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Liquid chromatographic enantioseparation of thalidomide and its derivatives on cyclodextrin-bonded stationary phases

Irodalomjegyzék 1. Eriksson T, Bjorkman S, Hoglund P. Clinical pharmacology of thalidomide. Eur J Clin Pharmacol. 2001; 57(5):365-376. 2. Melchert M, List A. The thalidomide saga. Int J Biochem Cell Biol. 2007; 39(7-8):1489-1499. 3. Ridings JE. The thalidomide disaster, lessons from the past. Methods Mol Biol. 2013; 947:575-586. 4. Eriksson T, Bjorkman S, Roth B, Hoglund P. Intravenous formulations of the enantiomers of thalidomide: pharmacokinetic and initial pharmacodynamic characterization in man. J Pharm Pharmacol. 2000; 52

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Morphological and pharmacokinetic properties of oral solid dietary supplements containing plant extracts

Summary

Introduction: Dietary supplements are a good way to supplement the deficiency of certain micronutrients and organic components (therapeutic agents) in human body. They are most often available in concentrated form as tablets, capsules, powder or liquid.

Objective: To investigate morphological parameters and the pharmaceutical availability of coated tablets – dietary supplements – that contain selected pharmacopeial titrated dry plant extracts.

Methods: Testing of the effective time of the tablet surface erosion was performed in model acceptor fluids using pharmacopeial methods in static (Erweka apparatus) and dynamic (unlimited diffusion method) conditions. Furthermore, morphological parameters of tablets (the original shape of an ellipse) as well as their hardness were determined.

Results: The effective erosion time was determined by conductometric method using carboxymethylcellulose sodium salt (NaCMC) contained in the tablet. The content of gum arabic and NaCMC in the tablet testifies that the granulate was produced using the “wet granulation” technique which resulted in high hardness of original, esthetic, elliptical tablets and in prolonged disintegration time (erosion).

Conclusions: The used excipients: gum arabic and NaCMC for the production of the tested tablets containing selected dry plant extracts result in their high hardness. The tested dietary supplements are characterized by esthetic design, original shape, and prolonged disintegration time which affects the pharmaceutical availability.

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The effects of flubendazole and its metabolites on the larval development of Haemonchus contortus (Nematoda: Trichostrongylidae): an in vitro study

pharmacokinetics. Acta Tropica, 86: 141–159 http://dx.doi.org/10.1016/S0001-706X(03)00031-7 [5] Dobson, R. J., Griffiths, D. A., Donald, A. D., Waller, P. J. (1987): A genetic model describing the evolution of levamisole resistance in Trichostrongylus colubriformis, a nematode parasite of sheep. IMA J. Appl. Math., 4: 279–293 http://dx.doi.org/10.1093/imammb/4.4.279 [6] Hubert, J., Kerboeuf, D. (1992): A microlarval development assay for the detection of anthelmintic resistance in sheep nematodes. Vet. Rec., 130: 442–446 http

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The effect of herbal materials on the p-glycoprotein activity and function

Pharmacol Exp Ther 2000; 294:88-95. 24. Bilia AR, Gallori S, Vincieri FF. St. John’s wort and depression: efficacy, safety and tolerability - an update. Life Sci 2002; 70:3077-96. 25. Calapai G, Crupi A, Firenzuoli F et al. Serotonin, norepinephrine and dopamine involvement in the antidepressant action of Hypericum perforatum. Pharmacopsych 2001; 34:45-9. 26. Wang Z, Hamman MA, Huang SM, Lesko LJ, Hall SD. Effect of St John‘s wort on the pharmacokinetics of fexofenadine. Clin Pharmacol Ther 2002; 71

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Effect of camellia sinensis extract on the expression level of transcription factors and cytochrome p450 genes coding phase i drug-metabolizing enzymes

. Pharmacokinetics of tea catechins after ingestion of green tea and (-)- epigallocatechin-3 gallate by humans: formation of different metabolites and individual variability. Cancer Epidemiol Biomarkers Prev 2002; 11:1025-1032. 19. Bu-Abbas A, Clifford MN, Walker R, Ioannides C. Selective induction of rat hepatic CYP1 proteins and of peroxisomal proliferation by green tea. Carcinogenesis 1994; 15:2575-2579. 20. Maliakal PP, Coville PF, Wanwimolruk S. Tea consumption modulates hepatic drug metabolizing enzymes in Wistar rats. J Pharm Pharmacol 2001

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SRC kinase mrna transcription changes in testosterone-induced rat ventral prostate lobes under the influence of epilobium angustifolium extract

prostate cancer. J Urol 2008; 179:1235-42. 33. Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M. An overview on 5-α-reductase inhibitors. Steroids 2010; 75:109-153. 34. Azzouni F. Mohler J. Role of 5α-reductase inhibitors in prostate cancer prevention and treatment. Urology 2012; 79(6):1197-205. 35. Gisleskog PO, Hermann D, Hammarlund-Udenaes M, Karlsson MO. The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination. Br J Clin Pharmacol 1999; 47

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Influence of epilobium angustifolium extract on 5α-reductase type 2 and mapk3 kinase gene expression in rats prostates

Mol Biol 1997; 61:55-64. 41. Kang DI, Chung JL. Current status of 5α-reductase inhibitors in prostate disease management. Korean J Urol 2013; 54(4):213-9. 42. Gisleskog PO, Hermann D, Hammarlund-Udenaes M, Karlsson MO. The pharmacokinetic modelling of GI198745 (dutasteride), a compound with parallel linear and nonlinear elimination. Br J Clin Pharmacol 1999; 47:53-8. 43. Stuart JD, Lee FW, Simpson Noel D, Kadwell SH, Overton LK, Hoffman CR, Kost TA, Tippin TK, Yeager RL, Batchelor KW, Bramson HN. Pharmacokinetic

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8-Prenylnaringenin from hop (Humulus lupulus L.) – a panacea for menopause?

. Rad M, Hümpel M, Schaefer O, Schoemaker RC, Schleuning WD, Cohen AF et al. Pharmacokinetics and systemic endocrine effects of the phyto-oestrogen 8-prenylnaringenin after single oral doses to postmenopausal women. Br J Clin Pharmacol 2006; 62(3):288-296. 29. Nilsson S, Kela SM, Treuter E, Tujague M, Thomsen J, Andersson GR et al. Mechanisms of estrogen action. Physiological Reviews 2001; 81(4):1535-1565. 30. van Breemen RB, Yuan Y, Banuvar S, Shulman LP, Qiu X, Alvarenga RF et al. Pharmacokinetics of prenylated hop phenols in women

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Analysis of scopoletin and mangiferin in botanicals and formulations of Shankhpushpi by HPLC

. The determination of scopoletin in environmental tobacco smoke by high-performance liquid chromatography. J Liq Chromatogr 1994; 17(12): 2723-2736. doi: http://dx.doi.org/10.1080/10826079408013410 18. Suryawanshi S, Asthana RK, Gupta RC. Simultaneous estimation of mangiferin and four secoiridoid glycosides in rat plasma using liquid chromatography tandem mass spectrometry and its application to pharmacokinetic study of herbal preparation. J Chromatogr B: Anal Technol Biomed Life Sci 2007; 858: 211–219. doi: http://dx.doi.org/10.1016/j.jchromb.2007

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Clinical and serological study of human alveolar echinococcosis in Slovakia in relation to the outcome of chemotherapy

, M. C., Miguet, J. P. (2000): A 20-year history of alveolar echinococcosis in humans. Analysis of a series of 117 patients from eastern France. Eur. J. Gastroenterol. Hepatol., 12: 327–336 [4] Craig, P. (2003): Echinococcus multilocularis. Curr. Opin. Infect. Dis., 16: 437–444 http://dx.doi.org/10.1097/00001432-200310000-00010 [5] Dayan, A. D. (2003): Albendazole, mebendazole and praziquantel. Review of non-clinical toxicity and pharmacokinetics. Acta Tropica., 86: 141–159 http://dx.doi.org/10.1016/S0001-706X(03

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