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Changes in Some Pharmacokinetics Parameters of Chloroquine by Gnetum Africana

chloroquine sulphate and aqueous extract of Azadirachta indica A Juss (Meliaceae) in rabbits. Acta Pharmaceutica. 2003;53(4):305-11. 8. O’Brien D, Haddad AR. Consulting patients on drug-food interactions. U. S. Pharmacist. 2002;22(6). 9. Eseyin OA, Edoho EJ, Igboasoiyi AC, Nwadiukwu E, Ekpo A. Effects of the leaf extract of Telfairia occidentalis on the pharmacokinetic of chloroquine. International Journal of Biological Chemistry. 2007;1(4):256-260. 10. Igboasoiyi AC, Eseyin OA, Udoma NF. The effect of ethanolic extract of

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Simultaneous Determination of Carbamazepine and Carbamazepine-10,11-epoxide in Different Biological Matrices by LC-MS/MS

carbamazepine in serum and saliva samples by high performance liquid chromatography with ultraviolet detection Odre đ ivanje karbamazepina u uzorcima seruma i salive primenom te č ne hromatografije visokih performansi sa ultravioletnom de. Vojn Pregl . 2009;66:347-352. 18. Krasowski MD, McMillin GA. Advances in anti-epileptic drug testing. Clin Chim Acta . 2014;436:224-236. 19. Beig A, Dahan A. Quantification of carbamazepine and its 10,11-epoxide metabolite in rat plasma by UPLC-UV and application to pharmacokinetic study. Biomed Chromatogr . 2014

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Steroid pharmacokinetics: An “overlooked” issue of steroid metabolism in acute and chronic disease

References 1. Sefar S, Degoricija V. About drug dialyzability. Acta Clin Croat 2003;42:257-26. 2. Al-Habet SM, Rogers HJ. Methylprednisolone pharmacokinetics after intravenous and oral administration. Br J Clin Pharmacol 1989;27:285-90. 3. Venkatesh B, Myburgh J, Finfer S, Webb SA, Cohen J, Bellomo R, et al. The ADRENAL study protocol: Adjunctive corticosteroid treatment in critically ill patients with septic shock. Crit Care Resusc 2013;15:83-8. 4. Frey BM, Frey FJ. Clinical pharmacokinetics of

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Treatment of ventilator-associated pneumonia with high-dose colistin under continuous veno-venous hemofiltration

the 1970s because of significant renal and neurological toxicity. [ 4 ] At present, COL is increasingly put forward as salvage or first-line treatment for severe MDR-GNB infections, particularly in the ICU. [ 5 ] COL is administered intravenously as the inactive prodrug colistimethate sodium (CMS) that is hydrolyzed to COL. From a pharmacodynamic/pharmacokinetic (PK/PD) viewpoint, COL possesses rapid concentration-dependent bacterial killing against susceptible strains, but the ratio of the area under the concentration time curve of the unbound fraction to the

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Experimental Study of the New Non-Opioid Analgesic Pyrodazol and Ketorolac in the Rats

Pharmacology of (R)- and (S)- Ketorolac. J Clin Pharmacol. 1998; 38: 25-35. 8. King TE, Joynes RL, Grau JW Tail-flick test: II. The role of supraspinal systems and avoidance learning. Behav Neurosci . 1997;111:754-767. 9. Komlos E, Porsresr J, Knole J.Morfin - prostigmin synergismus. Az. Acta. Phisiologica. Acad. Scient. Hungaricae.-1950;1: 77-83. 10. Lugo RA, Kern SE. Clinical pharmacokinetics of morphine. J. Pain Palliat Care Pharmacother. 2002; 16(4): 5-18. 11. Mathias SD, Kuppermann M, Liberman RF, Lipschutz

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Parasitaemia Changes in the Course of Treatment of Severe Malaria Patients with Artemether and Quinine (A Preliminary Study)

White NJ. Clinical pharmacokinetics of antimalarial drugs. Clin Pharmacokinet. 1985;10(3):187-215. doi:10.2165/00003088-198510030-00001 PMID:3893840 Hosein S. Infection fighters - Artemisia - experience. Treatment information Exchange. Canada Update 60. Vol 7.

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Heroin Maintenance Treatment - Are the Further Investigation Needed?

Report 2010. http:// www.emcdda.europa.eu/events/2010/annual-report. 29. Farrell M. National Addiction Centre, Institute of Psychiatry, London SE5 8AF Wayne Hall. The Swiss heroin trials: testing alternative approaches BMJ. 1998;316(7132): 639. 30. Carnwath T, Merrill J. Dose equivalents in opioid substitution treatment. International Journal of Drug Policy. 2002;13:445-447. 31. Rook EJ, Huitema AD, van den Brink W, van Ree JM, Beijnen JH. Pharmacokinetics and pharmacokinetic variability of heroin and its metabolites

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Efficacy and Tolerability of Various Antimicrobial Regimens in the Treatment of Exacerbations of Chronic Bronchitis and Chronic Obstructive Pulmonary Disease in Outpatients

chronic obstructive pulmonary disease after treatment with antimicrobials: a results of a two-years study. IMPAC Study Group. Clin Drug Invest. 2003;23:439-450. doi:10.2165/00044011-200323070-00003 PMID:17535055 Perry CM, Brogden RN. Cefuroxime Axetil. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1996;52(1):125-156. doi:10.2165/00003495-199652010-00009 PMID:8799689 Destache CJ, Dewan N, O'Donohue WJ, et al. Clinical and economic considerations in the

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Quantitative Analysis of Adrenal Cortical Histological Alterations After Application of Medroxyprogesterone Acetate

;3(2):123-131. Blossey HC, Wander HE, Koebberling J, Nagel GA, Pharmacokinetic and pharmacodynamic basis for the treatment of metastatic breast cancer with high-dose medroxyprogesterone acetate. Cancer. 1984;54:1208-1215. Van Veelen H, Willemse PH, Sleijfer DT, Van der Ploeg E, Sluiter WJ, Doorenbos H. Mechanism of adrenal suppresion by high-dose medroxy-progesterone acetate in breast cancer patients. Cancer Chemother Pharmacol. 1985;15(2):167-170. Barbieri RL, Ryan KJ. Direct effects of medroxyprogesterone acetate (MPA) and

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Vitamin C dosing during continuous renal replacement therapy: The last word is not said!

To the editor Pharmacokinetic and dose-response data suggest a vitamin C (vit C) dose largely exceeding 3 g daily in critically ill patients. We recently proposed higher vit C dosing in cardiac arrest patients who require continuous renal replacement therapy (CRRT).[ 1 ] In a reaction, Spoelstra-de Man et al . rebutted that increasing the vit C dose above 2 g/day during continuous veno-venous hemofiltration (CVVH) was unnecessary when normal plasma vit C concentrations are targeted. They based their standpoint on calculating less vit C removal during CVVH

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