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Pharmacokinetics of Ciprofloxacin in Broiler Chickens After Single Intravenous and Intraingluvial Administration

). Pharmacokinetics, renal clearance and metabolism of ciprofloxacin following intravenous and oral administration to calves and pigs. Veterinary Quarterly 10, 156-163. https://doi.org/10.1080/01652176.1988.9694165 PMid:3176294 7. Walker, R.D., Stein, G.E., Hauptman, J.G., MacDonald, K.H., Budsberg, S.C., Rosser, E.J.Jr. (1990). Serum and tissue cage fluid concentrations of ciprofloxacin after oral administration of the drug to healthy dogs. American Journal of Veterinary Research 51, 896-900. 8. Parikh, V., Shivprakash, K., Patel, D., Gandhi, T

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Pharmacokinetic Behavior of Marbofloxacin in Plasma from Chickens at Different Seasons

., Wang, L., Shen, X., Gu, X., Zeng, D., Zeng, Z. (2013). Plasma and tissue pharmacokinetics of marbofloxacin in experimentally infected chickens with Mycoplasma gallisepticum and Escherichia coli. J. Vet. Pharmacol. Ther. 36, 511-515. https://doi.org/10.1111/jvp.12049 PMid:23550715 5. El-Komy, A., Attia, T., El Latif, A., Fathy, H. (2016). Bioavailability pharmacokinetics and residues of marbofloxacin in normal and E. coli infected broiler chicken. In. J. Pharmacol. Tox. 2 (4): 144-149. 6. Huang, X., Chen, Z., Zhang, S., Zeng, Z. (2003). Influence of

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Pharmacokinetics of Doxycycline in Ducks with Steatosis due to Force-feeding

REFERENCES 1. Pijpers, A., Van Klingeren, B., Schoevers, E.J., Verheijden, J.H.M., Van Miert, A.S. (1989). In vitro activity of five tetracyclines and some other antimicrobial agents four porcine respiratory tract pathogens. J. Vet. Pharmacol. Ther. 12, 267–276. http://dx.doi.org/10.1111/j.1365-2885.1989.tb00670.x PMid:2810475 2. Anadón, A., Martínez-Larra-aga, M.R., Diaz, M.J., Bringas, P., Fernandez, M.C., Fernandez-Cruz, M.L., Iturbe, J., Martínez, M.A. (1994). Pharmacokinetics of doxycycline in broiler chickens. Avian Pathol. 23, 79-90. http

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Comparative Study of the Pharmacokinetics of Inorganic and Organic Iron Compounds in Broiler Chickens

References 1. Geisser, P., Burckhardt, S. (2011). The Pharmacokinetics and Pharmacodynamics of Iron preparations. Pharmaceutics, 3(1): 12-33. 2. Egli, A. K., Franstad, T., Gramingen, D. (1998). The effect of per oral administration of aminoacid chelated iron to pregnant sows in prevention sow and piglet anemia. Acta Veterinaria Scandinavica 39(1): 77-87. 3. Andrews, N. C. (1999). Disorders of iron metabolism. The New England Journal of Medicine 341, 1986-1995. 4. Kalantaz-Zadeh, K. E., Steja, E

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Development of a UHPLC-MS/MS method for the determination of quercetin in milk and its application to a pharmacokinetic study

References 1. de Boer V.C., Dihal A.A., van der Woude H., Arts I.C., Wolffram S., Alink G.M., Rietjens I.M., Keijer J., Hollman P.C.: Tissue distribution of quercetin in rats and pigs. J Nutrit 2005, 135, 1718–1725. 2. Chang L., Ren Y., Cao L., Sun Y., Sun Q., Sheng N., Yuan L., Zhi X., Zhang L.: Simultaneous determination and pharmacokinetic study of six flavonoids from Fructus Sophorae extract in rat plasma by LC–MS/MS. J Chrom B 2012, 904, 59–64. 3. Coppin J.P., Xua Y., Chena H., Pan M.H., Hoc Ch.T., Juliani R., Simon J.E., Wu Q

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Withdrawal of amoxicillin and penicillin G procaine from milk after intramammary administration in dairy cows with mastitis

References 1. Bengtsson B., Jacobsson S.O., Luthman J., Franklin A.: Pharmacokinetics of penicillin-G in ewes and cows in late pregnancy and in early lactation. J Vet Pharmacol Ther 1997, 20, 258–261. 2. Błądek T, Posyniak A, Gajda A, Gbylik M, Żmudzki J.: Multi-class procedure for analysis of antibacterial compounds in animal tissues by liquid chromatography tandem mass spectrometry. Bull Vet Inst Pulawy 2011, 55, 741–748. 3. Bruno F., Curini R., di Corcia A., Nazzari M., Samperi R.: Solid-phase extraction followed by liquid chromatography

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Pharmacokinetic - pharmacodynamic model and ampicillin residue depletion after intramammary administration in cows

., Marosevic D., Jaglic Z.: Prevalence of mastitis pathogens in milk from clinically healthy cows. Med Weter 2013, 58, 567–575. 4. Christensen J.M., Smith B.B., Murdena S.B., Hollingshead N.: The disposition of five therapeutically important antimicrobial agents in llamas. J Vet Pharmacol Ther 1996, 19, 43–438. 5. Concordet D., Toutain P.L.: The withdrawal time estimation of veterinary drugs revisited. J Vet Pharmacol Ther 1997, 20, 380–386. 6. Craigmill A.L., Pass M.A., Wetzlich S.: Comparative pharmacokinetics of AMX administered intravenously to sheep

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Changes in erythrocyte membrane permeability induced by verapamil, chlorpromazine, and their combinations with amphotericin B

-321. McTavish D., Sorkin D. 1989. Verapamil: an update review of its pharmacodynamic and pharma-cokinetic properties and therapeutic use in hypertension. Drugs 38: 19-76. Meier M., Li Blatter X., Seelig A., Seelig J. 2006. Interaction of verapamil with lipid membranes and P-glycoprotein: connecting thermodynamics and membrane structure with functional activity. Biophys. J. 91: 2943-2955. Michalak K., Wesołowska O., Motohashi N., Hendrich A. B. 2007. The role of the membrane actions of phenotiazines and flavonoids as

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Morphological and pharmacokinetic properties of oral solid dietary supplements containing plant extracts

Summary

Introduction: Dietary supplements are a good way to supplement the deficiency of certain micronutrients and organic components (therapeutic agents) in human body. They are most often available in concentrated form as tablets, capsules, powder or liquid.

Objective: To investigate morphological parameters and the pharmaceutical availability of coated tablets – dietary supplements – that contain selected pharmacopeial titrated dry plant extracts.

Methods: Testing of the effective time of the tablet surface erosion was performed in model acceptor fluids using pharmacopeial methods in static (Erweka apparatus) and dynamic (unlimited diffusion method) conditions. Furthermore, morphological parameters of tablets (the original shape of an ellipse) as well as their hardness were determined.

Results: The effective erosion time was determined by conductometric method using carboxymethylcellulose sodium salt (NaCMC) contained in the tablet. The content of gum arabic and NaCMC in the tablet testifies that the granulate was produced using the “wet granulation” technique which resulted in high hardness of original, esthetic, elliptical tablets and in prolonged disintegration time (erosion).

Conclusions: The used excipients: gum arabic and NaCMC for the production of the tested tablets containing selected dry plant extracts result in their high hardness. The tested dietary supplements are characterized by esthetic design, original shape, and prolonged disintegration time which affects the pharmaceutical availability.

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Analytical Procedure for the Determination of Tulathromycin in Swine Plasma

References 1. Anon. U.S. Department of Health and Human Services, Food and Drug Administration (FDA), Center for Drug Evaluation and Research (CDER), Center for Veterinary Medicine: Guidance for Industry, Bioanalytical Method Validation, 2001. 2. Anon. European Medicines Agency (EMEA): Guideline on bioanalytical method validation, 2011. 3. Benchaoui H.A., Nowakowski M., Sherington J., Rowan T.G., Sunderland S.J.: Pharmacokinetics and lung tissue concentrations of tulathromycin in swine. J Vet Pharmacol

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