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Piotr Boguta, Dariusz Juchnowicz, Paulina Wróbel-Knybel, Agnieszka Biała-Kędra and Hanna Karakuła-Juchnowicz

, Mancuso A, Andò G, et al. Pharmacokinetics of new oral anticoagulants: implications for use in routine care. Expert Opin Drug Metab Toxicol. 2018; 14:1057-1069. 5. Dexxience [EU]. BevyxXa [US] · Venous thromboemolism (VTE) prevention - first line - in at risk adult patients hospitalised for an acute medical illness [Cited 13.01.2019]. Accessible at: https://www.sps.nhs.uk/medicines/betrixaban/ 6. Gelosa P, Castiglioni L, Tenconi M, Baldessin L, Racagni G, Corsini A, et al. Pharmacokinetic drug interactions of the non-vitamin K antagonist oral anticoagulants

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Agnieszka Pedrycz and Agnieszka Kramkowska

): 270-281. 8. Wcisło G., Korniluk J., Szarlej-Wcisło K., Pawlak W.Z., Nurzyński P., Duchnowska R.: Leczenie chorób nowotworowych czynnikiem martwicy nowotworów – alfa (TNF-alfa). Współczesna Onkologia, 2002; 4: 222–227. 9. Gabizon et al . Pharmacokinetics of Pegylated Liposomal Doxorubicin Review of Animal and Human Studies. Clin Pharmacokinet 2003; 42 (5): 419-436. 10. National Institute for Health and Clinical Excellence; TA91 Ovarian cancer (advanced) - paclitaxel, pegylated liposomal doxorubicin hydro-chloride and topotecan (review): Guidance

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Matej Stuhec and Jordi Serra-Mestres

to add that there are few possibilities that the inhibition of any single isoform could cause clinically significant changes in the pharmacokinetics of sertraline ( Obach et al. 2005 ). These important pharmacokinetic properties of sertraline show that it has a small number of possible clinically important DDIs in real clinical practice. Despite the fact that these pharmacokinetic properties are important, it is clear that sertraline cannot be used in all older patients on polypharmacy because antidepressants have different mechanisms of action that are very