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Bioequivalence of indinavir capsules in healthy volunteers

. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother. 1998; 42:332-8. 5. Hsu A, Granneman GR, Cao G, Carothers L, Japour A, El-Shourbagy T, et al. Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers. Antimicrob Agents Chemother. 1998; 42:2784-91. 6. The United States Pharmacopoeial Convention, Inc. The United States Pharmacopeia 26 / National Formulary 21. Rockville, USA; 2003. 7. Drug Control Division. Thailand Guidelines for the Conduct of

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Bioequivalence study of cefepime intramuscular injection

References 1. Mutnick AH, Rhomberg PR, Sader HS, Jones RN. Antimicrobial usage and resistance trend relationships from the MYSTIC Programme in North America (1999-2001). J Antimicrob Chemother. 2004; 53:290-6. 2. Barradell LB, Bryson HM. Cefepime: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1994; 47:471-505. 3. Yahav D, Paul M, Fraser A, Sarid N, Leibovici L. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet Infect Dis. 2007; 7

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How specialist nurse-led care can help to lower the costs of prophylaxis

References 1 Richards M, Williams M, Chalmers E et al. A United Kingdom Haemophilia Centre Doctors’ Organization guideline approved by the British Committee for Standards in Haematology: guideline on the use of prophylactic factor VIII concentrate in children and adults with severe haemophilia A. Br J Haematology 2010; 149: 498;507. 2 Morfini M. Pharmacokinetics of factor VIII and factor IX. Haemophilia 2003; 9 <Suppl 1=: 94;9.. 3 Bjorkman S. Prophylactic dosing of factor VIII and factor IX from a clinical

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Effect of MIC interpretative breakpoint revision on cephalosporin and carbapenem susceptibility among ESBL-producing Enterobacteriaceae

methods: report from the SENTRY Antimicrobial Surveillance Program. Diagn Microbiol Infect Dis. 2006; 54:231-6. 11. Paterson DL. Resistance in Gram-negative bacteria: Enterobacteriaceae. Am J Med. 2006; 119 Suppl 1:S20-S8. 12. Frei CR, Wiederhold NP, Burgess DS. Antimicrobial breakpoints for gram-negative aerobic bacteria based on pharmacokinetic-pharmacodynamic models with Monte Carlo simulation. J Antimicrob Chemother. 2008; 61:621-8. 13. Kahlmeter G. Breakpoints for intravenously used cephalosporins in

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Association of CYP3A5 and POR polymorphisms with the maintenance tacrolimus dosage requirement in Thai recipients of kidney transplants

interindividual variability is found in tacrolimus pharmacokinetics, particularly in the dosage required to achieve target blood concentrations [ 2 ]. The recommended C 0 levels of tacrolimus are 10 to 20 ng/mL during the first 3 months after transplantation (induction phase), followed by C 0 levels of 5 to10 ng/mL during the maintenance phase. Significant toxicity is seen with C 0 levels of 15 ng/mL [ 3 ]. Subsequent trials often used for C 0 ranged between 7 to 8 ng/mL in the early post-transplantation period, and 5 to 7 ng/mL during the maintenance phase. An

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Fexofenadine and levocetirizine have equivalent effectiveness for persistent allergic rhinitis

antihistamines, while astemizole and terfenadine have been removed from the market in most countries because of their potential to the prolong QT interval, and cause serious polymorphic ventricular arrhythmias, such as torsades de pointes [ 3 ]. Various types of H 1 -receptor antagonists have various pharmacokinetic and pharmacodynamics properties. To date, fexofenadine, levocetirizine. and desloratadine are considered third generation antihistamines. Each drug has an advantage over the others. Among these three, desloratadine has the highest affinity for binding receptors

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The use of Monte Carlo simulation to predict vancomycin dosage for methicillin-resistant Staphylococcus aureus in Thai patients of various ages and with varying degrees of renal function

pharmacokinetics in Thai patients [ 6 ]. The study illustrated that creatinine clearance (CL cr ) calculated by the Cockcroft–Gault equation and age were covariates of vancomycin clearance (CL v ) and volume of the central compartment ( V c ), respectively. Thus, suitable vancomycin dosage could vary depending on CL cr and age. In addition, MRSA susceptibility data to vancomycin is a crucial factor for evaluating proper vancomycin dosing. Canut et al. determined suitable vancomycin dosages for European patients with MRSA infection [ 7 ]. The study revealed that Belgian patients

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Comparative study of effective-site target controlled infusion with standard bolus induction of propofol for laryngeal mask airway insertion

. A general method for calculating the dosage scheme in linear pharmacokinetics. Eur J Clin Pharmacol. 1981; 20:379-86. 9. Shafer SL, Gregg KM. Algorhithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pump. J Pharmacokinet Biopharm. 1992; 20:147-69. 10. Schnider T, Minto C, Shafer SL, Gambus PL, Andresen C, Goodale DB, Youngs EJ. The influence of age on propofol pharmacodynamics. Anesthesiology.1999; 90:1502-16. 11. Struys MMRF, De Smet T

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Into the future with novel emerging therapies for haemophilia

VIII Fc fusion protein in severe hemophilia A. Blood 2014; 123(3): 317-25. doi: 10.1182/blood-2013-10-529974. 9. Collins PW, Fischer K, Morfini M, et al. Implications of coagulation factor VIII and IX pharmacokinetics in the prophylactic treatment of haemophilia. Haemophilia 2011; 17: 2-10. 10. Chowdary P, Lethagen S, Friedrich U, et al. Safety and pharmacokinetics of anti-TFPI antibody (concizumab) in healthy volunteers and patients with hemophilia: a randomized first human dose trial. J Thromb Haemost 2015; 13(5): 743-54. doi: 10

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Review article. Assessing clinical evidence of drug interactions between citrus juices and cyclosporine

caused by coadministration of decoctions of the fruits of Citrus aurantium and the pericarps of Citrus grandis. Planta Med. 2000; 66:653-5. 20. Grenier J, Fradette C, Morelli G, Merritt GJ, Vranderick M, Ducharme MP. Pomelo juice, but not cranberry juice, affects the pharmacokinetics of cyclosporine in humans. Clin Pharmacol Ther. 2006; 79:255-62. 21. Castillo JREd, Elsener J, Martineau GP. Pharmacokinetic modeling of in-feed tetracyclines in pigs using a meta-analytic compartmental approach. Swine Health Prod. 1998; 6

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