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Renal Changes in Cocaine Abuse and Addiction

, Day RO. Pharmacokinetic and pharmacodynamic principles of illicit drug use and treatment of illicit drug users. Clin Pharmacokinet 1997;33(5):344-400. 5. Nestler EJ. The neurobiology of cocaine addiction. Sci Pract Perspect 2005;3(1):4-10. 6. Volkow ND, Morales M. The brain on drugs: from reward to addiction. 2015;Cell 162:712–725. 7. Robison AJ, Nestler EJ. Transcriptional and epigenetic mechanisms of addiction. Nat Rev Neurosci 2011;12(11):623-637. 8. Buettner M, Toennes SW, Buettner S, et al. Nephropathy in illicit drug dbusers: a

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Basic Mechanisms of Action of the Antiepileptic Drugs

action, pharmacokinetics and interactions. Pharmacology Reports 2009;61;2:197-216. 23. Mantegazza M, Curia G, Biagini G, et al. Voltage-gated sodium channels as therapeutic targets in epilepsy and other neurological disorders. Lancet Neurol 2010;9:413-424. 24. Meldrum BS, Rogawski MA. Molecular targets for antiepileptic drug development. Neurotherapeutics: The Journal of the American Society for Experimental Neurotherapeutics 2007;4:18-61. 25. Miceli F, Soldovieri MV, Ambrosino Pet al. Early-onset epileptic encephalopathy caused by gain

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The Heparanase Inhibitor (Sulodexide) Decreases Urine Glycosaminoglycan Excretion and Mitigates Functional and Histological Renal Damages in Diabetic Rats

pharmacodynamics, pharmacokinetics, and therapeutic properites of sulodexide. Med Res Rev. 1998;18(1):1-20. 15. Dedov I, Shestakova M, Vorontzov A, Palazzini E. A randomized, controlled study of sulodexide therapy for the treatment of diabetic nephropathy. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association-European Renal Association. 1997;12(11):2295-300. 16. Skrha J, Perusicová J, Pont’uch P, Oksa A. Glycosaminoglycan sulodexide decreases albuminuria in diabetic patients. Diabetes Res Clin Pract. 1997

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EU Paediatric Investigation Plans (Pips) Might Harm Children

References 1. Adamson PC. Improving the outcome for children with cancer: development of targeted new agents. CA Cancer J Clin. 2015;65: 212-220. 2. A Phase I/II, Multicenter, Open-Label, Dose-Escalation Study Of The Safety And Pharmacokinetics Of Cobimetinib In Pediatric And Young Adult Patients With Previously Treated Solid Tumors. Accessed 20JAN2017. 3. A Study of Pembrolizumab (MK-3475) in Pediatric Participants With Advanced

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