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A. Jasiecka, T. Grabowski, T. Maślanka, H. Ziółkowski and J.J. Jaroszewski

129: 1010-1019. FDA and CDER. Guidance for Industry: Bioanalytical Method Validation. US Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research: Rockville, MD ( 2001 ). Jang SB, Lee YJ, Lim LA, Park KM, Kwon BJ, Woo JS, Kim YI, Park MS, Kim KH, Park K ( 2010 ) Pharmacokinetic comparison of controlled-release and immediate-release oral formulations of simvastatin in healthy Korean subjects: a randomized, open-label, parallel-group, singleand multiple-dose study. Clin Ther 32: 206

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Sofiya L. Ivanova, Dimitrichka J. Dimitrova, Metodi H. Petrichev, Liliana I. Parvanova, Georgi Sl. Kalistratov and Lubomir T. Vezenkov

.0. Pharmacokinetic and Pharmacodynamic Data Analysis System for PC. Stuttgart, Jena, New York: Gustav Fisher; 1993. 18. Baggot DJ. The Physiological Basis of Veterinary Clinical Pharmacology. Oxford (UK): Blackwell Science Ltd; 2001. 19. Gibaldi M, Perrier D. Pharmacokinetics, Revised and Expanded. 2nd ed. Swarbrick J, editor. New York: Informa Healthcare Inc; 2007. 20. Yamaoka K, Nakagawa T, Uno T. Application of Akaike’s Information Criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacokinet Biopharm. 1978;6:166-75. 21. Ivanova

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Henri Astroug, Roumiana Simeonova, Lilia Kassabova, Nikolay Danchev and Dobrin Svinarov

derivatives and of bioisosteric thiocytisine as potent and selective nAChR ligands. Eur J Med Chem   36 : 375-388. Jorenby D, Hays J, Rigotti N, Azoulay S, Watsky E, Williams K, Billing C, Gong J and Reeves K. (2006). Efficacy of varenicline, an α 4 β 2 -nicotinic acetylcholine receptor partial agonist, vs. placebo or sustained-release bupropion for smoking cessation. A randomized controlled trial. JAMA   296 : 56-63. Klocking H, Richter M, and Damm G. (1980). Pharmacokinetic studies with 3 Hcytisine. Arch Toxicol

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Sofiya Ivanova, Dimitrichka Dimitrova and Metodi Petrichev

). Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs. Veterinary Quarterly 10, 156-163. https://doi.org/10.1080/01652176.1988.9694165 PMid:3176294 7. Walker, R.D., Stein, G.E., Hauptman, J.G., MacDonald, K.H., Budsberg, S.C., Rosser, E.J.Jr. (1990). Serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs. American Journal of Veterinary Research 51, 896-900. 8. Parikh, V., Shivprakash, K., Patel, D., Gandhi, T

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Lenard Farczadi, Laurian Vlase, Orsolya Melles, Ramona Tolomeiu, Octavia Tamas-Krumpe, Andreea Buta and Laurentiu Ognean

References 1. Barrera B, Otero JA, Egido E et al. The Anthelmintic Triclabendazole and Its Metabolites Inhibit the Membrane Transporter ABCG2/BCRP. Antimicrob Agents Chemother 2012; 56(7): 3535-3543. 2. Halferty L, Brennan GP, Trudgett A, Hoey L, Fairweather I. Relative activity of triclabendazole metabolites against the liver fluke, Fasciola hepatica. Vet Parasitol 2009; 159:126–138. 3. González Canga A, Sahagún Prieto AM, José Diez Liébana M, Martínez NF, Vega MS, Vieitez JJ. The pharmacokinetics and metabolism of ivermectin in domestic animal

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Natalia Francisca Urzúa Pizarro, Carlos Alberto Errecalde, Guillermo Fermin Prieto, Carlos Fernando Lüders, María Paula Tonini and Eduardo Jesús Picco

., Wang, L., Shen, X., Gu, X., Zeng, D., Zeng, Z. (2013). Plasma and tissue pharmacokinetics of marbofloxacin in experimentally infected chickens with Mycoplasma gallisepticum and Escherichia coli. J. Vet. Pharmacol. Ther. 36, 511-515. https://doi.org/10.1111/jvp.12049 PMid:23550715 5. El-Komy, A., Attia, T., El Latif, A., Fathy, H. (2016). Bioavailability pharmacokinetics and residues of marbofloxacin in normal and E. coli infected broiler chicken. In. J. Pharmacol. Tox. 2 (4): 144-149. 6. Huang, X., Chen, Z., Zhang, S., Zeng, Z. (2003). Influence of

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Neno Bratoev, Aneliya Milanova, Ivelina Pavlova and Lubomir Lashev

REFERENCES 1. Pijpers, A., Van Klingeren, B., Schoevers, E.J., Verheijden, J.H.M., Van Miert, A.S. (1989). In vitro activity of five tetracyclines and some other antimicrobial agents four porcine respiratory tract pathogens. J. Vet. Pharmacol. Ther. 12, 267–276. http://dx.doi.org/10.1111/j.1365-2885.1989.tb00670.x PMid:2810475 2. Anadón, A., Martínez-Larra-aga, M.R., Diaz, M.J., Bringas, P., Fernandez, M.C., Fernandez-Cruz, M.L., Iturbe, J., Martínez, M.A. (1994). Pharmacokinetics of doxycycline in broiler chickens. Avian Pathol. 23, 79-90. http

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R. Sokół, M. Raś-Noryńska, M. Michalczyk, A. Jasiecka, H. Ziółkowski and J. Jaroszewski

-21. Demeulenaere D, Vercruysse J, Dorny P, Claerebout E ( 1997 ) Comparative studies of ivermectin and moxidectin in the control of naturally acquired cyathostome infections in horses. Vet Rec 141: 383-386. Drudge JH, Lyons ET ( 1989 ) Internal parasites of equids with emphasis on treatment and control. (Revision) Monopgraph, Hoechest-Roussel Agri-Vet, Somerville, NJ, p 26. Dupuy J, Yin H, Luo JX, Yang DY, Guan GQ, Ma ML, Sutra JF, Lespine A, Boulard C, Alvinerie M ( 2003 ) Pharmacokinetics of ivermectin in the yak ( Bos grunniens ). Vet Parasitol 117: 153

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Dimitrichka Dimitrova, Anna Arnaudova-Matey, Petar Dilov, Geno Angelov, Tandju Mehmedov, Toni Todorov, Denka Kushvalieva, Dimitrina Nikolova and Valija Dilova

References 1. Geisser, P., Burckhardt, S. (2011). The Pharmacokinetics and Pharmacodynamics of Iron preparations. Pharmaceutics, 3(1): 12-33. 2. Egli, A. K., Franstad, T., Gramingen, D. (1998). The effect of per oral administration of aminoacid chelated iron to pregnant sows in prevention sow and piglet anemia. Acta Veterinaria Scandinavica 39(1): 77-87. 3. Andrews, N. C. (1999). Disorders of iron metabolism. The New England Journal of Medicine 341, 1986-1995. 4. Kalantaz-Zadeh, K. E., Steja, E

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Olorunfemi Eseyin, Aniekan Ebong, Anefiok Ubobre, Johnson Ekarika and Imo Udo

chloroquine sulphate and aqueous extract of Azadirachta indica A Juss (Meliaceae) in rabbits. Acta Pharmaceutica. 2003;53(4):305-11. 8. O’Brien D, Haddad AR. Consulting patients on drug-food interactions. U. S. Pharmacist. 2002;22(6). 9. Eseyin OA, Edoho EJ, Igboasoiyi AC, Nwadiukwu E, Ekpo A. Effects of the leaf extract of Telfairia occidentalis on the pharmacokinetic of chloroquine. International Journal of Biological Chemistry. 2007;1(4):256-260. 10. Igboasoiyi AC, Eseyin OA, Udoma NF. The effect of ethanolic extract of