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A. Jasiecka, T. Grabowski, T. Maślanka, H. Ziółkowski and J.J. Jaroszewski

129: 1010-1019. FDA and CDER. Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research: Rockville, MD ( 2001 ). Jang SB, Lee YJ, Lim LA, Park KM, Kwon BJ, Woo JS, Kim YI, Park MS, Kim KH, Park K ( 2010 ) Pharmacokinetic comparison of controlled-release and immediate-release oral formulations of simvastatin in healthy Korean subjects: a randomized, open-label, parallel-group, singleand multiple-dose study. Clin Ther 32: 206

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Sofiya Ivanova, Dimitrichka Dimitrova and Metodi Petrichev

). Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs. Veterinary Quarterly 10, 156-163. https://doi.org/10.1080/01652176.1988.9694165 PMid:3176294 7. Walker, R.D., Stein, G.E., Hauptman, J.G., MacDonald, K.H., Budsberg, S.C., Rosser, E.J.Jr. (1990). Serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs. American Journal of Veterinary Research 51, 896-900. 8. Parikh, V., Shivprakash, K., Patel, D., Gandhi, T

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Natalia Francisca Urzúa Pizarro, Carlos Alberto Errecalde, Guillermo Fermin Prieto, Carlos Fernando Lüders, María Paula Tonini and Eduardo Jesús Picco

., Wang, L., Shen, X., Gu, X., Zeng, D., Zeng, Z. (2013). Plasma and tissue pharmacokinetics of marbofloxacin in experimentally infected chickens with Mycoplasma gallisepticum and Escherichia coli. J. Vet. Pharmacol. Ther. 36, 511-515. https://doi.org/10.1111/jvp.12049 PMid:23550715 5. El-Komy, A., Attia, T., El Latif, A., Fathy, H. (2016). Bioavailability pharmacokinetics and residues of marbofloxacin in normal and E. coli infected broiler chicken. In. J. Pharmacol. Tox. 2 (4): 144-149. 6. Huang, X., Chen, Z., Zhang, S., Zeng, Z. (2003). Influence of

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Neno Bratoev, Aneliya Milanova, Ivelina Pavlova and Lubomir Lashev

REFERENCES 1. Pijpers, A., Van Klingeren, B., Schoevers, E.J., Verheijden, J.H.M., Van Miert, A.S. (1989). In vitro activity of five tetracyclines and some other antimicrobial agents four porcine respiratory tract pathogens. J. Vet. Pharmacol. Ther. 12, 267–276. http://dx.doi.org/10.1111/j.1365-2885.1989.tb00670.x PMid:2810475 2. Anadón, A., Martínez-Larra-aga, M.R., Diaz, M.J., Bringas, P., Fernandez, M.C., Fernandez-Cruz, M.L., Iturbe, J., Martínez, M.A. (1994). Pharmacokinetics of doxycycline in broiler chickens. Avian Pathol. 23, 79-90. http

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R. Sokół, M. Raś-Noryńska, M. Michalczyk, A. Jasiecka, H. Ziółkowski and J. Jaroszewski

-21. Demeulenaere D, Vercruysse J, Dorny P, Claerebout E ( 1997 ) Comparative studies of ivermectin and moxidectin in the control of naturally acquired cyathostome infections in horses. Vet Rec 141: 383-386. Drudge JH, Lyons ET ( 1989 ) Internal parasites of equids with emphasis on treatment and control. (Revision) Monopgraph, Hoechest-Roussel Agri-Vet, Somerville, NJ, p 26. Dupuy J, Yin H, Luo JX, Yang DY, Guan GQ, Ma ML, Sutra JF, Lespine A, Boulard C, Alvinerie M ( 2003 ) Pharmacokinetics of ivermectin in the yak ( Bos grunniens ). Vet Parasitol 117: 153

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Dimitrichka Dimitrova, Anna Arnaudova-Matey, Petar Dilov, Geno Angelov, Tandju Mehmedov, Toni Todorov, Denka Kushvalieva, Dimitrina Nikolova and Valija Dilova

References 1. Geisser, P., Burckhardt, S. (2011). The Pharmacokinetics and Pharmacodynamics of Iron preparations. Pharmaceutics, 3(1): 12-33. 2. Egli, A. K., Franstad, T., Gramingen, D. (1998). The effect of per oral administration of aminoacid chelated iron to pregnant sows in prevention sow and piglet anemia. Acta Veterinaria Scandinavica 39(1): 77-87. 3. Andrews, N. C. (1999). Disorders of iron metabolism. The New England Journal of Medicine 341, 1986-1995. 4. Kalantaz-Zadeh, K. E., Steja, E

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Małgorzata Gbylik-Sikorska, Anna Gajda, Artur Burmańczuk, Tomasz Grabowski and Andrzej Posyniak

References 1. de Boer V.C., Dihal A.A., van der Woude H., Arts I.C., Wolffram S., Alink G.M., Rietjens I.M., Keijer J., Hollman P.C.: Tissue distribution of quercetin in rats and pigs. J Nutrit 2005, 135, 1718–1725. 2. Chang L., Ren Y., Cao L., Sun Y., Sun Q., Sheng N., Yuan L., Zhi X., Zhang L.: Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC–MS/MS. J Chrom B 2012, 904, 59–64. 3. Coppin J.P., Xua Y., Chena H., Pan M.H., Hoc Ch.T., Juliani R., Simon J.E., Wu Q

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L. Carlucci, K.H. Song, H.I. Yun, H.J. Park, K.W. Seo and M. Giorgi

) Pharmacokinetic/pharmacodynamic modeling in drug research and development. J Clin Pharmacol 40: 1399-1418. Fassler PE, Tranquilli WJ, Paul AJ, Soll MD, DiPietro JA, Todd KS (1991) Evaluation of the safety of ivermectin administered in a beef-based formulation to ivermectin- sensitive Collies. J Am Vet Med Assoc 199: 457-460. Gabrielsson J, Weiner D (2002) Pharmacokinetic and Pharmacodynamic Data Analysis: Concepts and Applications, Swedish Pharmaceutical Press, Stockholm, Sweden. German AJ (2006) The growing problem of obesity in

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A. Burmańczuk, T. Grabowski, T. Błądek, C. Kowalski and P. Dębiak

Drugs. Cephalosporin Drugs. Extralabel Animal Drug Use. Order of Prohibition 735-744. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295364/ Gibaldi M, Perrier D ( 1982 ) Pharmacokinetics. 2nd ed. Marcel Dekker, New York. Grabowski T, Marczak M, Jaroszewski JJ, Whitmire M ( 2012 ) Comparison of bioequivalence study regulatory requirements for human and veterinary drugs. Regul Toxicol Pharmacol 64: 233-242. Gruet P, Maincent P, Berthelot X, Kaltsatos V ( 2001 ) Bovine mastitis and intramammary drug delivery: review and perspectives. Adv Drug Deliv Rev

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H. Ziółkowski, J.J. Jaroszewski, N. Ziółkowska and A. Jasiecka

References Adusumalli VE, Gilchrist JR, Wichmann JK, Kucharczyk N, Sofia RD ( 1992 ) Pharmacokinetics of felbamate in pediatric and adult beagle dogs. Epilepsia 33: 955-960. Adusumalli VE, Yang JT, Wong KK, Kucharczyk N, Sofia RD ( 1991 ) Felbamate pharmacokinetics in the rat, rabbit, and dog. Drug Metab Dispos 19: 1116-1125. Ambrósio AF, Silva AP, Malva JO, Soares-da-Silva P, Carvalho AP, Carvalho CM ( 2001 ) Inhibition of glutamate release by BIA 2-093 and BIA 2-024, two novel derivatives of