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Cristian-Cosmin Strava and Alexandra Mihaela Rusu

. Medicines Compendium (2008). Surrey, UK: Datapharm Communications, [ http://emc.medicines.org/uk/ ]. 12. Rossi S. (2008) Paracetamol. Australian Medicines Handbook. Australian Medicines Handbook. 13. Sawrymowicz M. (1997) The effect of exercise on the pharmacokinetics of acetaminiphen and acetylsalicylic acid. Ann Acad Med Stetin , Vol. 43, p. 57-66. 14. Alexis R. Mauger, Lee Taylor, Christopher Harding, Benjamin Wright, Josh Foster and Paul C. Castle (2014) Acute acetaminophen (paracetamol) ingestion improves time to exhaustion during exercise in

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Șerban Gligor and Răzvan Gligor

P.O. (ed) Endurance in Sport, Blackwell Science, Oxford. 16. Sawrymowicz M. (1997). The effect of exercise on the pharmacokinetics of acetaminophen and acetylsalicylic acid , Ann. Acad.Med. Stetin, 43, 57-66. 17. O’Connor P.J., Cook D.B. (1999). Exercise and pain: the neurobiology, measurement, and laboratory study of pain in relation to exercise in humans , Exerc. Sport Sci. Rev., 27, 119-166. 18. Makin A.J., Williams R. (1997). Acetaminophen-induced hepatotoxicity: predisposing factors and treatments , Adv. Intern. Med., 42, 453

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Vanja Dzambazovska-Trajkovska, Jordan Nojkov, Andrijan Kartalov, Biljana Kuzmanovska, Tatjana Spiroska, Redzep Seljmani, Gjorgji Trajkovski, Nadica Matevska-Geshkovska and Aleksandar Dimovski

brain opioid receptor availability in central and peripheral neuropathic pain. Pain. 2007 Jan; 127(1–2): 183–94. 5. Kerb R. Implications of genetic polymorphisms in drug transporters for pharmacotherapy. Cancer Lett 2006; 234: 4–33. 51. 6. Cascorbi I. Role of pharmacogenetics of ATP-binding cassette transporters in the pharmacokinetics of drugs. Pharmacol Ther 2006; 112: 457–473. 52. 7. Ameyaw MM, Regateiro F, Li T, Liu X, Tariq M, Mobarek A, Thornton N, Folayan GO, Githang’s J, Indalo A, Ofori-Adjei D, Price-Evans DA, McLeod HL. MDR1

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Goce Spasovski

nonadherence. Am J Transplant. 2012; 12(2): 388-99. 22. Vítko S, Ferkl M. Interchangeability of ciclosporin formulations in stable adult renal transplant recipients: comparison of Equoral and Neoral capsules in an international, multicenter, randomized, open-label trial. Kidney Int Suppl. 2010; (115): S12-6. 23. Alloway RR, Sadaka B, Trofe-Clark J, et al. A Randomized Pharmacokinetic Study of Generic Tacrolimus Versus Reference Tacrolimus in Kidney Transplant Recipients. Am J Transplant. 2012; 12(10): 2825-2831. 24. Melilli E

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Satu Tuomainen

. Edginton, A. & Holbrook, J. (2010). A blended learning approach to teaching basic pharmacokinetics and the significance of face-to-face interaction. American Journal of Pharmaceutical Education 74 (5): Article 88. Ellis, R. A. & Goodyear, P. (2010). Students’ experiences of e-learning in higher education . New York and London: Routledge. Flowerdew, L. (2013). Needs analysis and curriculum development in ESP. In B. Paltridge & S. Starfield (Eds.) The handbook of English for specific purposes (pp. 325–346). Malden, MA: John Wiley & Sons Inc

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Ana Filipce, Zorica Naumovska, Aleksandra Kapedanovska Nestorovska, Zoran Sterjev, Katerina Brezovska, Jasmina Tonic-Ribarska, Aleksandra Grozdanova, Ljubica Suturkova and Marija Raleva

, Bravaccio C, Radice S, Capuano A. The predictive value of ABCB1, ABCG2, CYP3A4/5 and CYP2D6 polymorphisms for risperidone and aripiprazole plasma concentrations and the occurrence of adverse drug reactions. Pharmacogenomics J. 2018 May 22; 18(3): 422–430. 4. Vandenberghe F, Guidi M, Choong E, von Gunten A, Conus P, Csajka C, Eap CB. Genetics-Based Population Pharmacokinetics and Pharmacodynamics of Risperidone in a Psychiatric Cohort. Clin Pharmacokinet. 2015 Dec; 54(12): 1259–72. 5. Bork JA, Rogers T, Wedlund PJ, de Leon J. A pilot study on risperidone

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Dragica Zendelovska, Kristina Pavlovska, Emilija Atanasovska, Kalina Gjorgjievska and Marija Petrusevska

REFERENCES 1. Shorvon S, Perucca E, Engel J., Jr. The treatment of epilepsy. 3. UK: Wiley-Blackwell West Sussex; 2009. 2. Sruthi A, Tejaswi P, Thanuja N, Sudheer Kumar D, Vivek Sagar V. Simple RP-HPLC method for estimation of diazepam in tablet dosage form. J Pharm Res 2013; 6(1):140-144 3. Eatman FB, Colburn WA, Boxenbaum HG, Posmanter HN, Weinfeld RE, Ronfeld R, Weissman L, Moore JD, Gibaldi M, Kaplan SA. Pharmacokinetics of diazepam following multiple-dose oral administration to healthy human subjects. J Pharmacokinet Biopharm. 1977; (5

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Zorica Naumovska, Aleksandra K. Nestorovska, Zoran Sterjev, Ana Filipce, Aleksandar Dimovski and Ljubica Suturkova

Res. 2008; 58: 344-347. 12. Uhr M, Grauer MT, Yassouridis A and Ebinger M. Blood- brain barrier penetration and pharmacokinetics of amitriptyline and its metabolites in p-glycoprotein (abcb1ab) knock-out mice and controls. J Psychiatr Res. 2007; 41: 179-188. 13. Gex-Fabry M, Eap CB, Oneda B, Gervasoni N, Aubry JM, Bondolfi G, et al. CYP2D6 and ABCB1 genetic variability: Influence on paroxetine plasma level and therapeutic response. Ther Drug Monit 2008; 30: 474-482. 14. Loscher W and Potschka H. Role of multidrug transporters in pharmacoresistance to

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H. K. Aggarwal, Deepak Jain, Pulkit Chhabra and R. K. Yadav

from kidney disease: improving global outcomes (KDIGO). Kidney Int 2006; 69: 1945-53. 4. Ersoy FF, Passadakis SP, Tam P, Mammos ED, Katopodis PK, Ozener C et al. Bone mineral density and its correlation with clinical and laboratory factors in chronic peritoneal dialysis patients. J Bone Miner Metab 2006; 24(1): 79-86. 5. Lin JH. Bisphosphonates: a review of their pharmacokinetic properties. Bone 1996; 18(2) : 75-85. 6. Rodan GA, Fleisch HA. Bisphosphonates: Mechanisms of action. J Clin Invest 1996; 97: 2692-6. 7. Liberman UA, Weiss SR, Broll J