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Sofiya Ivanova, Dimitrichka Dimitrova and Metodi Petrichev

). Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs. Veterinary Quarterly 10, 156-163. PMid:3176294 7. Walker, R.D., Stein, G.E., Hauptman, J.G., MacDonald, K.H., Budsberg, S.C., Rosser, E.J.Jr. (1990). Serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs. American Journal of Veterinary Research 51, 896-900. 8. Parikh, V., Shivprakash, K., Patel, D., Gandhi, T

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Natalia Francisca Urzúa Pizarro, Carlos Alberto Errecalde, Guillermo Fermin Prieto, Carlos Fernando Lüders, María Paula Tonini and Eduardo Jesús Picco

., Wang, L., Shen, X., Gu, X., Zeng, D., Zeng, Z. (2013). Plasma and tissue pharmacokinetics of marbofloxacin in experimentally infected chickens with Mycoplasma gallisepticum and Escherichia coli. J. Vet. Pharmacol. Ther. 36, 511-515. PMid:23550715 5. El-Komy, A., Attia, T., El Latif, A., Fathy, H. (2016). Bioavailability pharmacokinetics and residues of marbofloxacin in normal and E. coli infected broiler chicken. In. J. Pharmacol. Tox. 2 (4): 144-149. 6. Huang, X., Chen, Z., Zhang, S., Zeng, Z. (2003). Influence of

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Neno Bratoev, Aneliya Milanova, Ivelina Pavlova and Lubomir Lashev

REFERENCES 1. Pijpers, A., Van Klingeren, B., Schoevers, E.J., Verheijden, J.H.M., Van Miert, A.S. (1989). In vitro activity of five tetracyclines and some other antimicrobial agents four porcine respiratory tract pathogens. J. Vet. Pharmacol. Ther. 12, 267–276. PMid:2810475 2. Anadón, A., Martínez-Larra-aga, M.R., Diaz, M.J., Bringas, P., Fernandez, M.C., Fernandez-Cruz, M.L., Iturbe, J., Martínez, M.A. (1994). Pharmacokinetics of doxycycline in broiler chickens. Avian Pathol. 23, 79-90. http

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Dimitrichka Dimitrova, Anna Arnaudova-Matey, Petar Dilov, Geno Angelov, Tandju Mehmedov, Toni Todorov, Denka Kushvalieva, Dimitrina Nikolova and Valija Dilova

References 1. Geisser, P., Burckhardt, S. (2011). The Pharmacokinetics and Pharmacodynamics of Iron preparations. Pharmaceutics, 3(1): 12-33. 2. Egli, A. K., Franstad, T., Gramingen, D. (1998). The effect of per oral administration of aminoacid chelated iron to pregnant sows in prevention sow and piglet anemia. Acta Veterinaria Scandinavica 39(1): 77-87. 3. Andrews, N. C. (1999). Disorders of iron metabolism. The New England Journal of Medicine 341, 1986-1995. 4. Kalantaz-Zadeh, K. E., Steja, E

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DD Milovanovic, JR Milovanovic, M Radovanovic, I Radosavljevic, S Obradovic, S Jankovic, D Milovanovic and N Djordjevic

Introduction Carbamazepine belongs to the older generation of anticonvulsants, which is almost completely metabolized in the liver through processes that involve several liver enzymes, including CYP2C8 [ 1 - 4 ]. To date, there are 16 different CYP2C8 alleles described ), most of them associated with altered enzyme activity [ 5 ]. Although genes could affect the drug metabolism there is a general lack of evidence of influence of CYP2C8 genetic variations on carbamazepine pharmacokinetics, especially in children [ 6

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Suvatna Chulavatnatol, Kumthorn Malathum, Sasisopin Kiertiburanakul, Kittisak Sripha and Pojawon Lawanprasert

. Single-dose pharmacokinetics of indinavir and the effect of food. Antimicrob Agents Chemother. 1998; 42:332-8. 5. Hsu A, Granneman GR, Cao G, Carothers L, Japour A, El-Shourbagy T, et al. Pharmacokinetic interaction between ritonavir and indinavir in healthy volunteers. Antimicrob Agents Chemother. 1998; 42:2784-91. 6. The United States Pharmacopoeial Convention, Inc. The United States Pharmacopeia 26 / National Formulary 21. Rockville, USA; 2003. 7. Drug Control Division. Thailand Guidelines for the Conduct of

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Monchana Jullangkoon, Sutep Jaruratanasirikul and Nanchanit Aeinlang

References 1. Mutnick AH, Rhomberg PR, Sader HS, Jones RN. Antimicrobial usage and resistance trend relationships from the MYSTIC Programme in North America (1999-2001). J Antimicrob Chemother. 2004; 53:290-6. 2. Barradell LB, Bryson HM. Cefepime: a review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1994; 47:471-505. 3. Yahav D, Paul M, Fraser A, Sarid N, Leibovici L. Efficacy and safety of cefepime: a systematic review and meta-analysis. Lancet Infect Dis. 2007; 7

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Valon Krasniqi, Aleksandar Dimovski, Iva Klarica Domjanović, Ivan Bilić and Nada Božina

R-, S- and racemic ibuprofen. J Pharmacol Exp Ther 1991;259:1133-9. PMID: 1762067 10. Woodman TJ, Wood PJ, Thompson AS, Hutchings TJ, Steel GR, Jiao P, Threadgill MD, Lloyd MD. Chiral inversion of 2-arylpropionyl-CoA esters by human α-methylacyl-CoA racemase 1A (P504S): a potential mechanism for the anticancer effects of ibuprofen. Chem Commun (Camb) 2011;47:7332-4. doi: 10.1039/c1cc10763a 11. Davies NM. Clinical pharmacokinetics of ibuprofen. The first 30 years. Clin Pharmacokinet 1998;34:101-54. doi: 10

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Maja Katalinić, Nikolina Maček Hrvat, Jana Žďárová Karasová, Jan Misik and Zrinka Kovarik

;154:169-76. doi: 10.1113/jphysiol.1960.sp006571 16. Saxena A, Sun W, Luo C, Myers TM, Koplovitz I, Lenz DE, Doctor BP. Bioscavenger for protection from toxicity of organophosphorus compounds. J Mol Neurosci 2006;30:145-7. doi: 10.1385/JMN:30:1:145 17. Thiermann H, Eyer F, Felgenhauer N, Pfab R, Zilker T, Eyer P, Worek F. Pharmacokinetics of obidoxime in patients poisoned with organophosphorus compounds. Toxicol Lett 2010;197:236-42. doi: 10.1016/j.toxlet.2010.06.005 18. Lenz DE, Maxwell DM, Koplovitz I, Clark CR, Capacio BR

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Abbas Aghabiklooei, Shahin Shadnia, Hossein Hassanian-Moghaddam and Nasim Zamani

References 1. Anggard E, Nilsson MI, Holmstrand J, Gunne LM. Pharmacokinetics of methadone during maintenance therapy: pulse labeling with deuterated methadone in the steady state. Eur J Clin Pharmacol 1979;16:53-7. PMID: 499301 2. Corkery JM, Schifano F, Ghodse AH, Oyefeso A. The effects of methadone and its role in fatalities. Hum Psychopharmacol 2004;19:565-76. doi: 10.1002/hup.630 3. Hendra TJ, Gerrish SP, Forrest AR. Fatal methadone overdose. BMJ 1996;313:481-2. doi: 10.1136/ bmj.315.7099.55a