times for pharmacokinetic experiments, Journal of Pharmacokinetics and Biopharmaceutics 9 (6): 739-756. de Jong, H. (2002). Modeling and simulation of genetic regulatory systems: A literature review, Journal of Computational Biology 9 (1): 67-103. DiStefano, J. J. (1981). Optimized blood sampling protocols and sequential design of kinetic experiments, American Journal of Physiology 9 (240): R259-R265. Fedorov, V. V. (1972). Theory of Optimal Experiments , Academic Press, New York
Carmen Coll and Elena Sánchez
Press, Cambridge, MA. Verdière, N., Denis-Vidal, L., Joly-Blanchard, G. and Domurado, D. (2005). Identifiability and estimation of pharmacokinetic parameters for the ligands of the macrophage mannose receptor, International Journal Applied Mathematics and Computer Science 15 (4): 517–526.
Clara Rojas and Juan Belmonte-Beitia
cytotoxic agents to increase the selectivity of therapy. Reference [ 46 ] models the proliferation cycle of leukemia. Eisen [ 14 ] also gives some introductory discussion of cell-cycle specific chemotherapy and compartmental models (distinguishing between proliferating and quiescent cells), but mostly in the context of pharmacokinetics and clearly the emphasis is more on modeling than on analysis. After that, a great effort was done to study the development and analysis of compartmental models which describe and analyze the actions of drugs on specific compartments from
Víctor M. Pérez-García, Susan Fitzpatrick, Luis A. Pérez-Romasanta, Milica Pesic, Philippe Schucht, Estanislao Arana and Pilar Sánchez-Gómez
, also applicable to cancer. They claim that the mention of population analysis or pharmacokinetic and pharmacodynamic (PKPD) modelling often sends clinicians and clinical pharmacologists running, not wanting to know about mathematics and understanding complexity. Individualized dosing, optimal design of studies and mechanistic models of physiological processes are all ‘too hard’ . Our modern society relies on advanced technology, but we only apply it as common users (ie, GPS) and not struggling to understand it. If we want to advance, some clinicians need involved