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Allison Grieg

References 1 Richards M, Williams M, Chalmers E et al. A United Kingdom Haemophilia Centre Doctors’ Organization guideline approved by the British Committee for Standards in Haematology: guideline on the use of prophylactic factor VIII concentrate in children and adults with severe haemophilia A. Br J Haematology 2010; 149: 498;507. 2 Morfini M. Pharmacokinetics of factor VIII and factor IX. Haemophilia 2003; 9 <Suppl 1=: 94;9.. 3 Bjorkman S. Prophylactic dosing of factor VIII and factor IX from a clinical

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David Perry

VIII Fc fusion protein in severe hemophilia A. Blood 2014; 123(3): 317-25. doi: 10.1182/blood-2013-10-529974. 9. Collins PW, Fischer K, Morfini M, et al. Implications of coagulation factor VIII and IX pharmacokinetics in the prophylactic treatment of haemophilia. Haemophilia 2011; 17: 2-10. 10. Chowdary P, Lethagen S, Friedrich U, et al. Safety and pharmacokinetics of anti-TFPI antibody (concizumab) in healthy volunteers and patients with hemophilia: a randomized first human dose trial. J Thromb Haemost 2015; 13(5): 743-54. doi: 10

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Bert Leenders

: 3858B3864. 4. Lindley CM, Sawyer WT, Macik BG, et al. Pharmacokinetics and pharmacodynamics of recombinant factor VIIa. Clin Pharmacol Ther 1997; 55: 638B648. 5. Yatuv R, Dayan I, CarmelBGoren L, et al. Enhancement of factor VIIa haemostatic efficacy by formulation with PEGylated liposomes. Haemophilia 2008; 14: 476B483 6. Weimer T, Wormsbächer W, Kronthaler U, et al. Prolonged inBvivo half life of factor VIIa by fusion to albumin. Thromb Haemost 2008; 99: 659B667 7. Leissinger C, Gringeri A, Antmen B

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Steve Chaplin

References 1. Nilsson IM. Clinical pharmacology of aminocaproic and tranexamic acids. J Clin Pathol Suppl (R Coll Pathol) 1980;14:41-7. 2. Wikipedia. Tranexamic acid. Available from: (accessed 18 March 2016). 3. Grassin-Delyle S, Tremey B, Abe E, et al. Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass. Br J Anaesth 2013;111:916-24. 4. Pfizer Ltd. Cyclokapron injection. 5.1 Pharmacodynamic

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Galila Mokhtar, Amal El-Beshlawy, Mohssen El Alfy, Magdy El Ekiaby, Naglaa Omar, Khaled Abd El-Azim Eid, Hoda Hassab, Osama El Safy, Ahmed Mansour, Rasha El Ashry, Naglaa Shaheen and Azza Abdel Gawad

-8. 25. Fischer K, van der Bom JG, Molho P, et al. Prophylactic versus on-demand treatment strategies for severe haemophilia: a comparison of costs and long-term outcome. Haemophilia 2002; 8: 745-52. 26. Elekiaby A, El Saied H, Elekiaby M. Five years of tailored low dose prophylaxis in a small cohort of kids with severe hemophilia A using SD-F cryoprecipitate. Poster no. PO169 presented at the World Federation of Hemophilia Congress; 24-28 July 2016; Orlando, FL. 27. El-Kiaby M, Goubran HA, Radosevich M, et al. Pharmacokinetic study of