, they present multiple implications in current practice. The most severe complication of this condition is represented by sudden death in young patients due to malignant ventricular arrhythmias. Imaging diagnostic techniques allow for a rapid, noninvasive diagnosis of this rare cause of angina.

Open access

Bennur Esen, Emel Sağlam Gokmen, Mahmut Kaya, Burak Ozkan and Ahmet Engin Atay

under special dietary restrictions. The participants underwent physical examination, and demographic features of the participants were recorded. All the subjects read and signed the informed consent forms before enrolling into the study. The ethics committee of the Bagcilar Education and Research Hospital approved the study. Methods Blood samples were collected after a 12-h fasting period. Biochemical variables including serum glucose, urea, creatinine, uric acid, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH

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Seyed Reza Hosseini, Naghi Baghitabar, Ali Mirzapour, Farshid Oliaei, Hajighorban Nooreddini, Ali Bijani and Simin Mouodi

with fracture occurrence . Clin J Am Soc Nephrol. 2010; 5 (2):275-80. 13. AFSHINNIA F., SUNDARAM B., ACKERMANN RJ., WONG KK. Hyponatremia and osteoporosis: reappraisal of a novel association . Osteoporos Int. 2015; 26 (9):2291-8. 14. HOSSEINI SR., CUMMING RG., KHEIRKHAH F., NOOREDDINI H., BAIANI M., MIKANIKI E., et al . Cohort profile: the Amirkola Health and Ageing Project (AHAP) . International Journal of Epidemiology. 2014; 43:1393–1400. 15. PICKENBROCK HM., DIEL A., ZAPF A. A comparison between the Static Balance Test and the Berg Balance