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Comparison of oral bioavailability of acetaminophen tablets, capsules and effervescent dosage forms in healthy volunteers

.: Pharmacokinetics of paracetamol (acetaminophen) after intravenous and oral administration. Eur J Clin Pharm. 1977;11:283. 9. Srinath K, et al.: Formulation and evaluation of effervescent tablets of paracetamol. INT J Pharm Res Dev. 2011;3:76. 10. Blagden N, et al.: Crystal engineering of active pharmaceutical ingredients to improve solubility and dissolution rates. Adv Drug Deliv Rev 2007 Jul 30;59(7):617-30 Epub 2007 May 29. 11. De Silva L, et al.: Usability of mobile technology to screen for drugdrug interactions in kidney transplant patients. Am J Nephrol

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Rationale for naphazoline effects in-depth study


This article presents a retrospective review of data on side effects of drugs containing naphazoline and data on toxicity of the agent when entered the body via different pathways. Most publications on clinical signs of possible naphazoline-associated side effects are lacking thorough analysis of possible causes. Limited data on the pharmacokinetics and pharmacodynamics of the drug led to various complications after its administration. Therefore, further studies on naphazoline content dynamics or products of its biotransformation in biological substrates and determination of half-life of the agent must be conducted. This will allow establishingsafe levels for different exposure pathways and harmful levels of the naphazoline with respect to its material accumulation. It should be noted that scientific publications contain controversial data regarding allergenic potential of the agent. Possible side effects of the drug on the reproductionand development are not revealed. Determination of effects the products containing naphazoline may have on immune and reproductive system is an important part of the research.

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TLC-densitometric analysis of α-escin in bulk drug substance and in pharmaceutical dosage forms

. 8. Liu, L., et al.: A liquid chromatography-tandem mass spectrometry method for the simultaneous quantification of escin Ia and escin Ib in human plasma: application to a pharmacokinetic study after intravenous administration. Biomed. Chromatogr., 24, 1309-1315, 2010. 9. Man, S.: Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia, 81(7), 703-714, 2010. 10. Rao, A. V, Gurfinkel, D. M.: The bioactivity of saponins: triterpenoid and steroidal glycosides. Drug Metabol Drug Interact., 17(1-4), 211

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Stability indicating HPLC method for the simultaneous determination of dapagliflozin and saxagliptin in bulk and tablet dosage form

Metformin, Journal of Chromatographic Science, 2015;54(1):78-87. 11. Gao JW, Yuan YM, Lu YS, Yao MC. Development of a rapid UPLC-MS/MS method for quantification of saxagliptin in rat plasma and application to pharmacokinetic study, Biomed. Chromatography 2012;26(12):1482-7. 12. Aubry AF, Gu H, Magnier R, Morgan L, Xu X, Tirmenstein M et al. Validated LC–MS/MS methods for the determination of dapagliflozin, a sodium-glucose co-transporter 2 inhibitor in normal and ZDF rat plasma, Bioanalysis, 2010;2(12):2001-9, 2010. 13. Batta N, Pilli NR, Derangula VR

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The effect of one-electron reduced drugs on hepatic aconitase activity and triglycerides level

.K.: Tirapazamine: a novel agent targeting hypoxic tumor cells. Expert Opinion on Investigational Drugs., 18, 77, 2009. 14. Salvatorelli E. et al.: Defective one or two electron reduction of the anticancer anthracycline epirubicin in human heart. Relative importance of vesicular sequestration and impaired efficiency of electron addition. J. Biol. Chem., 281, 10990, 2006. 15. Salvatorelli E. et al.: Pharmacokinetic Characterization of Amrubicin Cardiac Safety in an Ex Vivo Human Myocardial Strip Model. II. Amrubicin Shows Metabolic Advantages over

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Review on analgesic effect of co-administrated ibuprofen and caffeine

contribute to its widespread use. Pharmacol.Rev., 51 (1), 83-133, 1999. 17. Granados-Soto V., Castaneda-Hernandez G.: A review of the pharmacokinetic and pharmacodynamic factors in the potentiation of the antinociceptive effect of nonsteroidal anti-infammatory drugs by caffeine. J. Pharm. Toxicol., 42 (2), 67-72, 1999. 18. Holtzman S.G., Mante S., Minneman K.P.: Role of adenosine receptors in caffeine tolerance. J. Pharmacol. Exp. Ther., 256 (1), 62-68, 1990. 19. Kayrak D., Akman U., Hortacsu O.: Micronization of ibuprofen

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Synergistic interaction of levetiracetam with gabapentin in the mouse 6 Hz psychomotor seizure model – a type II isobolographic analysis

, 2007. 4. Dudra-Jastrzebska M. et al.: Pharmacodynamic and pharmacokinetic interaction profiles of levetiracetam in combination with gabapentin, tiagabine and vigabatrin in the mouse pentylenetetrazole-induced seizure model: an isobolographic analysis. Eur. J. Pharmacol., 605, 87, 2009. 5. Fisher R.S. et al.: ILAE official report: a practical clinical definition of epilepsy. Epilepsia, 55, 475, 2014. 6. Florek-Łuszczki M., Wlaź A., Łuszczki J.J.: Interactions of levetiracetam with carbamazepine, phenytoin, topiramate and

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Desloratadine analysis: as a pharmaceutical preparation and after accelerating ageing

2013. 7. Mohamed G.G., Abou Attia F.M., Ibrahim N.S.: Development and validation of spectrophotometric and HPLC methods for the determination of desloratadine in tablets and syrup. J. Pharm. Res. 5(5), 2799, 2012. 8. Polish Farmacopeia IX, Polish Pharmaceutical Society, Warsaw, 2011. 9. Ponnuru V.S, Challa B.R., Nadendla R.: Quantification of desloratadine in human plasma by LC-ESI-MS/MS and application to a pharmacokinetic study. J. Pharm. Anal. 2(3), 180, 2012. 10. Rele R.V., Gurav P.J.: A Simple

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Modern kinetic spectrophotometric procedure for estimation of furosemide drug as bulk form and in pharmaceuticals preparations

REFERENCES 1. Abdel-Hamid M.E.: High-performance liquid chromatograghy – mass spectrometric analysis of furosemide in plasma and its use in pharmacokinetic studies. Farmaco , 55, 448, 2000. 2. Abdul Satar R.S. (2006). Development of new spectrophotometric methods for determination of some organic drug compounds in pharmaceutical preparations . “Ph. D. Thesis”, Baghdad University”. 3. Al-Enizzi M.S.: Spectrophotometric method for Assay of Salbutamol in Pharmaceutical Formulations. Tikrit J. of Pure Science , 13(2), 90, 2008. 4. Al

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Flozins, inhibitors of type 2 renal sodium-glucose co-transporter – not only antihyperglycemic drugs

sodium glucose co-transporter 2 inhibitor. Postgrad. Med., 126, 7, 2014. 17. Plosker G.: Canagliflozin: a review of its use in patients with type 2 diabetes mellitus. Drugs, 74, 807, 2014. 18. Reilly T. et al.: Carcinogenicity risk assessment supports the chronic safety of dapagliflozin, an inhibitor of Sodium-Glucose Co-Transporter 2, in the treatment of type 2 diabetes mellitus. Diabetes Ther., 5, 73, 2014. 19. Scheen A.: Evaluating SGLT2 inhibitors for type 2 diabetes: pharmacokinetic and toxicological considerations

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